Bolt Biotherapeutics to Cut Workforce by Half and Provide Update on BDC-4182 Study
Clinical Trial Update: Bolt Biotherapeutics reported positive immune responses in the Phase 1 study of BDC-4182, a candidate targeting claudin 18.2, and is modifying the trial protocol for step-up dosing, expecting initial data by Q3 2026.
Workforce Reduction and Financial Strategy: To conserve capital and enhance shareholder value, Bolt is reducing its workforce by approximately 50%, which will extend its financial runway into 2027.
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Bolt Announces Q3 2025 Financial Results and Updates on Oncology Pipeline Advancements
Company Overview: Bolt Biotherapeutics, Inc. reported its Q3 2025 financial results, highlighting its focus on developing immunotherapies for cancer through its proprietary Boltbody ISAC platform, which includes two clinical-stage candidates, BDC-3042 and BDC-4182.
Clinical Trials Update: BDC-3042, targeting tumor-associated macrophages, has shown early signs of immune activation in a Phase 1 study, while BDC-4182 is being evaluated for gastric and gastroesophageal cancers, with initial data expected in Q3 2026.
Financial Performance: The company reported a narrowed net loss of $7.1 million for Q3 2025, a significant improvement from the previous year, attributed to reduced R&D and G&A costs following a corporate restructuring.
Stock Performance: Bolt's stock has fluctuated between $4.42 and $13 over the past year, closing at $4.69 recently, with a slight increase in overnight trading.
HC Wainwright & Co. Initiates Coverage on Bolt Biotherapeutics with a Buy Rating and Sets Price Target at $7
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Bolt Biotherapeutics Presents Results from the Phase 1 Dose-Escalation Clinical Study of BDC-3042 at AACR Annual Meeting 2025
Clinical Study Results: BDC-3042, a novel immunotherapy developed by Bolt Biotherapeutics, demonstrated a favorable safety profile and biological activity in a Phase 1 clinical trial, with no serious adverse events reported and signs of anti-tumor activity in patients with various cancers.
Future Development Plans: The company is seeking partnerships to accelerate the development of BDC-3042, which targets dectin-2 on tumor-associated macrophages, and aims to explore its potential in combination with other therapies for improved patient outcomes.
HC Wainwright & Co. Reiterates Neutral on Bolt Biotherapeuticsto Neutral
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Community of Traders: Over 10,000 serious traders are part of the Benzinga Pro community, gaining access to exclusive stories and insights from Benzinga reporters.
Bolt Biotherapeutics Reports Fourth Quarter and Full-Year 2024 Financial Results and Provides Business Update
Clinical Trials Update: Bolt Biotherapeutics is set to begin a clinical trial for BDC-4182, targeting gastric cancer, in the second quarter of 2025, while the Phase 1 trial for BDC-3042 has been fully enrolled with no dose-limiting toxicities reported.
Financial Overview: As of December 31, 2024, Bolt Biotherapeutics has a cash balance of $70.2 million, expected to fund operations and key milestones through mid-2026, despite reporting a net loss of $63.1 million for the year.
Bolt Biotherapeutics provides update on co-development collaboration with Toray
Collaboration Announcement: Bolt Biotherapeutics is collaborating with Toray Industries to develop a Boltbody Immune-Stimulating Antibody Conjugate targeting Caprin-1, a cancer target discovered by Toray, applicable to various solid tumors.
Joint Development Agreement: Under their agreement, Toray provides proprietary antibodies like TRK-950, while Bolt contributes linker-payloads from its technology platform, aiming for co-development and commercialization of the resulting product candidate.
Bolt Announces Q3 2025 Financial Results and Updates on Oncology Pipeline Advancements
Company Overview: Bolt Biotherapeutics, Inc. reported its Q3 2025 financial results, highlighting its focus on developing immunotherapies for cancer through its proprietary Boltbody ISAC platform, which includes two clinical-stage candidates, BDC-3042 and BDC-4182.
Clinical Trials Update: BDC-3042, targeting tumor-associated macrophages, has shown early signs of immune activation in a Phase 1 study, while BDC-4182 is being evaluated for gastric and gastroesophageal cancers, with initial data expected in Q3 2026.
Financial Performance: The company reported a narrowed net loss of $7.1 million for Q3 2025, a significant improvement from the previous year, attributed to reduced R&D and G&A costs following a corporate restructuring.
Stock Performance: Bolt's stock has fluctuated between $4.42 and $13 over the past year, closing at $4.69 recently, with a slight increase in overnight trading.
HC Wainwright & Co. Initiates Coverage on Bolt Biotherapeutics with a Buy Rating and Sets Price Target at $7
Real-time Intelligence: Benzinga Pro offers the fastest news alerts for traders, helping them stay informed and make timely decisions in the stock market.
Community and Exclusivity: Joining Benzinga Pro connects traders with over 10,000 members and provides access to exclusive stories and insights from Benzinga reporters.
Bolt Biotherapeutics Presents Results from the Phase 1 Dose-Escalation Clinical Study of BDC-3042 at AACR Annual Meeting 2025
Clinical Study Results: BDC-3042, a novel immunotherapy developed by Bolt Biotherapeutics, demonstrated a favorable safety profile and biological activity in a Phase 1 clinical trial, with no serious adverse events reported and signs of anti-tumor activity in patients with various cancers.
Future Development Plans: The company is seeking partnerships to accelerate the development of BDC-3042, which targets dectin-2 on tumor-associated macrophages, and aims to explore its potential in combination with other therapies for improved patient outcomes.
HC Wainwright & Co. Reiterates Neutral on Bolt Biotherapeuticsto Neutral
Real-time Market Intelligence: Benzinga Pro offers the fastest and most accurate stock market alerts, helping traders stay informed and make winning trades daily.
Community of Traders: Over 10,000 serious traders are part of the Benzinga Pro community, gaining access to exclusive stories and insights from Benzinga reporters.
Bolt Biotherapeutics Reports Fourth Quarter and Full-Year 2024 Financial Results and Provides Business Update
Clinical Trials Update: Bolt Biotherapeutics is set to begin a clinical trial for BDC-4182, targeting gastric cancer, in the second quarter of 2025, while the Phase 1 trial for BDC-3042 has been fully enrolled with no dose-limiting toxicities reported.
Financial Overview: As of December 31, 2024, Bolt Biotherapeutics has a cash balance of $70.2 million, expected to fund operations and key milestones through mid-2026, despite reporting a net loss of $63.1 million for the year.
Bolt Biotherapeutics provides update on co-development collaboration with Toray
Collaboration Announcement: Bolt Biotherapeutics is collaborating with Toray Industries to develop a Boltbody Immune-Stimulating Antibody Conjugate targeting Caprin-1, a cancer target discovered by Toray, applicable to various solid tumors.
Joint Development Agreement: Under their agreement, Toray provides proprietary antibodies like TRK-950, while Bolt contributes linker-payloads from its technology platform, aiming for co-development and commercialization of the resulting product candidate.
