Alaunos Therapeutics Reports Preclinical Readout for ALN1003
Written by Emily J. Thompson, Senior Investment Analyst
Updated: 3 days ago
0mins
Alaunos Therapeutics reported an integrated preclinical readout for ALN1003, the company's investigational oral, non-hormonal, non-incretin small-molecule candidate for obesity and related metabolic disorders. The readout consolidates findings from two non-Good Laboratory Practice diet-induced obesity mouse studies previously reported on March 2, 2026 and May 18, 2026, together with newly assembled cross-study analyses presented in an accompanying non-confidential slide deck published today. Viewed together, the data show treatment-associated improvements across key biological drivers of metabolic disease: Body weight and food intake; Body composition - preferential reductions in fat mass with proportional gains in lean mass as a percentage of body weight; Insulin-resistance biology - lower fasting insulin and lower HOMA-IR, after adjustment for adiposity; Adipose endocrine signaling - significantly higher adiponectin and a higher adiponectin-to-leptin ratio; Hepatic biology - lower liver weight, lower liver-injury and cholestatic enzymes, and qualitative liver histology findings consistent with lower hepatic steatosis. The longer-duration 48-day study evaluated ALN1003 administered orally, twice daily, at a single dose level. It is in this study that the fullest expression of the multi-axis profile was observed - the coordinated metabolic profile referenced above - with treatment-associated changes spanning body weight, insulin-resistance biology, adipose endocrine signaling, and hepatic biology. The shorter 18-day dose-ranging study evaluated ALN1003 administered in drinking water at low, medium, and high dose levels. DIO Study 2 demonstrated dose-associated changes in body weight, body composition, liver weight, glucose, and total cholesterol. Interpretation of DIO Study 2 should consider dose-related reductions in water consumption and apparent dose aversion, which may confound attribution of effects solely to drug exposure in this administration paradigm; the company is pursuing formulation optimization and dedicated PK/tolerability work.
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About TCRT
Alaunos Therapeutics, Inc. is a pre-clinical obesity and metabolic disorder and clinical-stage oncology-focused cell therapy company. The Company focuses on developing small molecules that are expected to be efficacious against obesity and other metabolic disorders. The Company is engaged in developing novel small molecule-based obesity therapeutics. The Company’s operations consist primarily of conducting research and development and raising capital to fund those efforts. The Company has not generated any revenues.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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- Metabolic Health Improvements: The study showed significant improvements in insulin resistance and liver health markers in treated mice, including lower fasting insulin levels and better HOMA-IR readings, suggesting the drug's effectiveness in addressing metabolic syndrome.
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See More
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- Body Composition Improvement: In DIO Study 2, the high-dose group exhibited a 21.9% reduction in fat as a percentage of body weight (p<0.0001) and a 17.2% increase in lean mass percentage (p<0.0001), suggesting ALN1003's potential to enhance metabolic health and reduce obesity-related risks.
- Insulin Resistance Biomarkers: DIO Study 1 revealed that ALN1003 treatment was associated with significantly lower fasting insulin levels and a decrease in HOMA-IR (p=0.0006), highlighting the drug's potential in improving insulin sensitivity.
- Liver Health Improvement: In DIO Study 1, ALN1003 significantly reduced liver weight by 43% (p<0.0001) and showed marked decreases in liver function markers such as ALT and AST compared to controls, indicating a positive impact on liver health.
See More
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- Liver Health Improvement: The drug reduced liver weight by 43% compared to untreated mice, highlighting its effectiveness and potential to lower the risk of obesity-related liver diseases.
- Biochemical Indicator Improvement: Long-term administration of ALN1003 was associated with significant reductions in ALT, AST, and ALP levels, along with a trend toward lower total bilirubin, suggesting its potential in improving metabolic health.
- Future Development Plans: The company plans to pursue additional financing to support ongoing preclinical work for ALN1003 and optimize manufacturing processes, ensuring drug efficacy and safety to pave the way for future IND applications.
See More
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- Significant Weight Loss: In the DIO mouse model, ALN1003-treated mice exhibited an average weight reduction of -12.9%, indicating the drug's potential efficacy in obesity treatment.
- Liver Health Improvement: ALN1003 reduced liver weight by 43% and lowered liver injury biomarkers such as ALT and AST, suggesting a positive impact on metabolic-associated liver disease.
- Reduced Food and Water Intake: The ALN1003 treatment group consumed significantly less food (347.5g/cage vs 425.0g/cage), which may correlate with the drug's weight loss mechanism, further supporting its potential as a non-hormonal treatment.
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