NCNA.O Shares Slide Below 5-Day SMA
Written by Emily J. Thompson, Senior Investment Analyst
Updated: 21 Nov 25
Source: NASDAQ.COM
Shares of NCNA.O declined sharply today, falling below the critical 5-day simple moving average (SMA), which is often viewed as a bearish signal by traders. This technical breakdown suggests a potential shift in market sentiment, indicating increased selling pressure and a lack of buying interest in the stock. Analysts are closely monitoring this movement, as it may lead to further declines if the stock fails to regain its footing above the SMA. The recent downturn could be attributed to broader market volatility and investor concerns surrounding the company's upcoming earnings report, which has heightened uncertainty among shareholders.
Analyst Views on NCNA
About NCNA
NuCana plc is a United Kingdom-based clinical-stage biopharmaceutical company. The Company is focused on developing treatment outcomes for patients with cancer by applying its ProTide technology. The Company's pipeline includes NUC-7738 and NUC-3373. NUC-7738 is an anti-cancer agent that disrupts Ribonucleic acid (RNA) polyadenylation, profoundly impacts gene expression in cancer cells and targets multiple aspects of the tumor microenvironment. NUC-7738 is in the Phase II part of a Phase I/II study which is evaluating NUC-7738 as a monotherapy in patients with advanced solid tumors and in combination with pembrolizumab in patients with melanoma. NUC-3373 is a chemical entity derived from the nucleoside analog 5-fluorouracil, a chemotherapy agent. NUC-3373 is being evaluated in a Phase Ib/II modular study (NuTide:303) of NUC-3373 in combination with the PD-1 inhibitor pembrolizumab for patients with advanced solid tumors and in combination with docetaxel for patients with lung cancer.
About the author

Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.





