KPTI Shares Drop in Pre-Market Trading Despite Karyopharm's Myelofibrosis Treatment Achieving Key Goal — Retail Investors Skeptical of FDA Approval
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Mar 24 2026
0mins
Source: stocktwits
Phase 3 Trial Results: Karyopharm's Phase 3 SENTRY trial showed that 50% of patients treated with selinexor combined with ruxolitinib achieved significant spleen volume reduction, compared to 28% with ruxolitinib alone, indicating promising efficacy for treating myelofibrosis.
Private Placement Announcement: Karyopharm announced a private placement deal with RA Capital Management to raise approximately $30 million, which is expected to support operations and planned clinical trials into the third quarter of 2026.
Stock Performance: Following the positive trial results, Karyopharm's stock initially gained but later reversed to a 13% decline in pre-market trading, reflecting mixed sentiment among investors regarding the FDA's potential approval of the drug.
Future Plans: The company plans to meet with the FDA to discuss next steps, including the possibility of filing a supplemental new drug application (sNDA) based on the trial data, which they believe could significantly improve clinical outcomes for patients.
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Analyst Views on KPTI
Wall Street analysts forecast KPTI stock price to rise
6 Analyst Rating
5 Buy
1 Hold
0 Sell
Strong Buy
Current: 9.110
Low
6.00
Averages
13.83
High
21.00
Current: 9.110
Low
6.00
Averages
13.83
High
21.00
About KPTI
Karyopharm Therapeutics Inc. is a commercial-stage pharmaceutical company. The Company is engaged in the discovery, development and commercialization of drugs directed against nuclear export for the treatment of cancer. It is developing and commercializing novel, small molecule XPO1 inhibitor compounds that inhibit the nuclear export protein exportin 1 (XPO1). Its lead asset, XPOVIO (selinexor), is marketed in combination with bortezomib and dexamethasone for the treatment of adult patients with multiple myeloma who have received at least one prior therapy. XPOVIO is also marketed for treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL). The Company is engaged in evaluating selinexor in certain hematological and solid tumor malignancies, including myelofibrosis, endometrial cancer and multiple myeloma. The Company’s product candidate, eltanexor, is an oral SINE compound like selinexor, that selectively blocks the nuclear export protein XPO1.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
Karyopharm to Speak at 2026 Jefferies Global Healthcare Conference
- Management Participation: Karyopharm Therapeutics' senior management team will participate in a fireside chat at the 2026 Jefferies Global Healthcare Conference on June 4, 2026, in New York, showcasing the company's innovative advancements in cancer therapies.
- Live Webcast Available: The fireside chat will be accessible via a live webcast on the company's website under the 'Investors & Media' section, allowing investors to engage with the company's updates and access a replay post-event.
- Leading Therapeutic Solution: Karyopharm's lead therapy, XPOVIO® (selinexor), is the first-in-class export inhibitor approved in the U.S. for relapsed or refractory multiple myeloma and in over 50 countries, highlighting its global market potential.
- Research and Development Opportunities: The company is exploring XPO1 inhibition across various hematologic and solid tumors, including myelofibrosis and TP53 wild-type endometrial cancer, indicating its ongoing innovation and expansion potential in cancer treatment.
See More
Karyopharm Therapeutics Q1 2026 Earnings Call Insights
- Clinical Trial Progress: Karyopharm reported top-line results from the Phase III SENTRY trial in Q1, with a spleen response rate of 50% for the combination therapy, significantly higher than the 28% for ruxolitinib alone, providing robust data to enhance the company's competitive position in the myelofibrosis market.
- Financial Performance Boost: Total revenue for the first quarter reached $35.1 million, up from $30 million in the prior year, primarily driven by an increase in U.S. XPOVIO net product revenue from $21.1 million to $29.2 million, indicating strong sales performance.
- Future Outlook: The company expects total revenue in the range of $130 million to $150 million for 2026, while anticipating combined R&D and SG&A expenses between $230 million and $245 million, reflecting ongoing investments in R&D to drive future growth.
- Liquidity Position: Karyopharm ended the quarter with $91.2 million in cash and cash equivalents, including approximately $50 million raised this quarter, ensuring operational flexibility through upcoming clinical and regulatory catalysts.
See More
Karyopharm Q1 Earnings Beat Expectations
- Earnings Highlights: Karyopharm Therapeutics reported a Q1 GAAP EPS of -$1.24, beating expectations by $0.25, with revenue of $35.07 million reflecting a 16.8% year-over-year increase, surpassing estimates by $3.67 million, indicating strong performance in revenue growth.
