Compugen Reports Third Quarter 2025 Results
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Nov 10 2025
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Should l Buy CGEN?
Source: PRnewswire
Clinical Trials Update: Compugen presented Phase 1 data for COM701 at ESMO 2025, showing promising results in platinum-resistant ovarian cancer, and is currently enrolling patients in the MAIA-ovarian platform trial with interim analysis expected in Q1 2027.
Partnership Developments: AstraZeneca shared positive results for rilvegostomig in NSCLC and bladder cancer at ESMO 2025, highlighting the potential of their Fc-reduced anti-TIGIT antibody format, which may improve efficacy and safety.
Financial Position: Compugen reported a cash position of approximately $86.1 million as of September 30, 2025, with expectations to fund operations into Q3 2027, despite a net loss of about $6.98 million for the third quarter.
Pipeline and Future Prospects: The company is advancing its immuno-oncology pipeline, including GS-0321, an anti-IL-18 binding protein antibody licensed to Gilead, and aims to leverage its AI/ML platform for novel cancer therapies.
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Analyst Views on CGEN
Wall Street analysts forecast CGEN stock price to rise
2 Analyst Rating
2 Buy
0 Hold
0 Sell
Moderate Buy
Current: 2.150
Low
4.00
Averages
4.00
High
4.00
Current: 2.150
Low
4.00
Averages
4.00
High
4.00
About CGEN
Compugen Ltd. is a therapeutic discovery company. The Company focuses on infrastructure to discover drug targets and develop therapeutics. The Company is engaged in the research, development and commercialization of therapeutic and product candidates. The Company's pipeline primarily consists of early and preclinical stage immuno-oncology programs based on drug targets discovered by the Company, primarily immune checkpoint and myeloid protein target candidates. These programs are focused on the development of cancer immunotherapy drugs with potential to harness the immune system to provide treatment solutions in areas of unmet medical needs in various cancer types and patient populations, both as monotherapy and in combination with other drugs. Its pipeline also includes a preclinical stage fusion protein autoimmune product candidate. Its fields of focus are oncology and immunology, with emphasis on its discovery capabilities on immuno-oncology.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
Compugen Reports 2025 Financial Results and Strategic Update
- Cash Flow Extension: Compugen successfully extended its cash runway into 2029 through a non-dilutive monetization agreement with AstraZeneca, enhancing financial stability and ensuring funding for multiple upcoming clinical trials.
- Significant Revenue Growth: The company reported $67.3 million in revenue for Q4 2025, a substantial increase from $1.47 million in Q4 2024, demonstrating significant progress in commercialization, particularly with a $65 million upfront payment from AstraZeneca.
- R&D Expense Optimization: R&D expenses decreased to $22.8 million in 2025 from $24.8 million in 2024, reflecting improved efficiency in clinical trial management while freeing up funds for new projects.
- Net Profit Turnaround: Compugen achieved a net profit of approximately $56.8 million in Q4 2025, a significant improvement from a net loss of $6.1 million in Q4 2024, indicating a marked enhancement in profitability and boosting investor confidence.
See More
Compugen Q4 Earnings Exceed Expectations with Significant Revenue Growth
- Strong Earnings Report: Compugen's Q4 GAAP EPS of $0.60 surpassed expectations by $0.55, indicating a significant improvement in profitability and reflecting the success of its business model.
- Revenue Surge: The company reported revenue of $67.33 million, a staggering 4480.3% year-over-year increase, exceeding market expectations by $53.03 million, demonstrating robust demand for its products and services.
- Healthy Cash Flow: As of December 31, 2025, Compugen had approximately $145.6 million in cash, cash equivalents, short-term bank deposits, and marketable securities, ensuring sufficient funding for its operational plans through 2029, supporting its long-term growth strategy.
- Debt-Free Position: The cash balance includes a $65 million upfront payment from AstraZeneca, and with no debt, Compugen is well-positioned for future investments and expansion, providing a solid financial foundation for growth.
See More
Compugen Set to Announce Q4 Earnings on March 2nd
- Earnings Announcement: Compugen is set to release its Q4 earnings on March 2nd before market open, with a consensus EPS estimate of $0.14, reflecting a substantial year-over-year increase of 300%, indicating a significant improvement in profitability.
- Revenue Surge: Analysts project that Compugen's Q4 revenue will reach $14.3 million, representing an impressive year-over-year growth of 872.8%, which suggests a strong sales momentum in the market that could attract more investor interest.
