PRF Technologies Reports Positive Study Results for PRF-110 Compared to Zynrelef
PRF Technologies announced positive results from a preclinical study in domestic pigs directly comparing its lead product candidate, PRF-110, to Zynrelef, an approved extended-release product used as a benchmark in the study. Key Results: PRF-110 and Zynrelef each produced clear reductions in pain-related measures, confirming post-operative analgesic activity for both extended-release local analgesic formulations. Across the overall 72-hour assessment period, PRF-110's analgesic effect was comparable to Zynrelef on the primary efficacy endpoints evaluated in this head-to-head preclinical setting. At later post-operative timepoints, PRF-110 maintained analgesic efficacy comparable to ZYNRELEF, supporting the sustained-release characteristics of PRF-110 following a single administration. PRF-110's safety and local tolerability profile in pigs was consistent with prior preclinical experience, with no unexpected findings observed at the doses tested.