PRF Technologies Reports Positive Study Results for PRF-110 Compared to Zynrelef
Written by Emily J. Thompson, Senior Investment Analyst
Updated: 6 days ago
0mins
PRF Technologies announced positive results from a preclinical study in domestic pigs directly comparing its lead product candidate, PRF-110, to Zynrelef, an approved extended-release product used as a benchmark in the study. Key Results: PRF-110 and Zynrelef each produced clear reductions in pain-related measures, confirming post-operative analgesic activity for both extended-release local analgesic formulations. Across the overall 72-hour assessment period, PRF-110's analgesic effect was comparable to Zynrelef on the primary efficacy endpoints evaluated in this head-to-head preclinical setting. At later post-operative timepoints, PRF-110 maintained analgesic efficacy comparable to ZYNRELEF, supporting the sustained-release characteristics of PRF-110 following a single administration. PRF-110's safety and local tolerability profile in pigs was consistent with prior preclinical experience, with no unexpected findings observed at the doses tested.
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About PRFX
PRF Technologies Ltd is an Israel-based company engaged primarily in pharmaceutical sector. The Company is a producer of speciality pharmaceuticals as well as energy analytics powered by artificial intelligence (AI). The Firm develops reformulated and sustained‑release drug‑delivery platforms that combine proven generic medicines with proprietary extended‑release systems to improve patient outcomes. One of the Company's products is PRF‑110 - a ropivacaine‑based formulation designed to deliver localised, extended postoperative analgesia. The Company also advances OcuRingTD, a bio‑erodible drug‑release ring integrated with intraocular lenses for continuous delivery of medications in cataract surgery.In the energy analytics sector the Company operates DeepSolar platform that provides AI‑powered monitoring, forecasting, and optimisation tools for solar asset performance.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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See More
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- NSAID-Free Formula Advantage: The ropivacaine-only formulation of PRF-110 avoids NSAID use, and its lower cardiac toxicity may offer physicians a safer non-opioid pain relief option, potentially enhancing market acceptance.
- Rigorous Study Design: Conducted in a validated pig incisional pain model using von Frey methodology, the study ensures reliability and effectiveness of results, laying a solid foundation for subsequent clinical trials.
- Broad Market Prospects: With increasing healthcare system demands to reduce opioid reliance, the successful development and approval of PRF-110 could open new growth opportunities for PRF Technologies in the postoperative pain management market, enhancing its competitive edge.
See More
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- Innovative Treatment: OcuRing™-K is a bio-erodible intraocular ring designed to deliver ketorolac through a single intraoperative application, potentially eliminating the need for complex post-surgical eye drop regimens, thereby simplifying patient recovery and improving treatment consistency.
- Addressing Market Needs: Cataract surgery is one of the most commonly performed procedures globally, and PRF Technologies' OcuRing™-K aims to enhance drug delivery consistency and reduce dosing burdens, which could significantly improve patient adherence to post-operative care.
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See More
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