What’s Driving the Surge in Immunome Stock This Monday?
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Dec 15 2025
0mins
Should l Buy IMNM?
Source: Benzinga
Stock Performance: Immunome Inc. (NASDAQ: IMNM) saw a significant stock increase of 20.87% to $23.65, with trading volume reaching 8.25 million shares, far exceeding its average of 1.50 million.
Clinical Trial Results: The Phase 3 RINGSIDE trial for varegacestat in treating progressing desmoid tumors met its primary endpoint, showing an 84% reduction in disease progression risk and a 56% objective response rate compared to 9% for placebo.
Secondary Endpoints Achieved: The trial also met all key secondary endpoints, demonstrating significant improvements in tumor volume reduction and pain intensity, with varegacestat being well-tolerated.
Future Plans: Immunome plans to submit a New Drug Application to the FDA in Q2 2026, highlighting the trial as the largest conducted for desmoid tumors and emphasizing the potential of varegacestat as a leading treatment option.
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Analyst Views on IMNM
Wall Street analysts forecast IMNM stock price to rise
11 Analyst Rating
11 Buy
0 Hold
0 Sell
Strong Buy
Current: 21.330
Low
21.00
Averages
33.20
High
40.00
Current: 21.330
Low
21.00
Averages
33.20
High
40.00
About IMNM
Immunome, Inc. is a clinical-stage targeted oncology company, which is focused on developing first-in-class and targeted therapies designed to improve outcomes for cancer patients. The Company is engaged in advancing an innovative portfolio of therapeutics in the design, development, and commercialization of targeted cancer therapies, including antibody-drug conjugate therapies (ADCs). Its advanced pipeline programs are varegacestat, a gamma secretase inhibitor which is in a Phase III trial for the treatment of desmoid tumors; IM-1021, an ROR1-targeted ADC which is in a Phase I trial, and IM-3050, a FAP-targeted radioligand. The Company's pipeline also includes IM-1617, IM-1335, and IM-1340, all of which are preclinical ADCs pursuing undisclosed targets with expression in multiple solid tumors. IM-1617 is a potential first-in-class ADC that targets an undisclosed receptor that is expressed in a range of solid tumors, including colorectal cancer and ovarian cancers.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
Immunome Grants Stock Options to New Employees
- Stock Option Grant: On March 2, 2026, Immunome granted a total of 282,000 non-statutory stock options to seven new employees, aimed at attracting and retaining talent, thereby enhancing the company's competitive position in cancer therapy.
- Exercise Price Setting: Each stock option has an exercise price of $22.21, equal to the closing price on March 2, 2026, which helps incentivize employees to grow with the company, increasing their sense of belonging and motivation.
- Vesting Schedule: The stock options will vest over four years, with 25% vesting on the one-year anniversary of the grant and the remainder vesting monthly, ensuring continued employee contributions during their service, thus enhancing team stability.
- Incentive Plan Compliance: The stock option grant complies with Nasdaq Listing Rule 5635(c)(4), indicating the company's commitment to compliance and transparency in talent acquisition and incentives, which helps boost investor confidence.
See More
Opaleye Management Sells Entire Stake in Immunome for $37.3 Million
- Stake Sale Overview: Opaleye Management sold its entire 3,185,000 shares of Immunome in Q4 2025 for an estimated $37.3 million, resulting in a complete exit from the position and a corresponding $37.3 million drop in quarter-end asset value.
- Portfolio Impact: This transaction reduced Immunome's representation in Opaleye's portfolio from 5.3% to 0%, indicating a total divestment that could influence the fund's future investment strategy.
- Market Performance Analysis: As of February 17, 2026, Immunome shares were priced at $22.69, reflecting a 128.5% increase over the past year, yet a 9% decline over the last two years, highlighting the stock's volatility that may affect investor confidence.
- Investor Strategy Recommendation: Given the volatility of biotech stocks, retail investors are advised to consider biotech ETFs to spread risk, allowing them to benefit from long-term industry growth while mitigating portfolio volatility.
See More
Opaleye Management Exits Entire Stake in Immunome
- Complete Exit: Opaleye Management sold all 3,185,000 shares of Immunome in Q4 2025 for an estimated $37.30 million, reflecting a full exit that resulted in a 4.92% decrease in its assets under management (AUM).
