Geron Reports Q4 Revenue of $48M
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Feb 25 2026
0mins
Should l Buy GERN?
Reports Q4 revenue $48M, consensus $50.43M. "Strategic actions we have taken in the second half of 2025 position Geron to drive RYTELO demand growth and invest to create value while lowering our total operating expenses year-over-year. In 2026, we are laser-focused on executing our commercial strategy," said Harout Semerjian, President and Chief Executive Officer of Geron. "The commercial opportunity for RYTELO in second-line lower-risk MDS is significant and supported by its FDA label, NCCN Guidelines and a growing body of scientific evidence. In the second half of 2026, we look forward to the IMpactMF interim analysis in relapsed/refractory myelofibrosis and the first data from real-world experience trials focused on the use of RYTELO in LR-MDS. Our priorities are to drive U.S. commercial growth, pursue pathways to bring RYTELO to patients outside the U.S., remain financially disciplined, and evaluate opportunistic innovation as we transform Geron into a leading, sustainable hematology company."
Trade with 70% Backtested Accuracy
Stop guessing "Should I Buy GERN?" and start using high-conviction signals backed by rigorous historical data.
Sign up today to access powerful investing tools and make smarter, data-driven decisions.
Analyst Views on GERN
Wall Street analysts forecast GERN stock price to rise
4 Analyst Rating
3 Buy
1 Hold
0 Sell
Strong Buy
Current: 1.390
Low
4.00
Averages
4.00
High
4.00
Current: 1.390
Low
4.00
Averages
4.00
High
4.00
About GERN
Geron Corporation is a commercial-stage biopharmaceutical company. The Company develops first-in-class telomerase inhibitor, RYTELO (imetelstat) for the treatment of adult patients with low- to intermediate-1 risk myelodysplastic syndromes (lower-risk MDS), with transfusion-dependent (TD) anemia requiring four or more red blood cell units over eight weeks who have not responded to or have lost response to or are ineligible for erythropoiesis-stimulating agents (ESAs). RYTELO is supported by the high unmet need in lower-risk MDS, including the observed benefit of RYTELO in difficult-to-treat subpopulations, such as patients with high transfusion burden and ring sideroblast negative (RS-) patients. It is also engaged in conducting a pivotal Phase III clinical trial of imetelstat in JAK-inhibitor relapsed/refractory myelofibrosis (R/R MF), as well as studies in other myeloid hematologic malignancies.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
Geron Reports Q1 Earnings Beat Expectations
- Earnings Highlights: Geron reported a Q1 GAAP EPS of -$0.01, beating expectations by $0.01, with revenue of $51.84 million, reflecting a 30.9% year-over-year increase and surpassing estimates by $1.25 million, indicating a positive trend in financial performance.
- Demand Growth: RYTELO demand grew by 6% in Q1 2026 compared to Q4 2025, suggesting an increase in product acceptance in the market, which may lay the groundwork for future sales growth.
- Customer Base Expansion: The number of ordering accounts increased by approximately 12% in Q1 2026 to about 1,450, reflecting success in customer acquisition and market penetration strategies.
- Future Outlook: The company expects RYTELO net product revenue for fiscal year 2026 to be in the range of $220 million to $240 million, while total operating expenses are anticipated to be between $230 million and $240 million, demonstrating cautious optimism regarding future financial health.
See More
Geron Corporation Q1 Earnings Announcement Scheduled
- Earnings Release Date: Geron Corporation is set to announce its Q1 earnings on May 6 before market open, with a consensus EPS estimate of -$0.02, indicating ongoing challenges in profitability.
- Revenue Growth Expectations: The anticipated revenue for Q1 is $50.59 million, reflecting a 27.8% year-over-year increase, which, despite minimal overall sales growth, may indicate a gradual market acceptance of its products.
- Earnings Forecast Revisions: Over the past three months, EPS estimates have seen one upward revision with no downward adjustments, suggesting cautious optimism among analysts regarding the company's future performance, although revenue estimates have faced four downward revisions, highlighting concerns about revenue growth.
