Natera Presents Significant DFS Improvement Data from ALTAIR Trial at ASCO GI 2026
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Jan 06 2026
0mins
Should l Buy NTRA?
Source: Businesswire
- Clinical Trial Update: Natera will present new analysis from the ALTAIR trial at ASCO GI 2026, showing a median disease-free survival (DFS) of 9.23 months for FTD/TPI treatment compared to 5.55 months for placebo, with a hazard ratio of 0.75 and a p-value of 0.0406, indicating significant efficacy in colorectal cancer patients.
- Importance of Data Analysis: This analysis, based on a post-hoc blinded central radiographic review that reclassified certain cases, provides a statistically significant DFS improvement compared to the previously reported overall ALTAIR analysis, highlighting the potential of FTD/TPI in clinical applications.
- ctDNA Monitoring Study: Natera will also showcase the prognostic value of Signatera levels in relapse risk stratification, revealing that patients with Signatera levels doubling within one month experienced approximately 40% shorter recurrence-free survival (RFS), offering new insights for personalized treatment.
- Future Outlook: Natera's research findings not only demonstrate its leadership in ctDNA dynamic monitoring but may also drive more precise risk stratification and cancer management strategies, further solidifying its market leadership in precision medicine.
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Analyst Views on NTRA
Wall Street analysts forecast NTRA stock price to rise
17 Analyst Rating
15 Buy
2 Hold
0 Sell
Strong Buy
Current: 207.835
Low
172.00
Averages
252.88
High
300.00
Current: 207.835
Low
172.00
Averages
252.88
High
300.00
About NTRA
Natera, Inc. provides cell-free DNA (cfDNA) and genetic testing, dedicated to oncology, women’s health, and organ health. The Company's cfDNA technology platform combines novel molecular biology techniques with bioinformatics software and artificial intelligence. It has leveraged its platform to develop non-invasive prenatal test on the market (Panorama), the first tumor-specific assay for truly individualized cancer care (Signatera), best-in-class rejection assessment for kidney transplantation (Prospera) and others. In the women’s health space, it develops and commercializes non- or minimally- invasive tests to evaluate risk for, and thereby enable early detection of, a range of genetic conditions, such as Down syndrome. In oncology, it is focused on detecting molecular residual disease and recurrence monitoring in solid tumors, among others. In organ health, it offers tests to assess kidney, heart, and lung transplant rejection as well as genetic testing for chronic kidney disease.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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- Innovative Technology Application: The test integrates cell-free DNA and other clinical data to offer personalized risk assessments, surpassing traditional clinical characteristic evaluations, thereby enhancing the precision and effectiveness of prenatal care.
- Industry-Wide Impact: Through the EDEN study, Natera aims not only to enhance its market competitiveness but also to lead technological innovation in the prenatal screening sector, potentially elevating industry standards and development.
See More
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- Market Comparison: Compared to the S&P 500 ETF (SPY) with an RSI of 52.7, NTRA's oversold status may attract bullish investors' attention, especially given the overall stronger market performance.
- Historical Performance: NTRA shares have a 52-week low of $125.38 and a high of $256.36, with the last trade at $205.61, indicating potential price volatility that investors should monitor for rebound opportunities.
- Investor Sentiment: Despite the current low stock price, investor sentiment may shift to optimism due to the oversold signal, and if market sentiment improves, NTRA's stock price could rebound, further impacting the company's market performance.
See More
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- FDA Application Submission: Natera has submitted a premarket approval application for Signatera™CDx to the FDA, marking a significant step toward making MRD-guided treatment a reality for muscle-invasive bladder cancer patients, potentially becoming the first companion diagnostic MRD test if approved.
- Strong Market Demand: Bladder cancer is the sixth most common cancer in the U.S., with muscle-invasive cases representing 20-25% of new diagnoses; the introduction of Signatera™CDx will aid in identifying high-recurrence-risk patients, enabling more effective personalized treatment options.
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