GLP-1 Drug Market Set to Surge, Benefiting Lilly and Novo Nordisk
- Market Potential Surge: According to Circana's research, it is projected that by 2030, 35% of food and 37% of non-food units will come from GLP-1 households, indicating a significant increase in the drug's penetration into consumer daily life, potentially creating substantial market opportunities for related companies.
- New Drug Approval Outlook: Lilly's oral GLP-1 drug orforglipron is expected to receive FDA approval in 2026, providing a more convenient treatment option that could attract more patients to continue usage, thereby driving further growth for the company in the weight-loss drug market.
- Changing Consumer Habits: GLP-1 drug users are shifting their consumption patterns, with data showing a preference for healthier, protein-rich dining options, creating new market opportunities for the restaurant industry and prompting businesses to adjust menus to cater to this trend.
- Rising Demand for Healthy Foods: As GLP-1 drugs gain popularity, consumer demand for fresh foods is increasing, with NielsenIQ data indicating faster sales growth for fresh items located around the grocery store perimeter, posing a threat to packaged food companies lacking healthy options.
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- Trial Success: The LIBRETTO-432 trial demonstrated that Retevmo (selpercatinib) as adjuvant therapy significantly improved event-free survival (EFS) in early-stage RET fusion-positive non-small cell lung cancer (NSCLC) patients, indicating its potential value and likely enhancing market acceptance.
- Survival Trends Favorable: Although overall survival results were immature at the time of analysis, preliminary data showed a favorable trend for Retevmo, highlighting its importance in early treatment and potentially encouraging more patients to undergo genomic testing for optimized therapy.
- Patient Recruitment: The LIBRETTO-432 trial enrolled 151 patients randomized 1:1 to receive either Retevmo or placebo, ensuring the reliability and clinical applicability of the results, further validating the use of targeted therapies in lung cancer.
- Future Outlook: Eli Lilly plans to present detailed trial results at an upcoming medical congress and submit data to global health authorities, which is expected to accelerate the adoption of targeted therapies in early-stage NSCLC patients and promote the widespread use of genomic testing.

Overall Survival Results: The analysis indicates a trend in favor of Selpercatinib, suggesting improved overall survival rates for patients.
Immaturity of Analysis: The findings are considered immature due to the limited number of events observed during the analysis period.

Study Overview: The study focuses on Phase 3 of the Eli Lilly trial, which aims to evaluate the effectiveness of a new treatment.
Primary Endpoint: The primary endpoint of the study is to demonstrate improved event-free survival rates among participants.

Event-Free Survival Benefit: A recent study highlights the substantial event-free survival benefit of using LILLY's RETEVMO (selpercatinib) as an early-stage therapy for patients with positive lung cancer mutations.
Adjunct Therapy: RETEVMO is positioned as an adjunct therapy, enhancing treatment options for patients diagnosed with early-stage RET fusion-positive lung cancer.
- Trial Success: Eli Lilly announced that its TOGETHER-PsO open-label Phase 3b trial successfully met both primary and key secondary endpoints, demonstrating the efficacy of its weight loss therapy Zepbound combined with psoriasis therapy Taltz, marking a significant advancement for obese or overweight patients with plaque psoriasis.
- Significant Weight Loss: Over 36 weeks, 27% of patients receiving the combination therapy achieved at least a 10% weight loss and complete skin clearance, showcasing the potential of this combination therapy to improve patient quality of life, far exceeding the 5.8% achieved with Taltz alone.
- Efficacy Comparison: The key secondary endpoint revealed that patients on the combination regimen were 40% more likely to achieve PASI 100 compared to those receiving Taltz alone, further validating the advantages of using Zepbound with Taltz, which could enhance future market acceptance.
- Safety Profile: The trial reported mostly mild to moderate adverse events consistent with the known tolerability profiles of each drug, indicating the acceptability of this combination therapy in terms of safety, laying the groundwork for future regulatory discussions.
- Clinical Trial Results: In the TOGETHER-PsO study, the combination of Taltz and Zepbound achieved complete skin clearance (PASI 100) and ≥10% weight loss in 27.1% of patients at 36 weeks, significantly higher than the 5.8% in the Taltz monotherapy group (p<0.001), indicating the importance of combination therapy in improving patient quality of life.
- Significant Relative Advantage: Patients in the combination therapy group were 40% more likely to achieve PASI 100 compared to those on monotherapy, with rates of 40.6% versus 29.0% (p<0.05), demonstrating the positive impact of obesity treatment on psoriasis and providing new directions for future treatment strategies.
- High BMI Patient Population: The average BMI of study participants exceeded 39 kg/m², highlighting the high disease burden in this group and emphasizing the need for comprehensive treatment approaches for obesity and psoriasis, which could change clinical practice standards.
- Good Safety Profile: Adverse events in the combination therapy were generally mild to moderate, primarily including nausea, diarrhea, and injection site reactions, consistent with known safety profiles, indicating the feasibility and safety of this treatment regimen in clinical applications.







