DiaMedica Cash and Short-Term Investments Rise to $59.9 Million
Cash and short-term investments were $59.9 million as of December 31, 2025, compared to $44.1 million as of December 31, 2024. The increase in cash and short-term investments is due to net proceeds received from the sale of common shares in the Company's July 2025 private placement and under its at-the-market offering program. Based on its current plans, the Company anticipates its current cash and short-term investments will be sufficient to fund its planned clinical studies and support corporate operations through the second half of 2027. "We continue to make meaningful progress across our clinical programs, highlighted by further advancement of the DM199 preeclampsia (PE) program. In the IST, enrollment continues in the expansion cohort for Part 1a, and we anticipate initiating Parts 2 and 3, which will evaluate participants with early-onset preeclampsia and fetal growth restriction. We are also preparing to initiate a DiaMedica-sponsored Phase 2 study in early-onset preeclampsia later this year. There remains a critical need for differentiated, well-tolerated therapies that can deliver clinically meaningful benefits, prolong pregnancy, and improve outcomes for both the mother and baby," said Rick Pauls, President and Chief Executive Officer of DiaMedica Therapeutics. "We are encouraged by the momentum in our ReMEDy2 acute ischemic stroke trial, which is approaching 70% of the required enrollment for the planned interim analysis, and we remain on track to complete the interim analysis in the second half of 2026. This, combined with a strong cash position expected to fund operations through the second half of 2027, supports our continued focus on advancing DM199 through key clinical and regulatory milestones in 2026."
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- Conference Announcement: DiaMedica Therapeutics Inc. will present at the Jefferies Global Healthcare Conference in New York from June 2-4, 2026, with a corporate presentation scheduled for June 4 at 3:45 PM ET, highlighting its clinical-stage biopharmaceutical advancements.
- Product Focus: The company is dedicated to developing innovative treatments for preeclampsia, fetal growth restriction, and acute ischemic stroke, aiming to enhance the quality of life for patients suffering from serious ischemic diseases, underscoring its strategic significance in the healthcare sector.
- Lead Candidate: DiaMedica's lead candidate DM199 is the first pharmaceutically active recombinant (synthetic) form of the KLK1 protein, which has been established as an effective therapy in Asia for treating acute ischemic stroke and other vascular diseases, indicating its potential in the global market.
- Investor Relations: The company encourages interested investors to arrange one-on-one meetings with management to discuss its R&D progress and market strategies, reflecting its commitment to investor communication.
- Enrollment Milestone: DiaMedica Therapeutics announced that its ReMEDy2 trial for DM199 has reached 75% of the 200-patient enrollment threshold, indicating that 150 patients have been enrolled, reflecting the dedication of clinical sites and the urgent need for new treatments for acute ischemic stroke patients.
- Interim Analysis Plan: An independent Data Safety Monitoring Board (DSMB) will conduct an interim analysis to assess whether a sample size re-estimation is recommended, with the final sample size expected to range between 300 and 728 patients, ensuring the trial's statistical power and integrity.
- Clinical Trial Design: The ReMEDy2 trial is an adaptive, randomized, double-blind, placebo-controlled study, with the primary efficacy endpoint being the modified Rankin Score (mRS) at Day 90, which will directly impact the clinical application prospects of DM199 in treating acute ischemic stroke.
- Future Outlook: The interim analysis is anticipated to be completed before the end of 2026, marking a critical inflection point that will provide essential data to guide the development path of DM199, potentially influencing the company's future R&D direction and funding allocation.
- Clinical Trial Progress: DiaMedica's DM199 is currently enrolling in the Phase 2 IST clinical trial for preeclampsia, with data expected in Q2 2026, which may provide critical dosing information for a potential multinational Phase 3 program.
- Acute Ischemic Stroke Study: The ReMEDy2 trial has surpassed 70% of the required enrollment, with an interim analysis planned for Q4 2026, which will determine the final number of participants needed to complete the study, thus impacting the overall timeline of the clinical trial.
- Financial Status Update: As of March 31, 2026, DiaMedica reported cash and short-term investments of $51.3 million, which is anticipated to support corporate operations through 2027, despite a decrease from $59.9 million at the end of 2025, indicating a stable financial position for ongoing clinical research.
- Increased R&D Spending: R&D expenses for Q1 2026 reached $8.0 million, significantly up from $5.7 million in Q1 2025, primarily driven by the ongoing ReMEDy2 trial and its global expansion, reflecting the company's strategic focus on research and development investment.
- Oversold Signal: DiaMedica Therapeutics Inc (Ticker: DMAC) hit an RSI of 28.4 during Wednesday's trading, indicating an oversold condition that suggests the recent heavy selling may be exhausting, prompting bullish investors to seek buying opportunities.
- Price Fluctuation: DMAC shares traded as low as $6.065, with the current price at $6.19, showing a significant recovery from the 52-week low of $3.26, yet still far below the 52-week high of $10.4195, reflecting market uncertainty.
- Market Comparison: Compared to the S&P 500 ETF (SPY) with an RSI of 57.1, DMAC's low RSI may attract bullish investors who see potential for a price rebound, potentially stimulating buying interest.
- Investor Sentiment: While DMAC is currently in an oversold state, investors should cautiously assess market sentiment and fundamentals to avoid making impulsive decisions in an uncertain market environment.
- Clinical Trial Progress: DiaMedica's DM199 Phase II trial for preeclampsia in South Africa shows statistically significant reductions in blood pressure and uterine artery pulsatility index, with no placental transfer, indicating its potential application in preeclampsia and related conditions.
- Strong Financial Position: As of December 31, 2025, the company reported $59.9 million in cash and short-term investments, which is expected to fund clinical studies and corporate operations through the end of 2027, reflecting robust financial health.
- Trial Expansion Plans: The company anticipates completing the preeclampsia expansion cohort with 12 additional patients in the first half of 2026, while also planning to initiate two new cohorts in Q2, demonstrating ongoing commitment to clinical research.
- Stroke Program Progress: DiaMedica has achieved nearly 70% enrollment of the required 200 participants for its stroke program, with guidance to complete the interim analysis by the second half of 2026, showcasing the company's execution capability and confidence in this area.
- Disappointing Earnings: DiaMedica Therapeutics reported a FY GAAP EPS of -$0.70, missing expectations by $0.02, indicating ongoing challenges in profitability that could negatively impact investor confidence.
- Cash Position Improvement: As of December 31, 2025, the company had $59.9 million in cash and short-term investments, up from $44.1 million a year earlier, suggesting improved cash management, though ongoing losses remain a concern.
- Increased Operating Cash Usage: The net cash used in operating activities for the year ended December 31, 2025, was $29.1 million, an increase from $22.1 million in 2024, reflecting heightened pressure on operational expenditures that may affect future liquidity.
- Historical Financial Insights: Historical financial data for DiaMedica Therapeutics indicates that while cash reserves have increased, persistent losses and high operational costs could limit future growth potential.








