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ANNX Should I Buy

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Intellectia

Should You Buy Annexon Inc (ANNX) Today? Analysis, Price Targets, and 2026 Outlook.

Conclusion
Hold
Latest Price
6.380
1 Day change
-2.45%
52 Week Range
7.180
Analysis Updated At
2026/04/17
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Annexon Inc (ANNX) is not a strong buy at the moment for a beginner, long-term investor with $50,000-$100,000 available for investment. While there are some positive signals such as insider buying and bullish technical indicators, the company's financial performance is weak, with no revenue growth and declining net income and EPS. Additionally, the options data suggests a bearish sentiment, and there are no strong proprietary trading signals to support an immediate buy decision.

Technical Analysis

The technical indicators for ANNX show a bullish trend with MACD above 0 and expanding positively, bullish moving averages (SMA_5 > SMA_20 > SMA_200), and the RSI at 71.988 in the neutral zone. Key resistance levels are at 6.341 and 6.649, while support levels are at 5.344 and 5.036. However, the stock's candlestick pattern analysis predicts a slight decline in the short term (-0.89% in the next day and -0.01% in the next week).

Options Data

Bullish
Open Interest Put-Call Ratio
Bearish
Option Volume Put-Call Ratio

The options data indicates a bearish sentiment with a high Option Volume Put-Call Ratio of 1.9, suggesting more put activity compared to calls. Implied volatility is high at 292.01, with an IV percentile of 92.4, indicating significant uncertainty in the stock's future price movements.

Technical Summary

StrongSellSellNeutralBuyStrongBuydotted line Image
Sell
4
Buy
10

Positive Catalysts

  • Insider buying by William H. Carson, who purchased 8,000 shares at $6.20 each, reflects confidence in the company. This purchase led to a 6% increase in the stock price, showing positive market sentiment.

Neutral/Negative Catalysts

  • Weak financial performance in 2025/Q4, with no revenue growth, a decline in net income (-0.69% YoY), and a drop in EPS (-9.68% YoY). Additionally, options data suggests bearish sentiment, and there are no recent congress trading data or strong proprietary trading signals to support a buy.

Financial Performance

In 2025/Q4, Annexon Inc reported no revenue growth (0% YoY), a net income decline to -$48.26 million (-0.69% YoY), and a drop in EPS to -0.28 (-9.68% YoY). Gross margin remains at 0%, indicating no profitability.

Growth

Profitability

Efficiency

Analyst Ratings and Price Target Trends

No recent analyst rating or price target changes are available for ANNX. Wall Street sentiment is neutral, with no significant hedge fund or insider trading trends in the last quarter.

Wall Street analysts forecast ANNX stock price to rise
6 Analyst Rating
Wall Street analysts forecast ANNX stock price to rise
6 Buy
0 Hold
0 Sell
Strong Buy
Current: 6.540
sliders
Low
8
Averages
16.4
High
27
Current: 6.540
sliders
Low
8
Averages
16.4
High
27
Chardan
Daniil Gataulin
Buy
initiated
$16
AI Analysis
2025-12-23
Reason
Chardan
Daniil Gataulin
Price Target
$16
AI Analysis
2025-12-23
initiated
Buy
Reason
Chardan analyst Daniil Gataulin initiated coverage of Annexon with a Buy rating and $16 price target. The firm cites the commercial potential of the company's complement C1q inhibitors tanruprubart in Guillain-Barre syndrome and vonaprument in geographic atrophy for the Buy rating. It sees additional upside potential from tanruprubart in Huntington's disease.
Wells Fargo
NULL
to
Overweight
upgrade
$14 -> $27
2025-11-19
Reason
Wells Fargo
Price Target
$14 -> $27
2025-11-19
upgrade
NULL
to
Overweight
Reason
Wells Fargo raised the firm's price target on Annexon to $27 from $14 and keeps an Overweight rating on the shares. The firm is raising its probability of success to 55% from 10% that vonaprument's Phase 3 trial in GA will be positive in the second half of 2026. Wells believes the setup offers a significant, asymmetric risk/reward skew with the potential for VC-like upside in the next 12 months.
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