The chart below shows how SRPT performed 10 days before and after its earnings report, based on data from the past quarters. Typically, SRPT sees a +2.57% change in stock price 10 days leading up to the earnings, and a +5.38% change 10 days following the report. On the earnings day itself, the stock moves by +1.43%. This data can give you a slight idea of what to expect for the next quarter's release.
Positive
Project Moonshot Success: Sarepta achieved all goals laid out in Project Moonshot, including obtaining approval for ELEVIDYS, a transformative therapy for Duchenne patients.
Record Gene Therapy Launch: ELEVIDYS had the most successful launch of a gene therapy in history, with Q4 sales of $384 million, a 112% increase over the previous quarter.
Sustainable Profitability Achieved: Sarepta became sustainably profitable and cash flow positive in 2024, projecting over $16 billion in operating income by 2030.
Projected Revenue Growth: The company expects net product revenue for 2025 to be between $2.9 billion and $3.1 billion, representing a 70% growth over 2024.
PMO Franchise Growth: Sarepta's PMO franchise grew modestly year-over-year, achieving $254 million in Q4, despite the launch of ELEVIDYS.
LGMD Program Advancements: The company is advancing multiple LGMD programs, with plans to submit a BLA for SRP-9003 in 2025 and initiate several other studies.
siRNA Program Collaboration: Sarepta's collaboration with Arrowhead adds a broad platform of siRNA programs, enhancing their gene therapy pipeline.
Therapy's Transformative Potential: The EMBARK study for ELEVIDYS showed statistically significant improvements in patients, supporting the therapy's transformative potential.
Strong Development Pipeline: Sarepta has a strong pipeline with numerous programs in various stages of development across multiple disease areas, including neuromuscular and CNS indications.
Negative
Cost of Sales Surge: The company recorded a significant increase in cost of sales, which rose to approximately $132.3 million in Q4 2024 from $44.2 million in Q4 2023, indicating rising expenses associated with the production of ELEVIDYS.
R&D Expense Increase: R&D expenses increased slightly to $200 million in Q4 2024 from $195.5 million in Q4 2023, primarily due to higher manufacturing costs, suggesting ongoing financial pressure in research and development.
SG&A Expense Increase: SG&A expenses also saw a notable rise, reaching approximately $163.9 million in Q4 2024 compared to $131.7 million in Q4 2023, driven by increased professional services and personnel costs, which could impact profitability.
R&D and SG&A Expense Increase: The company anticipates combined non-GAAP R&D and SG&A expenses to be in the range of $1.2 billion to $1.3 billion for 2025, indicating a significant increase in operational costs that may affect future profitability.
Profitability Challenges Ahead: Despite achieving profitability in 2024, the company faces challenges in maintaining this status due to rising operational costs and the need for continued investment in R&D and commercialization efforts.
Sarepta Therapeutics, Inc. (SRPT) Q4 2024 Earnings Call Transcript
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