- Historical Performance: Over the past two years, Compugen has beaten EPS estimates 88% of the time and revenue estimates 38% of the time, enhancing market confidence in its future financial performance due to this consistent track record of exceeding expectations.
- Royalty Deal Impact: Compugen's recent royalty agreement with AstraZeneca has led to a rise in its stock price, further solidifying its market position in the biopharmaceutical sector and potentially supporting future revenue growth.
See More
Compugen to Participate in Upcoming Investor Conferences
- Investor Conference Schedule: Compugen will participate in the Oppenheimer 36th Annual Healthcare Life Sciences Conference on February 26, 2026, in a virtual format featuring fireside chats and one-on-one meetings, which is expected to draw investor interest in its clinical-stage cancer immunotherapy.
- Timing and Location: Following the Oppenheimer event, Compugen will also attend the Leerink Partners 2026 Global Healthcare Conference in Miami, Florida, on March 9, 2026, with the fireside chat scheduled for 8:40 AM ET, further enhancing the company's visibility among investors.
- Technological Platform Advantage: Compugen leverages its AI/ML-powered computational discovery platform, Unigen™, focusing on identifying novel drug targets and biological pathways to advance cancer immunotherapy development, showcasing its technological leadership in the industry.
- Clinical Pipeline Progress: The company has multiple clinical-stage projects, including COM902 and rilvegostomig targeting TIGIT, with the latter being developed by AstraZeneca in Phase 3, indicating Compugen's innovative potential and competitive edge in cancer treatment.
See More
Compugen to Release Q4 and Full Year 2025 Financial Results
- Earnings Release Schedule: Compugen will announce its fourth quarter and full year 2025 financial results on March 2, 2026, before the U.S. markets open, which is expected to provide investors with critical financial data and operational updates.
- Conference Call Details: Management will host a conference call and webcast at 8:30 AM ET, with investors able to join by dialing 1-866-744-5399 in the U.S. or +972-3-918-0644 internationally, ensuring broad investor participation.
- Technology Platform Overview: Compugen utilizes its AI/ML-powered computational discovery platform (Unigen™) to identify novel drug targets and biological pathways, focusing on developing cancer immunotherapies, showcasing its innovative capabilities at the clinical stage.
- Pipeline Summary: The company has multiple Fc-reduced programs targeting TIGIT, including COM902 and rilvegostomig, the latter being developed in Phase 3 by AstraZeneca, indicating Compugen's strategic collaboration potential in cancer treatment.
See More
Compugen Appoints New Independent Director
- New Board Member: Compugen appointed Dr. Michele Holcomb as an independent director effective February 11, 2026, bringing over 30 years of experience in biotech and pharmaceuticals, which is expected to enhance the board's strategic guidance and innovation capabilities.
- Financial Strength Context: Entering 2026, Compugen is in a position of financial strength with multiple potential first-in-class clinical programs and two validating pharma partnerships, and Holcomb's expertise will help convert these opportunities into long-term value.
- Rich Industry Experience: Previously serving as Chief Strategy Officer at Cardinal Health, Holcomb defined strategies and optimized portfolios, and her extensive experience in various executive roles will provide crucial support for Compugen's innovation and growth.
- Strategic Partnership Potential: Holcomb's deep background in biotechnology and insights into the healthcare industry will assist Compugen in identifying and seizing new growth opportunities in a competitive market, driving the company's continued success.
See More
Compugen Reports 2025 Financial Results and Strategic Update
- Cash Flow Extension: Compugen successfully extended its cash runway into 2029 through a non-dilutive monetization agreement with AstraZeneca, enhancing financial stability and ensuring funding for multiple upcoming clinical trials.
- Significant Revenue Growth: The company reported $67.3 million in revenue for Q4 2025, a substantial increase from $1.47 million in Q4 2024, demonstrating significant progress in commercialization, particularly with a $65 million upfront payment from AstraZeneca.
- R&D Expense Optimization: R&D expenses decreased to $22.8 million in 2025 from $24.8 million in 2024, reflecting improved efficiency in clinical trial management while freeing up funds for new projects.
- Net Profit Turnaround: Compugen achieved a net profit of approximately $56.8 million in Q4 2025, a significant improvement from a net loss of $6.1 million in Q4 2024, indicating a marked enhancement in profitability and boosting investor confidence.
See More
Compugen Q4 Earnings Exceed Expectations with Significant Revenue Growth
- Strong Earnings Report: Compugen's Q4 GAAP EPS of $0.60 surpassed expectations by $0.55, indicating a significant improvement in profitability and reflecting the success of its business model.
