Eupraxia Pharmaceuticals Reports Positive 12-Week and 36-Week Data for EP-104GI in EoE Treatment
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Jan 08 2026
0mins
Should l Buy EPRX?
Source: NASDAQ.COM
- Clinical Trial Progress: Eupraxia Pharmaceuticals announced positive 12-week and 36-week tissue health data from the Phase 1b/2a RESOLVE trial for EP-104GI, indicating the drug's potential in treating eosinophilic esophagitis (EoE), particularly with the highest dose group showing the greatest improvement from baseline.
- Sustained Efficacy: Patients in the 4mg/site dose group maintained their 12-week improvements at 36 weeks, suggesting that the drug not only effectively manages symptoms but also addresses the underlying pathology of EoE at the tissue level.
- Future Data Release: The company expects to release top-line data from the Phase 2b part of the RESOLVE trial in Q3 2026, which will provide critical insights for the further development of EP-104GI and could influence future market positioning and investor confidence.
- Market Reaction: EPRX shares traded at $7.17 in pre-market hours on Nasdaq, down 0.55%, reflecting a cautious market response to the new data, which may impact the company's short-term stock performance.
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Analyst Views on EPRX
Wall Street analysts forecast EPRX stock price to rise
4 Analyst Rating
4 Buy
0 Hold
0 Sell
Strong Buy
Current: 8.050
Low
11.02
Averages
13.02
High
16.03
Current: 8.050
Low
11.02
Averages
13.02
High
16.03
About EPRX
Eupraxia Pharmaceuticals Inc. is a clinical-stage biotechnology company. The Company is focused on the development of locally delivered, extended-release products that have the potential to address therapeutic areas with high unmet medical need. DiffuSphere, a proprietary, polymer-based micro-sphere technology, is designed to facilitate targeted drug delivery of both existing and novel drugs. The Company’s EP-104GI is in a Phase Ib/IIa trial, the RESOLVE trial, for the treatment of eosinophilic esophagitis (EoE). EP-104GI is administered as an injection into the esophageal wall, providing local delivery of drug. The Company also completed a Phase IIb clinical trial (SPRINGBOARD) of EP-104IAR for the treatment of pain due to knee osteoarthritis. In addition, the Company is developing a pipeline of later and earlier-stage long-acting formulations. Its potential pipeline indications include candidates for other inflammatory joint indications and oncology.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
Eupraxia Completes Public Offering of 7.6 Million Shares
- Successful Financing: Eupraxia Pharmaceuticals has successfully closed a public offering of 7.6 million common shares, raising approximately $63.2 million, which will significantly enhance its research capabilities for EP-104GI targeting eosinophilic esophagitis and facilitate the achievement of multiple development milestones.
- Clear Use of Proceeds: The company intends to allocate the funds primarily towards clinical trials for EP-104GI, including ongoing Phase 2 trials and preparations for a Phase 3 trial, thereby accelerating the product's market readiness to meet demand.
- Market Expansion Plans: Eupraxia will also use a portion of the proceeds to expedite clinical studies in additional gastrointestinal indications, such as esophageal strictures and fibrostenotic Crohn's disease, further broadening its product pipeline and enhancing market competitiveness.
- Strategic Investment: This fundraising not only supports the advancement of existing projects but also funds the development of new pipeline candidates and strengthens corporate infrastructure, ensuring sustainable growth and demonstrating the company's long-term commitment to the biotechnology sector.
See More
Eupraxia Pharmaceuticals Prices Public Offering
- Offering Pricing: Eupraxia Pharmaceuticals has priced its public offering at $7.00 per share for 6.43 million common shares and 1.43 million pre-funded warrants, aiming for gross proceeds of approximately $55 million before expenses, indicating the company's ability to raise capital in the market.
- Market Reaction: Following the announcement of the public offering, Eupraxia's shares fell by 9.3% to $7.40 in premarket trading, reflecting a negative market response and investor concerns regarding the company's future prospects.
- Underwriter Team: Cantor and LifeSci Capital are acting as joint book-running managers for the offering, with Bloom Burton and Craig-Hallum serving as co-managers, demonstrating the support from multiple parties in the financing process.
- Use of Proceeds: The funds raised from this offering are intended to support Eupraxia's research and development as well as operational needs, aiming to advance its product pipeline, although the negative market reaction highlights the challenges the company faces in executing its long-term growth strategy.
See More
Eupraxia Pharmaceuticals Prices $55 Million Public Offering
- Offering Size: Eupraxia Pharmaceuticals has priced a public offering at $55 million, expected to close around February 20, 2026, with proceeds aimed at advancing key programs and expanding its proprietary Diffusphere technology.
