Actinium Pharmaceuticals Unveils New Findings Showcasing Strong and Lasting Effectiveness of ATNM-400, a Pioneering Multi-Tumor Actinium-225 Radiotherapy, at the 32nd Annual Prostate Cancer Foundation Scientific Retreat
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Oct 24 2025
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Source: Newsfilter
ATNM-400 Overview: Actinium Pharmaceuticals' ATNM-400 is a first-in-class antibody radioconjugate targeting a non-PSMA antigen, demonstrating potent anti-tumor activity and prolonged survival in prostate cancer models resistant to standard therapies like enzalutamide and 177Lu-PSMA-617.
Efficacy and Resistance: Preclinical studies show that ATNM-400 outperforms existing treatments, achieving durable tumor control and complete regression in 40% of cases when combined with enzalutamide, highlighting its potential in overcoming treatment resistance.
Clinical Implications: The novel mechanism of ATNM-400 offers a promising alternative for patients with metastatic castration-resistant prostate cancer (mCRPC) who have limited options due to low or absent PSMA expression, addressing a significant unmet clinical need.
Future Directions: Actinium plans to explore ATNM-400's applications beyond prostate cancer, including non-small cell lung cancer (NSCLC), where it has shown potential to overcome resistance to existing therapies, further expanding its therapeutic impact.
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Analyst Views on ATNM
Wall Street analysts forecast ATNM stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for ATNM is 6.00 USD with a low forecast of 4.00 USD and a high forecast of 9.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
3 Analyst Rating
3 Buy
0 Hold
0 Sell
Strong Buy
Current: 1.220
Low
4.00
Averages
6.00
High
9.00
Current: 1.220
Low
4.00
Averages
6.00
High
9.00
About ATNM
Actinium Pharmaceuticals, Inc. specializes in the development of targeted radiotherapies. The Company is advancing its lead product candidate Actimab-A, a CD33 targeting therapeutic, as potential backbone therapy in acute myeloid leukemia (AML) and other myeloid malignancies leveraging the mutation agnostic alpha-emitter radioisotope payload Actinium-225 (Ac-225). The Company is engaged with the National Cancer Institute (NCI) under the Cooperative Research and Development Agreement (CRADA) for development of Actimab-A in AML and other myeloid malignancies. ATNM-400 is the Company's novel non-PSMA targeting Ac-225 radiotherapy for prostate cancer. Iomab-ACT, its conditioning candidate, is being developed to improve patient access and outcomes for potentially curative cell and gene therapies. Its Iomab-B program is an induction and conditioning agent prior to bone marrow transplant in patients with r/r AML, which it is seeking a potential strategic partner for the United States.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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