- Market Reaction: Geron has previously missed earnings expectations, resulting in a decline in stock price, and analysts' views on its future performance have become more conservative, reflecting investor skepticism about the company's outlook.
See More
GERN Reports 2025 Financial Highlights and Future Guidance
- 2025 Revenue Performance: GERN reported a net revenue of $48 million in Q4 2025, contributing to a total of $184 million for the year, marking a successful first full commercial year for RYTELO, although operating expenses reached $255 million, highlighting profitability challenges.
- Future Revenue Guidance: The company projects RYTELO net revenue for 2026 to be between $220 million and $240 million, reflecting optimistic expectations for market demand, while operating expenses are expected to decrease by $20 million, indicating efforts in cost control.
- Cash Flow and Financial Flexibility: As of December 31, 2025, GERN holds approximately $400 million in cash and equivalents, enhancing the company's financial flexibility to make strategic investments in a competitive market.
- Market Expansion Strategy: GERN is focusing on approximately 8,000 second-line lower-risk MDS patients and plans to enhance market share by refining messaging and targeting high-volume accounts, despite uncertainties surrounding the European market strategy.
See More
Geron Corporation Misses Q4 Earnings Forecasts, Shares Drop 15%
- Earnings Miss: Geron Corporation reported a Q4 2025 net loss of $0.05 per share on $48 million in revenue, falling short of analysts' expectations by over $2.4 million, indicating stagnation in revenue growth that could undermine investor confidence.
- Widening Losses: The company's total costs and operating expenses rose approximately 2% year-over-year to $254.7 million, while the net loss for Q4 widened by about 23% to $31.1 million, primarily due to a $17 million restructuring expense, reflecting challenges in cost management.
- Significant Revenue Growth: Despite the losses, Geron's full-year revenue more than doubled to $183.9 million, driven by FDA approval of Rytelo for a rare blood cancer, showcasing the market potential of new products and laying a foundation for future growth.
- Cautious Outlook: The company projects full-year net product revenue for Rytelo to be between $220 million and $240 million, with operating expenses expected to range from $230 million to $240 million, indicating a need to manage costs and competitive pressures despite growth expectations.
See More
Geron (GERN) Q4 2025 Earnings Call Transcript
See More
Geron Corp. Reports Q4 2025 Results with Focus on RYTELO Sales Growth
- Sales Growth: Geron Corp. reported total revenue of $48 million for Q4 2025, falling short of analysts' expectations of $50.88 million, indicating ongoing challenges in promoting its blood cancer therapy RYTELO.
- Product Sales Performance: RYTELO achieved net product sales of $48 million in Q4 and $183.6 million for the full year, with a 9% increase in quarterly sales compared to the previous quarter, yet overall performance did not meet market expectations.
- Customer Base Expansion: The number of ordering accounts for RYTELO increased by 150 to approximately 1,300, suggesting that the company is gradually enhancing its market penetration in the lower-risk myelodysplastic syndromes (LR-MDS) segment.
- Market Reaction: Following the earnings report, Geron's stock traded over 10% lower in Wednesday's premarket, reflecting investor disappointment over the company's performance not meeting expectations.
See More
Geron Reports Q1 Earnings Beat Expectations
- Earnings Highlights: Geron reported a Q1 GAAP EPS of -$0.01, beating expectations by $0.01, with revenue of $51.84 million, reflecting a 30.9% year-over-year increase and surpassing estimates by $1.25 million, indicating a positive trend in financial performance.
- Demand Growth: RYTELO demand grew by 6% in Q1 2026 compared to Q4 2025, suggesting an increase in product acceptance in the market, which may lay the groundwork for future sales growth.
- Customer Base Expansion: The number of ordering accounts increased by approximately 12% in Q1 2026 to about 1,450, reflecting success in customer acquisition and market penetration strategies.