- Program Development: The company plans to utilize the funds to advance its lead programs, including EP-104GI, currently in Phase 1b/2 RESOLVE trial, with topline data from the Phase 2b expected in Q3 2026.
- Financial Position: As of September 30, 2025, Eupraxia reported $89 million in cash, and with the new offering, it projects a funding runway into the first half of 2028, supporting multiple late-stage programs and pipeline expansion.
- Stock Performance: EPRX has traded between $2.68 and $9.32 over the past year, closing at $8.16, down 0.85%, and showing a pre-market decline of over 9% to $7.40, indicating cautious market sentiment regarding the offering.
See More
Eupraxia Pharmaceuticals Prices Public Offering at $7.00 per Share
- Offering Size: Eupraxia Pharmaceuticals announced the pricing of 6,428,574 common shares at $7.00 each, expecting gross proceeds of approximately $55 million, indicating strong market demand and investor confidence in the company.
- Pre-Funded Warrant Structure: The company is also offering pre-funded warrants to purchase 1,428,571 common shares at $6.99999, enhancing investor participation and providing flexible financing options for the company.
- Use of Proceeds: The funds will primarily support the advancement of EP-104GI for Eosinophilic Esophagitis, including ongoing preclinical studies and Phase 2 trials, demonstrating the company's commitment to drug development.
- Market Expansion Strategy: Eupraxia plans to use part of the proceeds to accelerate clinical studies in multiple gastrointestinal indications, showcasing its innovative potential and strategic intent for market expansion in the biotechnology sector.
See More
Eupraxia Pharmaceuticals Proposes Public Offering of Common Shares
- Public Offering Announcement: Eupraxia Pharmaceuticals filed a preliminary prospectus supplement on Wednesday for a proposed public offering of common shares or pre-funded warrants, with underwriters expected to receive a 30-day option to purchase up to 15% of the offered securities.
- Clear Use of Proceeds: The proceeds from this offering are primarily intended to advance EP-104GI for Eosinophilic Esophagitis, including ongoing preclinical studies and Phase 2 trials, as well as preparations for a Phase 3 trial, indicating the company's commitment to product development.
- Market Reaction: Following the announcement, EPRX's stock price fell by 1.96% in after-hours trading to $8.0, reflecting a cautious market sentiment regarding the offering, which may impact investor confidence.
- Future Growth Potential: Although the size and pricing of the offering have yet to be determined, Eupraxia's strategic investment is expected to support its long-term growth in the biopharmaceutical sector, particularly in the market for Eosinophilic Esophagitis treatments.
See More
Eupraxia Pharmaceuticals Reports Significant Tissue Health Improvements in EoE Trial
- Significant Efficacy: In the RESOLVE trial, patients receiving the highest dose (8 mg/site) showed nearly complete normalization of esophageal tissue at 12 weeks, indicating the drug's potential in treating eosinophilic esophagitis (EoE).
- Improved Remission Rates: At 12 weeks (n=19), 58% of patients achieved clinical remission, while 79% maintained remission at 24 weeks (n=14), demonstrating the sustained effectiveness of the treatment.
- Good Safety Profile: To date, over 200 patient-months of follow-up have been reported in 31 patients, with no serious adverse events or cases of oral candidiasis, indicating that EP-104GI is well tolerated at all dose levels.
- Long-term Tracking Data: At 52 weeks (n=6), 67% of patients maintained clinical remission, further validating the drug's long-term efficacy and safety, which may lay the groundwork for future market promotion.
See More
Eupraxia Completes Public Offering of 7.6 Million Shares
- Successful Financing: Eupraxia Pharmaceuticals has successfully closed a public offering of 7.6 million common shares, raising approximately $63.2 million, which will significantly enhance its research capabilities for EP-104GI targeting eosinophilic esophagitis and facilitate the achievement of multiple development milestones.
- Clear Use of Proceeds: The company intends to allocate the funds primarily towards clinical trials for EP-104GI, including ongoing Phase 2 trials and preparations for a Phase 3 trial, thereby accelerating the product's market readiness to meet demand.
- Market Expansion Plans: Eupraxia will also use a portion of the proceeds to expedite clinical studies in additional gastrointestinal indications, such as esophageal strictures and fibrostenotic Crohn's disease, further broadening its product pipeline and enhancing market competitiveness.
- Strategic Investment: This fundraising not only supports the advancement of existing projects but also funds the development of new pipeline candidates and strengthens corporate infrastructure, ensuring sustainable growth and demonstrating the company's long-term commitment to the biotechnology sector.
