NeOnc Technologies Holdings, Inc. Appoints Dr. Josh Neman as Chief Clinical Officer to Advance Clinical Strategy and Translational Oncology Programs
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Jun 06 2025
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Should l Buy NTHI?
Source: Newsfilter
New Appointment: NeOnc Technologies has appointed Dr. Josh Neman as Chief Clinical Officer to lead its clinical development strategy, particularly for the promising brain tumor treatment NEO100, which is nearing completion of its Phase 2a trial ahead of schedule.
Innovative Approaches: The company aims to enhance drug delivery through AI and quantum computing while expanding research collaborations, reflecting a commitment to advancing precision therapies for CNS cancers.
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About NTHI
NeOnc Technologies Holdings, Inc. is a clinical-stage biopharmaceutical company. The Company is focused on establishing treatments for intracranial malignancies, such as aggressive cancers located in the brain. It is the developer of a novel molecular technology that provides enhanced targeted delivery of technologies for treating central nervous system diseases. It is developing novel drug delivery methods to be used in combination with novel drug candidates. The Company has two lead products in development: NEO100 and NEO212. NEO100 is a purified form of perillyl acid (POH) which is administered to brain cancer patients via intranasal delivery. NEO212 is a covalently conjugated molecule combining the chemotherapeutic drug temozolomide with perillyl alcohol. NEO212 is undergoing development towards intranasal application specifically for patients with uncontrolled brain metastases derived from peripheral tumors (lung, breast, skin, and others).
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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- Investor Confidence Boosted: The $10 million investment from Cinctive Capital reflects strong confidence in NeOnc's technology and clinical assets, particularly underscored by the leadership of Co-Founder Rich Schimel, enhancing the strategic significance of this investment and market recognition of the company.
- Clinical Trials Acceleration: NeOnc stated that this funding will provide essential capital to accelerate its clinical trials, especially for its NEO100 and NEO212 therapies in Phase II, which aim to bypass the blood-brain barrier and address significant challenges in CNS cancer treatment.
- Patent Protection Advantage: NeOnc's NEO™ drug development platform, with patent protections extending to 2038, demonstrates the company's long-term potential in innovative drug development, which is expected to provide strong support for future market competition.
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See More
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- Clinical Results Update: NeOnc Technologies reports that its NEO100 therapy achieved a significant radiographic remission rate of 24% in 25 patients, which is a 300% increase over the typical 8% seen with salvage therapies, indicating strong efficacy and competitive potential in the market.
- Survival Rate Improvement: Among patients treated with NEO100, 36% remained alive 18 months post-treatment, suggesting that this therapy may provide durable survival benefits in heavily pretreated populations, thereby altering treatment strategies.
- No Significant Toxicity: The intranasal administration of NEO100 has shown no significant toxicity even with prolonged use, ensuring patient safety and providing strong support for its clinical application.
- Broad Treatment Prospects: As the dataset expands, NEO100 is emerging as a potential first-in-class CNS-penetrant metabolic therapy, marking a possible paradigm shift in the treatment of IDH1-mutant high-grade gliomas and pushing the industry towards more effective treatment options.
See More
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- Significant Efficacy: Among 25 patients treated with NEO100, 6 (24%) achieved significant radiographic remission, representing a 300% increase over the typical 8% response rate seen with salvage therapies, indicating NEO100's potential as an effective option for recurrent IDH1-mutant high-grade gliomas.
- Survival Rate Improvement: 36% of patients demonstrated survival of 18 months or longer post-NEO100 treatment, showcasing the therapy's potential for long-term survival in heavily pretreated populations, which may shift treatment paradigms in this field.
- No Significant Toxicity: The intranasal administration of NEO100 has shown no significant toxicity even with prolonged and chronic dosing, indicating a high safety profile that could enhance patient treatment experiences.
- Expanded Clinical Data: The growing clinical cohort reinforces the treatment's effectiveness, bolstering confidence in NEO100 as a first-in-class CNS-penetrant metabolic therapy, potentially driving significant advancements in neuro-oncology.
See More
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- Research Collaboration Findings: A study from the University of Southern California demonstrates that ultrasound significantly enhances NEO100's therapeutic potency, driving strong antitumor effects across various brain tumor types, indicating its potential for clinical application.
- Technological Innovation: Utilizing an AI-driven, 3D bioprinting New Approach Methodology, researchers rapidly generate physiologically relevant patient-derived tumor organoids within hours, significantly accelerating biomedical research and aligning with NIH objectives to reduce animal testing.
- Clinical Trial Prospects: Validation studies reveal that NEO100 exhibits markedly enhanced tumor-killing activity when combined with focused ultrasound, supporting its advancement into future clinical trials for a wide range of brain tumors, thereby broadening its commercial and clinical opportunities.
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