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ANAB Should I Buy

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Intellectia

Should You Buy AnaptysBio Inc (ANAB) Today? Analysis, Price Targets, and 2026 Outlook.

Conclusion
Buy
Latest Price
63.790
1 Day change
-1.36%
52 Week Range
66.660
Analysis Updated At
2026/03/05
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AnaptysBio Inc (ANAB) is a good buy for a beginner investor with a long-term strategy and $50,000-$100,000 available for investment. Despite recent price declines, the company's strong financial performance, positive analyst sentiment, and upcoming catalysts make it an attractive long-term investment opportunity.

Technical Analysis

The stock shows a bullish trend with moving averages aligned positively (SMA_5 > SMA_20 > SMA_200). The MACD histogram is above zero, indicating positive momentum, though it is contracting. RSI is neutral at 57.288, and the stock is trading near its pivot level of 57.241, with key support at 53.119 and resistance at 61.363.

Options Data

Bullish
Open Interest Put-Call Ratio
Bullish
Option Volume Put-Call Ratio

The low put-call ratios indicate bullish sentiment in the options market, with significantly higher call activity compared to puts.

Technical Summary

StrongSellSellNeutralBuyStrongBuydotted line Image
Sell
3
Buy
9

Positive Catalysts

  • Strong Q4 financial performance with a 151.1% YoY revenue increase and EPS exceeding expectations.

  • Analyst upgrades and increased price targets, with the highest target at $

  • Upcoming spin-off of the biopharma portfolio and Phase 3 development updates for rosnilimab in Q

  • Stock repurchase program reducing outstanding shares by 11.2%.

Neutral/Negative Catalysts

  • Insider selling has increased significantly by 189.75% over the last month.

  • Net income and EPS have declined YoY despite revenue growth.

  • Recent price drop of -5.40% in the regular market and additional declines in pre- and post-market trading.

Financial Performance

In Q4 2025, AnaptysBio reported a 151.1% YoY revenue increase to $108.25 million, showcasing strong top-line growth. However, net income dropped by -327.75% YoY to $49.61 million, and EPS fell by -348.61% YoY to 1.79. The gross margin remained stable at 100%. The company has $311.6 million in cash and investments, ensuring sufficient funding for future operations.

Growth

Profitability

Efficiency

Analyst Ratings and Price Target Trends

Analyst sentiment is highly positive, with multiple firms raising price targets recently. Stifel raised the target to $85, Barclays to $79, and H.C. Wainwright to $66, all maintaining Buy or Overweight ratings. Analysts are optimistic about the company's spin-off plans and its differentiated drug pipeline.

Wall Street analysts forecast ANAB stock price to rise
10 Analyst Rating
Wall Street analysts forecast ANAB stock price to rise
9 Buy
1 Hold
0 Sell
Strong Buy
Current: 64.670
sliders
Low
50
Averages
74.13
High
140
Current: 64.670
sliders
Low
50
Averages
74.13
High
140
Truist
Hold
maintain
$36 -> $50
AI Analysis
2026-03-09
New
Reason
Truist
Price Target
$36 -> $50
AI Analysis
2026-03-09
New
maintain
Hold
Reason
Truist raised the firm's price target on AnaptysBio to $50 from $36 and keeps a Hold rating on the shares. The firm is updating its target to reflect the company's Q4 update that pulled forward the timing of the spin-off to late April, the analyst tells investors in a research note. AnaptysBio Q4 revenue beat was also mostly Jemperli milestone driven, Truist notes, adding however that its hold rating is due to poor pipeline outlook and GSK/Tesaro suit overhang.
Stifel
Alex Thompson
Buy
maintain
$56 -> $85
2026-03-05
Reason
Stifel
Alex Thompson
Price Target
$56 -> $85
2026-03-05
maintain
Buy
Reason
Stifel analyst Alex Thompson raised the firm's price target on AnaptysBio (ANAB) to $85 from $56 and keeps a Buy rating on the shares. Following AnaptysBio's Q4 update, the firm notes that operations are underway for the spin-off of the biopharma portfolio into First Tracks Biotherapeutics (TRAX) in Q2 and that the company expects to give an update on rosnilimab Phase 3 RA development plans in Q2 as well.
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