- Revenue Surge: The company reported revenue of $67.33 million, a staggering 4480.3% year-over-year increase, exceeding market expectations by $53.03 million, demonstrating robust demand for its products and services.
- Healthy Cash Flow: As of December 31, 2025, Compugen had approximately $145.6 million in cash, cash equivalents, short-term bank deposits, and marketable securities, ensuring sufficient funding for its operational plans through 2029, supporting its long-term growth strategy.
- Debt-Free Position: The cash balance includes a $65 million upfront payment from AstraZeneca, and with no debt, Compugen is well-positioned for future investments and expansion, providing a solid financial foundation for growth.
See More
Compugen Set to Announce Q4 Earnings on March 2nd
- Earnings Announcement: Compugen is set to release its Q4 earnings on March 2nd before market open, with a consensus EPS estimate of $0.14, reflecting a substantial year-over-year increase of 300%, indicating a significant improvement in profitability.
- Revenue Surge: Analysts project that Compugen's Q4 revenue will reach $14.3 million, representing an impressive year-over-year growth of 872.8%, which suggests a strong sales momentum in the market that could attract more investor interest.
- Historical Performance: Over the past two years, Compugen has beaten EPS estimates 88% of the time and revenue estimates 38% of the time, enhancing market confidence in its future financial performance due to this consistent track record of exceeding expectations.
- Royalty Deal Impact: Compugen's recent royalty agreement with AstraZeneca has led to a rise in its stock price, further solidifying its market position in the biopharmaceutical sector and potentially supporting future revenue growth.
See More
Compugen to Participate in Upcoming Investor Conferences
- Investor Conference Schedule: Compugen will participate in the Oppenheimer 36th Annual Healthcare Life Sciences Conference on February 26, 2026, in a virtual format featuring fireside chats and one-on-one meetings, which is expected to draw investor interest in its clinical-stage cancer immunotherapy.
- Timing and Location: Following the Oppenheimer event, Compugen will also attend the Leerink Partners 2026 Global Healthcare Conference in Miami, Florida, on March 9, 2026, with the fireside chat scheduled for 8:40 AM ET, further enhancing the company's visibility among investors.
- Technological Platform Advantage: Compugen leverages its AI/ML-powered computational discovery platform, Unigen™, focusing on identifying novel drug targets and biological pathways to advance cancer immunotherapy development, showcasing its technological leadership in the industry.
- Clinical Pipeline Progress: The company has multiple clinical-stage projects, including COM902 and rilvegostomig targeting TIGIT, with the latter being developed by AstraZeneca in Phase 3, indicating Compugen's innovative potential and competitive edge in cancer treatment.
See More
Compugen to Release Q4 and Full Year 2025 Financial Results
- Earnings Release Schedule: Compugen will announce its fourth quarter and full year 2025 financial results on March 2, 2026, before the U.S. markets open, which is expected to provide investors with critical financial data and operational updates.
- Conference Call Details: Management will host a conference call and webcast at 8:30 AM ET, with investors able to join by dialing 1-866-744-5399 in the U.S. or +972-3-918-0644 internationally, ensuring broad investor participation.
- Technology Platform Overview: Compugen utilizes its AI/ML-powered computational discovery platform (Unigen™) to identify novel drug targets and biological pathways, focusing on developing cancer immunotherapies, showcasing its innovative capabilities at the clinical stage.
- Pipeline Summary: The company has multiple Fc-reduced programs targeting TIGIT, including COM902 and rilvegostomig, the latter being developed in Phase 3 by AstraZeneca, indicating Compugen's strategic collaboration potential in cancer treatment.
See More
Compugen Appoints New Independent Director
- New Board Member: Compugen appointed Dr. Michele Holcomb as an independent director effective February 11, 2026, bringing over 30 years of experience in biotech and pharmaceuticals, which is expected to enhance the board's strategic guidance and innovation capabilities.
- Financial Strength Context: Entering 2026, Compugen is in a position of financial strength with multiple potential first-in-class clinical programs and two validating pharma partnerships, and Holcomb's expertise will help convert these opportunities into long-term value.
- Rich Industry Experience: Previously serving as Chief Strategy Officer at Cardinal Health, Holcomb defined strategies and optimized portfolios, and her extensive experience in various executive roles will provide crucial support for Compugen's innovation and growth.
- Strategic Partnership Potential: Holcomb's deep background in biotechnology and insights into the healthcare industry will assist Compugen in identifying and seizing new growth opportunities in a competitive market, driving the company's continued success.
See More