- Portfolio Shift: The sale eliminated Immunome's representation in Opaleye's portfolio, which previously accounted for 5.3% of AUM, indicating a significant strategic shift that may influence future investment decisions.
- Stock Volatility Impact: While Immunome's stock surged 128.5% over the past year, it has declined approximately 9% over the last two years, highlighting the stock's volatility and prompting Opaleye to reassess its investment strategy.
- Market Outlook: Despite Immunome's strong performance in the past year, analysts recommend that investors consider more stable biotech ETFs to mitigate risk, reflecting a cautious market sentiment towards individual biotech stocks.
See More
Immunome Reports FY Loss and Declining Revenue Amid Public Offering
- Disappointing Earnings: Immunome's reported GAAP EPS of -$2.43 misses expectations by $0.16, indicating challenges in profitability that could undermine investor confidence and affect stock performance.
- Declining Collaboration Revenue: The company reported collaboration revenue of $6.9 million, a 23.7% year-over-year decline, falling short of the expected $7.7 million, which may negatively impact future liquidity and operational funding.
- Maintaining Strong Buy Rating: Despite the disappointing earnings, Immunome continues to maintain a 'Strong Buy' rating on the successful RINGSIDE trial with Varegacestat, reflecting confidence in its R&D pipeline that may attract long-term investors.
- Proposed Public Offering: Immunome has announced a proposed public offering aimed at raising funds to support its R&D projects, which may exert short-term pressure on the stock price but is expected to enhance financial stability in the long run.
See More
Redmile Group Increases Stake in Immunome
- Share Acquisition: Redmile Group disclosed a purchase of 695,000 shares of Immunome in Q4 2025, with an estimated transaction value of approximately $12.20 million, indicating strong confidence in the company's future prospects.
- Increased Ownership: This acquisition raises Redmile Group's stake in Immunome to 9.05%, highlighting its significance within the investment portfolio and reinforcing long-term investment confidence in Immunome.
- Strong Market Performance: As of February 17, 2026, Immunome shares were priced at $22.69, reflecting a remarkable 120% increase over the past year, significantly outperforming the S&P 500's 13% gain, showcasing market recognition of its potential.
- Funding and R&D Progress: Immunome successfully raised $400 million last year to support its oncology pipeline and plans to file a New Drug Application in Q2 2026, indicating positive clinical advancements and a promising market outlook.
See More
Redmile Group Increases Immunome Holdings
- Share Acquisition: Redmile Group increased its holdings in Immunome by 695,000 shares during Q4 2025, with an estimated trade value of $12.20 million, indicating strong confidence in the company's future prospects.
- Value Growth: By quarter-end, Redmile's total position in Immunome rose to $122.83 million, reflecting a $64.01 million increase driven by both share purchases and stock price appreciation.
- Market Position: Immunome focuses on developing antibody-based therapies for oncology and infectious diseases, with its differentiated pipeline and expertise in antibody engineering providing a competitive edge that attracts investor interest.
- Future Outlook: Immunome plans to file a New Drug Application in Q2 2026, and if its varegacestat receives approval, it could shift market perceptions of its valuation, propelling the company into a commercialization phase.
See More
Immunome Grants Stock Options to New Employees
- Stock Option Grant: On March 2, 2026, Immunome granted a total of 282,000 non-statutory stock options to seven new employees, aimed at attracting and retaining talent, thereby enhancing the company's competitive position in cancer therapy.
- Exercise Price Setting: Each stock option has an exercise price of $22.21, equal to the closing price on March 2, 2026, which helps incentivize employees to grow with the company, increasing their sense of belonging and motivation.
- Vesting Schedule: The stock options will vest over four years, with 25% vesting on the one-year anniversary of the grant and the remainder vesting monthly, ensuring continued employee contributions during their service, thus enhancing team stability.
- Incentive Plan Compliance: The stock option grant complies with Nasdaq Listing Rule 5635(c)(4), indicating the company's commitment to compliance and transparency in talent acquisition and incentives, which helps boost investor confidence.
