Immunocore Holdings Shares Show Oversold Signal
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Apr 27 2026
0mins
Source: NASDAQ.COM
- Oversold Indicator Analysis: Immunocore Holdings PLC's relative strength index (RSI) has dropped to 29.5, indicating that the stock has entered oversold territory, which may attract bullish investors looking for buying opportunities, reflecting that the recent heavy selling is gradually exhausting.
- Price Fluctuation Details: The company's stock price hit a low of $28.435, with the current trading price at $28.56, only $1.12 above the 52-week low of $27.44, indicating market interest and potential rebound opportunities for the stock.
- Market Comparison Analysis: Compared to the current RSI of 68.0 for the S&P 500 ETF (SPY), IMCR's low RSI value may suggest that its relative value is undervalued, prompting investors to consider increasing their positions to capture future rebounds.
- Historical Performance Review: IMCR's 52-week high stands at $40.7147, and the current stock price shows a significant gap from this peak, reflecting fluctuations in market confidence that may provide potential buying opportunities for investors.
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Analyst Views on IMCR
Wall Street analysts forecast IMCR stock price to rise
9 Analyst Rating
7 Buy
2 Hold
0 Sell
Strong Buy
Current: 28.550
Low
37.00
Averages
64.56
High
100.00
Current: 28.550
Low
37.00
Averages
64.56
High
100.00
About IMCR
Immunocore Holdings plc is a United Kingdom-based commercial-stage biotechnology company. The Company is engaged in the development of TCR bispecific immunotherapies, ImmTAX, which immunes mobilizing monoclonal TCRs against X disease, designed to treat a range of diseases, including cancer, autoimmune and infectious disease. The Company has a pipeline of clinical-stage programs in oncology and infectious diseases, as well as numerous pre-clinical projects. Its lead product, KIMMTRAK, is a TCR therapeutic for the treatment of patients with unresectable or metastatic uveal melanoma (mUM), in the United States, European Union, Canada, Australia and the United Kingdom. Its pipeline products include Brenetafusp, IMC-P115C, IMC-T119C, IMC-R117C, IMC-M113V, IMC-I109V, IMC-S118AI, and IMC-U120AI, among others. Its clinical programs are being conducted with patients with a range of cancers including melanoma, ovarian, lung, colorectal and others.
About the author

Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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- Clinical Trial Results: Immunocore presented positive Phase 1/2 trial data for Brenetafusp at the 2026 ASCO annual meeting, showing a median overall survival (OS) of 14.3 months for 66 heavily pretreated melanoma patients, with a 6-month OS rate of 87% and a 12-month OS rate of 57%, indicating significant survival benefits for patients resistant to first-line treatments.
- Disease Control Rate: The disease control rate (DCR) for patients receiving Brenetafusp monotherapy was recorded at 52%, while the overall response rate (ORR) improved to 12% at the 160 mcg dose, providing a new treatment option for heavily pretreated melanoma patients, particularly those who failed first-line therapies.
- Combination Therapy Efficacy: Brenetafusp combined with Pembrolizumab demonstrated higher ORR and DCR, further validating its potential in melanoma treatment, especially in patients with PD-1 resistance, where the median OS reached 14.7 months and circulating tumor DNA response rate was 53%.
- Future Research Plans: Immunocore is advancing Brenetafusp in the ongoing Phase 3 PRISM-MEL-301 trial, planning to administer a 160 mcg dose in combination with Nivolumab, while also conducting Phase 1/2 trials for non-small cell lung cancer and ovarian cancer, showcasing the company's commitment to innovation in cancer immunotherapy.
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- Significant Survival Rates: In 66 heavily pretreated patients with advanced melanoma receiving brenetafusp monotherapy, the 6-month overall survival rate reached 87%, indicating the drug's potential to transform treatment options for difficult-to-treat patients.
- Dose Selection Support: Data indicate that the 160 mcg dose exhibited a higher disease control rate of 52%, providing robust support for the ongoing Phase 3 PRISM-MEL-301 trial, which may enhance first-line treatment outcomes.
- Good Tolerability: Brenetafusp demonstrated favorable tolerability both as monotherapy and in combination with pembrolizumab, with common adverse events including low-grade cytokine release syndrome (56%) and rash (44%), instilling confidence in its clinical application.
- Consistent Clinical Benefits: Brenetafusp showed consistent survival rates (median OS of 14.7 months) even in patients with primary PD-1 resistance, highlighting its potential value in refractory patients and suggesting new directions for future treatment strategies.
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- Dose Selection Support: Data indicates that the 160 mcg dose exhibited a higher disease control rate of 52%, providing strong support for the ongoing Phase 3 PRISM-MEL-301 trial aimed at evaluating the efficacy of brenetafusp in combination with nivolumab.
- Good Tolerability: Brenetafusp demonstrated good tolerability both as monotherapy and in combination with pembrolizumab, with common adverse events including low-grade cytokine release syndrome (56%) and rash (44%), indicating a manageable safety profile that supports future clinical applications.
- Efficacy in Refractory Patients: Even in patients with primary PD-1 resistance, the median overall survival with brenetafusp reached 14.7 months, highlighting its potential clinical benefits in difficult-to-treat melanoma patients and possibly changing the treatment landscape in this area.
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