Fulcrum Therapeutics Shares Surge Following Encouraging Sickle Cell Study Results
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Dec 08 2025
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Source: Benzinga
Stock Surge: Fulcrum Therapeutics Inc's stock is rising significantly following positive initial results from the 20 mg dose cohort of the Phase 1b PIONEER trial for pociredir in sickle cell disease.
Positive Trial Results: The trial showed a 9.9% increase in mean absolute fetal hemoglobin (HbF) at six weeks, with 58% of patients achieving HbF levels ≥20%, which is linked to a reduction in vaso-occlusive crises.
Analyst Upgrades: Several analysts have raised their price forecasts for Fulcrum Therapeutics, with HC Wainwright increasing it from $18 to $25, and Piper Sandler from $16 to $23, reflecting confidence in the company's prospects.
Current Stock Performance: As of the latest publication, Fulcrum Therapeutics' stock is up 9.66%, trading at $14.21.
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Analyst Views on FULC
Wall Street analysts forecast FULC stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for FULC is 16.80 USD with a low forecast of 7.00 USD and a high forecast of 25.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
10 Analyst Rating
8 Buy
1 Hold
1 Sell
Moderate Buy
Current: 10.480
Low
7.00
Averages
16.80
High
25.00
Current: 10.480
Low
7.00
Averages
16.80
High
25.00
About FULC
Fulcrum Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on developing small molecules to improve the lives of patients with genetically defined rare diseases in areas of high unmet medical need. The Company's lead clinical program is pociredir, a small molecule designed to increase expression of fetal hemoglobin for the treatment of sickle cell disease (SCD). It uses technology to identify drug targets that can modulate gene expression to treat the known root cause of gene mis-expression. In addition to its product candidates, the Company has developed a discovery approach that it employs to systematically identify and validate cellular drug targets that can potentially modulate gene expression to treat known root causes of genetically defined rare diseases. The Company continues to advance its program for the potential treatment of inherited aplastic anemias, such as Diamond-Blackfan anemia (DBA), Shwachman-Diamond syndrome, and Fanconi anemia.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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Fulcrum Grants 30,400 Stock Options to New Employees at $10.84 Exercise Price
- Employee Incentive Program: Fulcrum Therapeutics granted 30,400 stock options to three new employees under its 2022 Inducement Stock Incentive Plan at an exercise price of $10.84 per share, aimed at attracting and retaining key talent, thereby enhancing the company's competitive edge in the rare disease sector.
- Option Structure: The options have a ten-year term and vest over four years, with 25% vesting on the first anniversary and the remainder vesting quarterly, ensuring continued employee contribution during their tenure, which enhances team stability and execution capability.
- Market Reaction: Fulcrum's stock closed at $10.84 on the grant date, reflecting the company's confidence in future growth while enhancing employee ownership and morale through incentive measures, which can boost overall productivity.
- Strategic Implications: This option grant is not only an incentive for new hires but also a critical move by Fulcrum to leverage talent attraction and retention strategies to drive innovation and business expansion in the rapidly evolving biopharmaceutical industry.
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