- Future Outlook: The company expects RYTELO net product revenue for fiscal year 2026 to be in the range of $220 million to $240 million, while total operating expenses are anticipated to be between $230 million and $240 million, demonstrating cautious optimism regarding future financial health.
See More
Geron Corporation Q1 Earnings Announcement Scheduled
- Earnings Release Date: Geron Corporation is set to announce its Q1 earnings on May 6 before market open, with a consensus EPS estimate of -$0.02, indicating ongoing challenges in profitability.
- Revenue Growth Expectations: The anticipated revenue for Q1 is $50.59 million, reflecting a 27.8% year-over-year increase, which, despite minimal overall sales growth, may indicate a gradual market acceptance of its products.
- Earnings Forecast Revisions: Over the past three months, EPS estimates have seen one upward revision with no downward adjustments, suggesting cautious optimism among analysts regarding the company's future performance, although revenue estimates have faced four downward revisions, highlighting concerns about revenue growth.
- Market Reaction: Geron has previously missed earnings expectations, resulting in a decline in stock price, and analysts' views on its future performance have become more conservative, reflecting investor skepticism about the company's outlook.
See More
GERN Reports 2025 Financial Highlights and Future Guidance
- 2025 Revenue Performance: GERN reported a net revenue of $48 million in Q4 2025, contributing to a total of $184 million for the year, marking a successful first full commercial year for RYTELO, although operating expenses reached $255 million, highlighting profitability challenges.
- Future Revenue Guidance: The company projects RYTELO net revenue for 2026 to be between $220 million and $240 million, reflecting optimistic expectations for market demand, while operating expenses are expected to decrease by $20 million, indicating efforts in cost control.
- Cash Flow and Financial Flexibility: As of December 31, 2025, GERN holds approximately $400 million in cash and equivalents, enhancing the company's financial flexibility to make strategic investments in a competitive market.
- Market Expansion Strategy: GERN is focusing on approximately 8,000 second-line lower-risk MDS patients and plans to enhance market share by refining messaging and targeting high-volume accounts, despite uncertainties surrounding the European market strategy.
See More
Geron Corporation Misses Q4 Earnings Forecasts, Shares Drop 15%
- Earnings Miss: Geron Corporation reported a Q4 2025 net loss of $0.05 per share on $48 million in revenue, falling short of analysts' expectations by over $2.4 million, indicating stagnation in revenue growth that could undermine investor confidence.
- Widening Losses: The company's total costs and operating expenses rose approximately 2% year-over-year to $254.7 million, while the net loss for Q4 widened by about 23% to $31.1 million, primarily due to a $17 million restructuring expense, reflecting challenges in cost management.
- Significant Revenue Growth: Despite the losses, Geron's full-year revenue more than doubled to $183.9 million, driven by FDA approval of Rytelo for a rare blood cancer, showcasing the market potential of new products and laying a foundation for future growth.
- Cautious Outlook: The company projects full-year net product revenue for Rytelo to be between $220 million and $240 million, with operating expenses expected to range from $230 million to $240 million, indicating a need to manage costs and competitive pressures despite growth expectations.
See More
Geron (GERN) Q4 2025 Earnings Call Transcript
See More
Geron Corp. Reports Q4 2025 Results with Focus on RYTELO Sales Growth
- Sales Growth: Geron Corp. reported total revenue of $48 million for Q4 2025, falling short of analysts' expectations of $50.88 million, indicating ongoing challenges in promoting its blood cancer therapy RYTELO.
- Product Sales Performance: RYTELO achieved net product sales of $48 million in Q4 and $183.6 million for the full year, with a 9% increase in quarterly sales compared to the previous quarter, yet overall performance did not meet market expectations.
- Customer Base Expansion: The number of ordering accounts for RYTELO increased by 150 to approximately 1,300, suggesting that the company is gradually enhancing its market penetration in the lower-risk myelodysplastic syndromes (LR-MDS) segment.
- Market Reaction: Following the earnings report, Geron's stock traded over 10% lower in Wednesday's premarket, reflecting investor disappointment over the company's performance not meeting expectations.
See More
