Myriad Genetics and SOPHiA GENETICS to Develop an Innovative Companion Diagnostic Offering in Liquid Biopsy
Strategic Collaboration: Myriad Genetics and SOPHiA GENETICS have formed a partnership to develop a global liquid biopsy companion diagnostic test, leveraging Myriad's lab capabilities and SOPHiA's extensive network of over 800 institutions worldwide.
Focus on Liquid Biopsy: The collaboration will initially concentrate on the MSK-ACCESS® test, which detects genomic alterations from a blood sample, aiming to enhance patient access to personalized healthcare solutions and support pharmaceutical partners in key regulated markets.
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- FDA Approval: Myriad Genetics' MyChoice CDx Test has received FDA approval as a companion diagnostic for GSK's Zejula, based on final data from the PRIMA trial, ensuring precise treatment decisions for advanced ovarian cancer patients.
- Critical Data Support: The MyChoice CDx Test was used in the PRIMA trial to determine homologous recombination deficiency (HRD) status, with nearly half of women with advanced ovarian cancer being HRD-positive, highlighting the importance of accurate identification.
- Market Leadership: The MyChoice CDx Test is now the only FDA-approved companion diagnostic for Zejula in the U.S., utilizing next-generation sequencing to assess BRCA1/2 genes and tumor genomic instability scores, further solidifying Myriad's leadership in ovarian cancer diagnostics.
- Personalized Treatment Outlook: The FDA decision marks a significant milestone for Myriad in precision medicine, expanding its role in personalized cancer care and ensuring treatment decisions are guided by robust genomic insights.
New Additions to S&P 500: Vertiv Holdings, Lumentum Holdings, Coherent, and Echosstar are set to join the S&P 500 index.
Market Impact: The inclusion of these companies may influence market dynamics and investor strategies as they become part of a major stock index.

New Additions to S&P 500: Vert Holdings, Lumentum Holdings, CohereNT, and EchoStar are set to join the S&P 500 index.
Other Index Changes: Additional companies will be added to the S&P 100, S&P MidCap 400, and S&P SmallCap 600 indices.
- AMD and Meta Partnership: AMD has signed a multi-year deal with Meta to supply up to 6 gigawatts of GPUs, which is expected to significantly enhance AMD's market share in AI data centers; while the deal's cost remains unclear, it includes a performance-based warrant potentially involving up to 160 million shares of AMD stock.
- Home Depot Earnings Beat: Home Depot reported fourth-quarter adjusted earnings of $2.72 per share on revenues of $38.20 billion, exceeding analyst expectations of $2.54 per share and $38.12 billion in revenue, indicating strong performance in the home improvement sector.
- Hims & Hers Disappoints: Shares of Hims & Hers Health fell nearly 7% after the company projected first-quarter revenues between $600 million and $625 million, significantly below the $653 million expected by analysts, with adjusted EBITDA also falling short of estimates, highlighting challenges ahead.
- BWX Technologies Strong Results: BWX Technologies reported fourth-quarter earnings of $1.08 per share, surpassing the $0.89 expected by analysts, with revenue of $885.8 million also exceeding the $837.5 million estimate, showcasing its competitive strength in the nuclear components and fuel supply market.
- Strong Earnings Performance: Keysight Technologies reported earnings per share of $2.17, exceeding Wall Street's expectation of $2, demonstrating robust profitability that boosts investor confidence.
- Significant Revenue Growth: The quarterly revenue reached $1.6 billion, surpassing the analyst consensus of $1.54 billion, indicating successful business expansion and strong market demand, further solidifying its market position.
- Stock Price Surge: Keysight's shares jumped 16.8% to $286.03 in pre-market trading, reflecting a positive investor reaction to the company's financial performance, which may attract more investor interest.
- Market Dynamics Impact: Keysight's strong results could influence the performance of other related stocks, particularly in the technology and electronics sectors, signaling an overall improvement in market sentiment.

- Earnings Beat: Myriad Genetics reported a non-GAAP EPS of $0.04 for Q4 2025, exceeding expectations by $0.06, with revenue of $209.8 million surpassing forecasts by $2.24 million, indicating strong growth potential in the cancer care sector.
- 2026 Revenue Target: The company has set a revenue target of $860 million to $880 million for 2026, with Q1 2026 revenue expected to range from $200 million to $203 million, reflecting a 2% to 4% growth despite challenges in year-over-year comparisons.
- Market Growth Drivers: CEO Samraat Raha highlighted that Q4 test results reached 382,000, with MyRisk in oncology growing at 14% year-over-year and MyRisk for unaffected individuals at 11%, demonstrating robust demand in high-growth market segments.
- Challenges and Strategies: While facing challenges in recovering prenatal testing volumes, management is actively rebuilding affected accounts to ensure future revenue growth, expressing confidence in sustaining high single-digit growth rates into 2027 and beyond.









