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PLRX Should I Buy

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Intellectia

Should You Buy Pliant Therapeutics Inc (PLRX) Today? Analysis, Price Targets, and 2026 Outlook.

Conclusion
Hold
Latest Price
1.300
1 Day change
0.78%
52 Week Range
1.950
Analysis Updated At
2026/04/17
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Pliant Therapeutics Inc (PLRX) is not a compelling buy for a beginner investor with a long-term horizon at this time. The stock lacks strong positive catalysts, has weak financial performance, and no significant trading signals or news to suggest immediate upside potential.

Technical Analysis

The MACD is negative and expanding, indicating bearish momentum. RSI is neutral at 48.462, and moving averages are converging, showing no clear trend. The stock is trading near its pivot level of 1.321, with key resistance at 1.365 and support at 1.277.

Options Data

Bullish
Open Interest Put-Call Ratio
Bullish
Option Volume Put-Call Ratio

Technical Summary

StrongSellSellNeutralBuyStrongBuydotted line Image
Sell
7
Buy
2

Positive Catalysts

  • Hedge funds are increasing their buying activity by 138.46%, and the company has sufficient cash to fund operations into 2H28.

Neutral/Negative Catalysts

  • Analysts have lowered price targets to $3, citing weak financial performance and a long timeline for meaningful data from clinical trials. No recent news or congress trading activity to drive sentiment.

Financial Performance

In Q4 2025, revenue remained at $0 with no growth. Net income dropped significantly by -52.59% YoY to -$23.58M, and EPS fell by -53.66% YoY to -$0.38. Gross margin remains at 0%.

Growth

Profitability

Efficiency

Analyst Ratings and Price Target Trends

Analysts have lowered price targets from $4 to $3. Canaccord maintains a Hold rating, while Piper Sandler keeps an Overweight rating but highlights a long development timeline for key programs.

Wall Street analysts forecast PLRX stock price to rise
4 Analyst Rating
Wall Street analysts forecast PLRX stock price to rise
0 Buy
3 Hold
1 Sell
Hold
Current: 1.290
sliders
Low
2
Averages
3
High
4
Current: 1.290
sliders
Low
2
Averages
3
High
4
Canaccord
Hold
downgrade
$4 -> $3
AI Analysis
2026-03-13
Reason
Canaccord
Price Target
$4 -> $3
AI Analysis
2026-03-13
downgrade
Hold
Reason
Canaccord lowered the firm's price target on Pliant Therapeutics to $3 from $4 and keeps a Hold rating on the shares. The firm said Pliant reported financial results and business highlights for 4Q25 and FY2025. As of December 31, 2025, the company had cash and cash equivalents of $192.4M. Management believes that the cash on hand is sufficient to fund planned operations into 2H28.
Piper Sandler
Overweight
to
NULL
downgrade
$4 -> $3
2026-03-12
Reason
Piper Sandler
Price Target
$4 -> $3
2026-03-12
downgrade
Overweight
to
NULL
Reason
Piper Sandler lowered the firm's price target on Pliant Therapeutics to $3 from $4 and keeps an Overweight rating on the shares. At Q4/FY25 earnings, Pliant provided a thoughtful update to their PLN-101095 program, the firm notes. Specifically, management detailed they have begun an accelerated development plan for PLN-101095 inclusive of beginning initiation activities for an open-label Phase 1b indication expansion trial which has first patient enrollment expected Q2 2026 and interim data 2027. Piper believes 2026 will be an informative year for Pliant as they continue to progress PLN-101095 development based on key Phase 1 data which will be presented at AACR 2026.
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