See More
Opaleye Management Sells Entire Stake in Immunome for $37.3 Million
- Stake Sale Overview: Opaleye Management sold its entire 3,185,000 shares of Immunome in Q4 2025 for an estimated $37.3 million, resulting in a complete exit from the position and a corresponding $37.3 million drop in quarter-end asset value.
- Portfolio Impact: This transaction reduced Immunome's representation in Opaleye's portfolio from 5.3% to 0%, indicating a total divestment that could influence the fund's future investment strategy.
- Market Performance Analysis: As of February 17, 2026, Immunome shares were priced at $22.69, reflecting a 128.5% increase over the past year, yet a 9% decline over the last two years, highlighting the stock's volatility that may affect investor confidence.
- Investor Strategy Recommendation: Given the volatility of biotech stocks, retail investors are advised to consider biotech ETFs to spread risk, allowing them to benefit from long-term industry growth while mitigating portfolio volatility.
See More
Opaleye Management Exits Entire Stake in Immunome
- Complete Exit: Opaleye Management sold all 3,185,000 shares of Immunome in Q4 2025 for an estimated $37.30 million, reflecting a full exit that resulted in a 4.92% decrease in its assets under management (AUM).
- Portfolio Shift: The sale eliminated Immunome's representation in Opaleye's portfolio, which previously accounted for 5.3% of AUM, indicating a significant strategic shift that may influence future investment decisions.
- Stock Volatility Impact: While Immunome's stock surged 128.5% over the past year, it has declined approximately 9% over the last two years, highlighting the stock's volatility and prompting Opaleye to reassess its investment strategy.
- Market Outlook: Despite Immunome's strong performance in the past year, analysts recommend that investors consider more stable biotech ETFs to mitigate risk, reflecting a cautious market sentiment towards individual biotech stocks.
See More
Immunome Reports FY Loss and Declining Revenue Amid Public Offering
- Disappointing Earnings: Immunome's reported GAAP EPS of -$2.43 misses expectations by $0.16, indicating challenges in profitability that could undermine investor confidence and affect stock performance.
- Declining Collaboration Revenue: The company reported collaboration revenue of $6.9 million, a 23.7% year-over-year decline, falling short of the expected $7.7 million, which may negatively impact future liquidity and operational funding.
- Maintaining Strong Buy Rating: Despite the disappointing earnings, Immunome continues to maintain a 'Strong Buy' rating on the successful RINGSIDE trial with Varegacestat, reflecting confidence in its R&D pipeline that may attract long-term investors.
- Proposed Public Offering: Immunome has announced a proposed public offering aimed at raising funds to support its R&D projects, which may exert short-term pressure on the stock price but is expected to enhance financial stability in the long run.
See More
Redmile Group Increases Stake in Immunome
- Share Acquisition: Redmile Group disclosed a purchase of 695,000 shares of Immunome in Q4 2025, with an estimated transaction value of approximately $12.20 million, indicating strong confidence in the company's future prospects.
- Increased Ownership: This acquisition raises Redmile Group's stake in Immunome to 9.05%, highlighting its significance within the investment portfolio and reinforcing long-term investment confidence in Immunome.
- Strong Market Performance: As of February 17, 2026, Immunome shares were priced at $22.69, reflecting a remarkable 120% increase over the past year, significantly outperforming the S&P 500's 13% gain, showcasing market recognition of its potential.
- Funding and R&D Progress: Immunome successfully raised $400 million last year to support its oncology pipeline and plans to file a New Drug Application in Q2 2026, indicating positive clinical advancements and a promising market outlook.
See More
Redmile Group Increases Immunome Holdings
- Share Acquisition: Redmile Group increased its holdings in Immunome by 695,000 shares during Q4 2025, with an estimated trade value of $12.20 million, indicating strong confidence in the company's future prospects.
- Value Growth: By quarter-end, Redmile's total position in Immunome rose to $122.83 million, reflecting a $64.01 million increase driven by both share purchases and stock price appreciation.
- Market Position: Immunome focuses on developing antibody-based therapies for oncology and infectious diseases, with its differentiated pipeline and expertise in antibody engineering providing a competitive edge that attracts investor interest.
- Future Outlook: Immunome plans to file a New Drug Application in Q2 2026, and if its varegacestat receives approval, it could shift market perceptions of its valuation, propelling the company into a commercialization phase.
See More