See More
Eupraxia Pharmaceuticals Prices Public Offering
- Offering Pricing: Eupraxia Pharmaceuticals has priced its public offering at $7.00 per share for 6.43 million common shares and 1.43 million pre-funded warrants, aiming for gross proceeds of approximately $55 million before expenses, indicating the company's ability to raise capital in the market.
- Market Reaction: Following the announcement of the public offering, Eupraxia's shares fell by 9.3% to $7.40 in premarket trading, reflecting a negative market response and investor concerns regarding the company's future prospects.
- Underwriter Team: Cantor and LifeSci Capital are acting as joint book-running managers for the offering, with Bloom Burton and Craig-Hallum serving as co-managers, demonstrating the support from multiple parties in the financing process.
- Use of Proceeds: The funds raised from this offering are intended to support Eupraxia's research and development as well as operational needs, aiming to advance its product pipeline, although the negative market reaction highlights the challenges the company faces in executing its long-term growth strategy.
See More
Eupraxia Pharmaceuticals Prices $55 Million Public Offering
- Offering Size: Eupraxia Pharmaceuticals has priced a public offering at $55 million, expected to close around February 20, 2026, with proceeds aimed at advancing key programs and expanding its proprietary Diffusphere technology.
- Program Development: The company plans to utilize the funds to advance its lead programs, including EP-104GI, currently in Phase 1b/2 RESOLVE trial, with topline data from the Phase 2b expected in Q3 2026.
- Financial Position: As of September 30, 2025, Eupraxia reported $89 million in cash, and with the new offering, it projects a funding runway into the first half of 2028, supporting multiple late-stage programs and pipeline expansion.
- Stock Performance: EPRX has traded between $2.68 and $9.32 over the past year, closing at $8.16, down 0.85%, and showing a pre-market decline of over 9% to $7.40, indicating cautious market sentiment regarding the offering.
See More
Eupraxia Pharmaceuticals Prices Public Offering at $7.00 per Share
- Offering Size: Eupraxia Pharmaceuticals announced the pricing of 6,428,574 common shares at $7.00 each, expecting gross proceeds of approximately $55 million, indicating strong market demand and investor confidence in the company.
- Pre-Funded Warrant Structure: The company is also offering pre-funded warrants to purchase 1,428,571 common shares at $6.99999, enhancing investor participation and providing flexible financing options for the company.
- Use of Proceeds: The funds will primarily support the advancement of EP-104GI for Eosinophilic Esophagitis, including ongoing preclinical studies and Phase 2 trials, demonstrating the company's commitment to drug development.
- Market Expansion Strategy: Eupraxia plans to use part of the proceeds to accelerate clinical studies in multiple gastrointestinal indications, showcasing its innovative potential and strategic intent for market expansion in the biotechnology sector.
See More
Eupraxia Pharmaceuticals Proposes Public Offering of Common Shares
- Public Offering Announcement: Eupraxia Pharmaceuticals filed a preliminary prospectus supplement on Wednesday for a proposed public offering of common shares or pre-funded warrants, with underwriters expected to receive a 30-day option to purchase up to 15% of the offered securities.
- Clear Use of Proceeds: The proceeds from this offering are primarily intended to advance EP-104GI for Eosinophilic Esophagitis, including ongoing preclinical studies and Phase 2 trials, as well as preparations for a Phase 3 trial, indicating the company's commitment to product development.
- Market Reaction: Following the announcement, EPRX's stock price fell by 1.96% in after-hours trading to $8.0, reflecting a cautious market sentiment regarding the offering, which may impact investor confidence.
- Future Growth Potential: Although the size and pricing of the offering have yet to be determined, Eupraxia's strategic investment is expected to support its long-term growth in the biopharmaceutical sector, particularly in the market for Eosinophilic Esophagitis treatments.
See More
Eupraxia Pharmaceuticals Reports Significant Tissue Health Improvements in EoE Trial
- Significant Efficacy: In the RESOLVE trial, patients receiving the highest dose (8 mg/site) showed nearly complete normalization of esophageal tissue at 12 weeks, indicating the drug's potential in treating eosinophilic esophagitis (EoE).
- Improved Remission Rates: At 12 weeks (n=19), 58% of patients achieved clinical remission, while 79% maintained remission at 24 weeks (n=14), demonstrating the sustained effectiveness of the treatment.
- Good Safety Profile: To date, over 200 patient-months of follow-up have been reported in 31 patients, with no serious adverse events or cases of oral candidiasis, indicating that EP-104GI is well tolerated at all dose levels.
- Long-term Tracking Data: At 52 weeks (n=6), 67% of patients maintained clinical remission, further validating the drug's long-term efficacy and safety, which may lay the groundwork for future market promotion.
See More