- Product Revenue Analysis: For the quarter ended March 31, 2026, U.S. net product revenue reached $29.2 million, up from $21.1 million in the same quarter of 2025, although demand for XPOVIO decreased due to new competitive entrants, highlighting challenges in market competition.
- Royalty Revenue Growth: Royalty revenue increased to $1.9 million in Q1 2026 compared to $1.7 million in Q1 2025, indicating that selinexor's approval in over 50 ex-U.S. countries and territories has strengthened the company's international market position.
- Cash Flow Status: As of March 31, 2026, the company reported total cash, cash equivalents, and restricted cash of $91.2 million, including approximately $50 million raised from private placements and open market sales, a significant increase from $64.1 million as of December 31, 2025, demonstrating positive progress in fundraising efforts.
See More
Karyopharm Reports Q1 2026 Financial Results and Clinical Progress
- Clinical Trial Progress: Karyopharm has completed enrollment in the Phase 3 XPORT-EC-042 trial for endometrial cancer, with topline data expected in mid-2026, which will establish a foundation for further advancements in cancer treatment.
- Improved Financial Performance: Total revenue for Q1 2026 was $35.1 million, a 17% increase from $30 million in Q1 2025, with net product revenue from XPOVIO at $29.2 million, indicating strong market performance and increased product demand.
- Annual Revenue Guidance Reaffirmed: The company reaffirmed its total revenue guidance for 2026 at $130 million to $150 million, including net product revenue guidance for XPOVIO at $115 million to $130 million, reflecting management's confidence in future performance and market potential.
- Operational Efficiency Improvement: The operating loss for Q1 was $26.8 million, a 20% improvement from $33.3 million in Q1 2025, demonstrating positive progress in cost management and operational efficiency, which enhances financial stability.
See More
Karyopharm Therapeutics Set to Announce Q1 Earnings Results
- Earnings Announcement: Karyopharm Therapeutics (KPTI) is set to release its Q1 2023 earnings report on May 14 before market open, with consensus EPS estimated at -$1.49 and revenue expected to reach $31.4 million, reflecting a 4.6% year-over-year increase.
- Earnings Estimate Changes: Over the last three months, EPS estimates have seen one upward revision with no downward adjustments, while revenue estimates have faced three downward revisions, indicating a cautious market outlook on the company's performance.
- Clinical Trial Progress: Karyopharm has achieved positive top-line results from its Phase III SENTRY trial in myelofibrosis, which is expected to support label expansion for Xpovio, potentially opening new revenue streams for the company in the future.
- Funding Activity: The company recently raised $30 million through private financing, resulting in an 18% stock price increase, reflecting market confidence in its growth potential, particularly in drug development and market expansion.
See More
Karyopharm to Participate in Investor Conferences
- Investor Conference Schedule: Karyopharm Therapeutics will participate in the H.C. Wainwright 4th Annual BioConnect Investor Conference on May 19, 2026, at 9:00 AM, showcasing its latest advancements in cancer treatment to attract more investor interest in its innovative therapies.
- Global Healthcare Conference Participation: On the same day, Karyopharm will also attend the RBC 2026 Global Healthcare Conference at 3:35 PM, further enhancing the company's visibility among investors and demonstrating its leadership in the cancer treatment sector.
- Live Webcast Availability: The live webcast of these sessions will be accessible through the company's website under the
See More
Karyopharm to Speak at 2026 Jefferies Global Healthcare Conference
- Management Participation: Karyopharm Therapeutics' senior management team will participate in a fireside chat at the 2026 Jefferies Global Healthcare Conference on June 4, 2026, in New York, showcasing the company's innovative advancements in cancer therapies.
- Live Webcast Available: The fireside chat will be accessible via a live webcast on the company's website under the 'Investors & Media' section, allowing investors to engage with the company's updates and access a replay post-event.
- Leading Therapeutic Solution: Karyopharm's lead therapy, XPOVIO® (selinexor), is the first-in-class export inhibitor approved in the U.S. for relapsed or refractory multiple myeloma and in over 50 countries, highlighting its global market potential.
- Research and Development Opportunities: The company is exploring XPO1 inhibition across various hematologic and solid tumors, including myelofibrosis and TP53 wild-type endometrial cancer, indicating its ongoing innovation and expansion potential in cancer treatment.
See More
Karyopharm Therapeutics Q1 2026 Earnings Call Insights
- Clinical Trial Progress: Karyopharm reported top-line results from the Phase III SENTRY trial in Q1, with a spleen response rate of 50% for the combination therapy, significantly higher than the 28% for ruxolitinib alone, providing robust data to enhance the company's competitive position in the myelofibrosis market.
