Hoth Therapeutics Receives USPTO Allowance for HT-KIT Patent
Written by Emily J. Thompson, Senior Investment Analyst
Updated: 5 days ago
0mins
Hoth Therapeutics announced that the U.S. Patent and Trademark Office, or USPTO, has issued a Notice of Allowance for Hoth's HT-KIT therapeutic. The allowed claims cover antisense oligomers of 25 to 50 linked nucleosides directed to splicing-relevant regions of the MS4A6A pre-mRNA, including intron 3, exon 4, and the intron 3/exon 4 junction, together with pharmaceutical compositions and methods for modulating MS4A6A mRNA splicing in cells or tissues. Hybridization of the disclosed oligomers is intended to reduce cell-surface expression of the high-affinity IgE receptor, a central driver of mast cell activation in allergic and inflammatory disease. Strategic importance includes: Allowance establishes composition-of-matter coverage for the Company's lead antisense oligomer, including modified, morpholino, and pharmaceutical composition embodiments, providing a defensible basis for the underlying chemistry of the platform; By reducing surface expression of FcRI via exon-skipping of MS4A6A pre-mRNA, the approach addresses a node upstream of histamine release and IgE-mediated degranulation, distinct from antihistamine, anti-IgE antibody, and small-molecule mast cell inhibitor approaches, Allowed method claims and related disclosures span asthma, atopic dermatitis, chronic rhinitis, allergic conjunctivitis, chronic sinusitis, anaphylaxis prevention, and mast cell-driven diseases including mastocytosis and mast cell tumors. Reinforces HT-KIT. The allowed claims strengthen the intellectual property foundation underlying HT-KIT, the Company's orphan drug-designated program for mast cell-driven disease; The application as filed also describes combination approaches with antisense oligomers targeting FcRIbeta pre-mRNA splicing, supporting future development of dual-target compositions.
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About HOTH
Rocket One Inc., formerly Hoth Therapeutics, Inc., is focused on developing and commercializing infrastructure for the orbital economy, including nanomagnetic AI chip technology designed for radiation-tolerant, energy-constrained environments such as low-Earth orbit, deep-space platforms, and defense systems. The Company holds exclusive rights to certain technologies, including a nanomagnetic matrix multiplier architecture intended as a hardware accelerator for machine learning and AI workloads, and related magnetic memory technology with potential applications in radiation-tolerant computing for defense and space systems. The Company is also positioned to pursue opportunities in nano-launch systems and nanosatellite deployment. The Company's biotechnology pipeline includes HT-001, HT-KIT, HT-ALZ, and GDNF-based metabolic program.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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- Technological Innovation: The allowed antisense oligomers aim to reduce cell-surface expression of the high-affinity IgE receptor, providing a novel therapeutic mechanism distinct from traditional antihistamines and small-molecule inhibitors, potentially offering better efficacy in allergic and inflammatory diseases.
- Broad Indication Coverage: The allowed method claims span various diseases, including asthma, atopic dermatitis, and allergic conjunctivitis, indicating the HT-KIT program's extensive potential in treating mast cell-driven diseases, which may open new market opportunities for the company.
- Strategic Restructuring Plan: Hoth is exploring placing its biotechnology pipeline and therapeutic development programs under a wholly owned subsidiary to better manage resources and protect shareholder value while continuing to pursue emerging opportunities in AI semiconductor infrastructure and advanced computing technologies.
See More
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- Space Stock Surge: Following NASA's announcement of near-monthly lunar missions starting in 2027, shares of Momentus (MNTS) jumped 26%, while Astrotech (ASTC) skyrocketed 459%, reflecting strong market interest and investment enthusiasm in space exploration.
- Funding and Growth: Momentus raised $25 million through a private placement, expecting to hold $76 million in cash, supporting its operations in in-space logistics and orbital transportation systems, highlighting its significance in NASA and defense contracts.
- Future Computing Opportunities: Astrotech is exploring future opportunities for lunar resources and infrastructure, including water extraction and rare material processing, indicating the company's long-term strategic focus on space computing and quantum systems.
See More
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See More
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- New Ticker Symbol: The company will begin trading under the new ticker symbol RKTO on Nasdaq starting May 28, replacing the current HOTH symbol, marking a significant shift towards its focus on the orbital economy.
- Exclusive Technology Rights: Hoth recently secured exclusive rights to nanomagnetic AI chip technology designed for ultra-low-power computing and high-radiation environments, which is expected to significantly enhance its applications in satellites and defense systems.
- Market Sentiment Shift: Following Hoth's pivot announcement, retail sentiment on Stocktwits flipped to 'extremely bullish', reflecting strong market anticipation for its new business strategy, although a major deal will be necessary to sustain the current stock momentum.
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- Exclusive Technology Rights: Rocket One has secured exclusive rights to next-generation nanomagnetic AI chip technology, which is particularly suited for operation in low Earth orbit and high-radiation environments, expected to enhance the company's competitiveness in the rapidly growing commercial space market.
- Market Opportunities: With the rise of small satellites and defense demand, Rocket One plans to leverage its technology platform to focus on AI chips, nano-launch systems, and defense applications, believing these markets are mutually reinforcing and will provide substantial growth potential.
- Management Outlook: CEO Robb Knie stated that the rebranding reflects the company's positioning in the orbital economy, emphasizing that the next decade will be defined by platforms capable of autonomous operation under power and radiation constraints, showcasing confidence to investors and partners.
See More
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- Scientific Validation: CEO Robb Knie stated that this allowance serves as a significant validation of the science underlying their mast cell platform, further strengthening the intellectual property foundation of the HT-KIT program, which may drive future clinical research and product development.
- IND Submission Plans: Hoth expects to finalize its IND submission for the HT-KIT program in 2026, followed by first-in-human studies, which will lay the groundwork for innovative treatments in mast cell-driven diseases.
- Subsidiary Structure Adjustment: The company is exploring placing its biotechnology pipeline and therapeutic development projects under a separate wholly-owned subsidiary to preserve the value of its biotechnology portfolio while enabling the parent company to pursue emerging opportunities in AI semiconductor infrastructure.
See More
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- Technological Innovation: The allowed antisense oligomers aim to reduce cell-surface expression of the high-affinity IgE receptor, providing a novel therapeutic mechanism distinct from traditional antihistamines and small-molecule inhibitors, potentially offering better efficacy in allergic and inflammatory diseases.
- Broad Indication Coverage: The allowed method claims span various diseases, including asthma, atopic dermatitis, and allergic conjunctivitis, indicating the HT-KIT program's extensive potential in treating mast cell-driven diseases, which may open new market opportunities for the company.
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See More
