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PLRX Should I Buy

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Intellectia

Should You Buy Pliant Therapeutics Inc (PLRX) Today? Analysis, Price Targets, and 2026 Outlook.

Conclusion
Hold
Latest Price
1.290
1 Day change
9.79%
52 Week Range
1.950
Analysis Updated At
2026/03/27
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Pliant Therapeutics Inc (PLRX) is not a good buy for a beginner investor with a long-term strategy at this time. The stock shows bearish technical indicators, weak financial performance, and lacks strong positive catalysts. While hedge funds are buying, the overall sentiment and data do not support a compelling long-term investment case.

Technical Analysis

The stock is showing bearish technical indicators. The MACD is negative and expanding, RSI is neutral at 33.89, and moving averages are bearish (SMA_200 > SMA_20 > SMA_5). The current price is near the support level of 1.243, but there is no clear upward momentum.

Options Data

Bullish
Open Interest Put-Call Ratio
Bullish
Option Volume Put-Call Ratio

Technical Summary

StrongSellSellNeutralBuyStrongBuydotted line Image
Sell
9
Buy
4

Positive Catalysts

  • Hedge funds are increasing their buying activity, with a 138.46% increase in the last quarter. Management has sufficient cash to fund operations into 2H28, providing operational stability.

Neutral/Negative Catalysts

  • Bearish technical indicators, weak financial performance with significant YoY declines in Net Income (-52.59%) and EPS (-53.66%), and no recent news or congress trading data to act as a catalyst. Analysts have lowered price targets to $3, indicating limited upside potential.

Financial Performance

In Q4 2025, the company reported no revenue growth (0% YoY), a significant drop in Net Income (-52.59% YoY), and a decline in EPS (-53.66% YoY). Gross Margin remained at 0%. Overall, the financial performance is weak.

Growth

Profitability

Efficiency

Analyst Ratings and Price Target Trends

Analysts have lowered price targets from $4 to $3. Canaccord maintains a Hold rating, while Piper Sandler keeps an Overweight rating but acknowledges the stock's challenges and long development timelines for its pipeline.

Wall Street analysts forecast PLRX stock price to rise
4 Analyst Rating
Wall Street analysts forecast PLRX stock price to rise
0 Buy
3 Hold
1 Sell
Hold
Current: 1.175
sliders
Low
2
Averages
3
High
4
Current: 1.175
sliders
Low
2
Averages
3
High
4
Canaccord
Hold
downgrade
$4 -> $3
AI Analysis
2026-03-13
Reason
Canaccord
Price Target
$4 -> $3
AI Analysis
2026-03-13
downgrade
Hold
Reason
Canaccord lowered the firm's price target on Pliant Therapeutics to $3 from $4 and keeps a Hold rating on the shares. The firm said Pliant reported financial results and business highlights for 4Q25 and FY2025. As of December 31, 2025, the company had cash and cash equivalents of $192.4M. Management believes that the cash on hand is sufficient to fund planned operations into 2H28.
Piper Sandler
Overweight
to
NULL
downgrade
$4 -> $3
2026-03-12
Reason
Piper Sandler
Price Target
$4 -> $3
2026-03-12
downgrade
Overweight
to
NULL
Reason
Piper Sandler lowered the firm's price target on Pliant Therapeutics to $3 from $4 and keeps an Overweight rating on the shares. At Q4/FY25 earnings, Pliant provided a thoughtful update to their PLN-101095 program, the firm notes. Specifically, management detailed they have begun an accelerated development plan for PLN-101095 inclusive of beginning initiation activities for an open-label Phase 1b indication expansion trial which has first patient enrollment expected Q2 2026 and interim data 2027. Piper believes 2026 will be an informative year for Pliant as they continue to progress PLN-101095 development based on key Phase 1 data which will be presented at AACR 2026.
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