- Financial Performance Boost: Total revenue for the first quarter reached $35.1 million, up from $30 million in the prior year, primarily driven by an increase in U.S. XPOVIO net product revenue from $21.1 million to $29.2 million, indicating strong sales performance.
- Future Outlook: The company expects total revenue in the range of $130 million to $150 million for 2026, while anticipating combined R&D and SG&A expenses between $230 million and $245 million, reflecting ongoing investments in R&D to drive future growth.
- Liquidity Position: Karyopharm ended the quarter with $91.2 million in cash and cash equivalents, including approximately $50 million raised this quarter, ensuring operational flexibility through upcoming clinical and regulatory catalysts.
See More
Karyopharm Q1 Earnings Beat Expectations
- Earnings Highlights: Karyopharm Therapeutics reported a Q1 GAAP EPS of -$1.24, beating expectations by $0.25, with revenue of $35.07 million reflecting a 16.8% year-over-year increase, surpassing estimates by $3.67 million, indicating strong performance in revenue growth.
- Product Revenue Analysis: For the quarter ended March 31, 2026, U.S. net product revenue reached $29.2 million, up from $21.1 million in the same quarter of 2025, although demand for XPOVIO decreased due to new competitive entrants, highlighting challenges in market competition.
- Royalty Revenue Growth: Royalty revenue increased to $1.9 million in Q1 2026 compared to $1.7 million in Q1 2025, indicating that selinexor's approval in over 50 ex-U.S. countries and territories has strengthened the company's international market position.
- Cash Flow Status: As of March 31, 2026, the company reported total cash, cash equivalents, and restricted cash of $91.2 million, including approximately $50 million raised from private placements and open market sales, a significant increase from $64.1 million as of December 31, 2025, demonstrating positive progress in fundraising efforts.
See More
Karyopharm Reports Q1 2026 Financial Results and Clinical Progress
- Clinical Trial Progress: Karyopharm has completed enrollment in the Phase 3 XPORT-EC-042 trial for endometrial cancer, with topline data expected in mid-2026, which will establish a foundation for further advancements in cancer treatment.
- Improved Financial Performance: Total revenue for Q1 2026 was $35.1 million, a 17% increase from $30 million in Q1 2025, with net product revenue from XPOVIO at $29.2 million, indicating strong market performance and increased product demand.
- Annual Revenue Guidance Reaffirmed: The company reaffirmed its total revenue guidance for 2026 at $130 million to $150 million, including net product revenue guidance for XPOVIO at $115 million to $130 million, reflecting management's confidence in future performance and market potential.
- Operational Efficiency Improvement: The operating loss for Q1 was $26.8 million, a 20% improvement from $33.3 million in Q1 2025, demonstrating positive progress in cost management and operational efficiency, which enhances financial stability.
See More
Karyopharm Therapeutics Set to Announce Q1 Earnings Results
- Earnings Announcement: Karyopharm Therapeutics (KPTI) is set to release its Q1 2023 earnings report on May 14 before market open, with consensus EPS estimated at -$1.49 and revenue expected to reach $31.4 million, reflecting a 4.6% year-over-year increase.
- Earnings Estimate Changes: Over the last three months, EPS estimates have seen one upward revision with no downward adjustments, while revenue estimates have faced three downward revisions, indicating a cautious market outlook on the company's performance.
- Clinical Trial Progress: Karyopharm has achieved positive top-line results from its Phase III SENTRY trial in myelofibrosis, which is expected to support label expansion for Xpovio, potentially opening new revenue streams for the company in the future.
- Funding Activity: The company recently raised $30 million through private financing, resulting in an 18% stock price increase, reflecting market confidence in its growth potential, particularly in drug development and market expansion.
See More
Karyopharm to Participate in Investor Conferences
- Investor Conference Schedule: Karyopharm Therapeutics will participate in the H.C. Wainwright 4th Annual BioConnect Investor Conference on May 19, 2026, at 9:00 AM, showcasing its latest advancements in cancer treatment to attract more investor interest in its innovative therapies.
- Global Healthcare Conference Participation: On the same day, Karyopharm will also attend the RBC 2026 Global Healthcare Conference at 3:35 PM, further enhancing the company's visibility among investors and demonstrating its leadership in the cancer treatment sector.
- Live Webcast Availability: The live webcast of these sessions will be accessible through the company's website under the
See More
