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LYEL Should I Buy

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Intellectia

Should You Buy Lyell Immunopharma Inc (LYEL) Today? Analysis, Price Targets, and 2026 Outlook.

Conclusion
Hold
Latest Price
20.140
1 Day change
2.23%
52 Week Range
45.000
Analysis Updated At
2026/03/20
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Lyell Immunopharma Inc (LYEL) is not a strong buy at this time for a beginner investor with a long-term focus. The technical indicators are neutral to bearish, the financial performance is weak with declining revenue and EPS, and there are no recent positive catalysts or significant trading signals. While analysts have provided optimistic price targets, the lack of recent news or trading sentiment and the poor financial performance suggest holding off on investment for now.

Technical Analysis

The MACD is below 0 and negatively contracting, indicating bearish momentum. RSI is neutral at 35.049, and moving averages are converging, showing no clear trend. The stock is trading near its S1 support level of 19.731, with resistance levels at 23.112 and 26.493.

Options Data

Bullish
Open Interest Put-Call Ratio
Bullish
Option Volume Put-Call Ratio

Technical Summary

StrongSellSellNeutralBuyStrongBuydotted line Image
Sell
6
Buy
5

Positive Catalysts

  • Analysts have raised price targets, with one citing promising clinical data for the company's lead therapy, Ronde-Cel, in the B-cell lymphoma market. The bull case suggests a potential 209% upside.

Neutral/Negative Catalysts

  • The company's financial performance in Q4 2025 shows significant declines in revenue (-45.45% YoY), net income (-26.68% YoY), and EPS (-49.96% YoY). There is no recent news, congress trading data, or significant insider/hedge fund activity to support a bullish sentiment.

Financial Performance

In Q4 2025, revenue dropped to $6,000 (-45.45% YoY), net income fell to -$140.72 million (-26.68% YoY), and EPS declined to -6.86 (-49.96% YoY). Gross margin remained flat at 100%.

Growth

Profitability

Efficiency

Analyst Ratings and Price Target Trends

Analysts are optimistic, with Lucid Capital raising the price target to $39 from $32 and maintaining a Buy rating. Citizens initiated coverage with an Outperform rating and a $34 price target, citing promising clinical data and significant upside potential.

Wall Street analysts forecast LYEL stock price to rise
2 Analyst Rating
Wall Street analysts forecast LYEL stock price to rise
1 Buy
0 Hold
1 Sell
Hold
Current: 19.700
sliders
Low
12
Averages
28.5
High
45
Current: 19.700
sliders
Low
12
Averages
28.5
High
45
Lucid Capital
Christopher Liu
Buy
maintain
$32 -> $39
AI Analysis
2026-03-13
Reason
Lucid Capital
Christopher Liu
Price Target
$32 -> $39
AI Analysis
2026-03-13
maintain
Buy
Reason
Lucid Capital analyst Christopher Liu raised the firm's price target on Lyell Immunopharma to $39 from $32 and keeps a Buy rating on the shares following the fiscal 2025 results. The cites lower estimated dilutive financing this year for the target increase.
Citizens
Outperform
initiated
$34
2026-03-09
Reason
Citizens
Price Target
$34
2026-03-09
initiated
Outperform
Reason
Citizens initiated coverage of Lyell Immunopharma with an Outperform rating and $34 price target. Ronde-Cel, the company's lead dual-targeting CD19/CD20 CAR T-cell therapy, has demonstrated "promising" Phase 1/2 clinical data in the multi-billion-dollar B-cell lymphoma market, the analyst tells investors in a research note. The firm believes Lyell shares represent an attractive investment opportunity with 36% downside in a bear case and 209% upside in a bull case.
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