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CRDF Should I Buy

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Intellectia

Should You Buy Cardiff Oncology Inc (CRDF) Today? Analysis, Price Targets, and 2026 Outlook.

Conclusion
Hold
Latest Price
1.730
1 Day change
52 Week Range
4.550
Analysis Updated At
2026/03/20
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Cardiff Oncology Inc (CRDF) is not a strong buy at the moment for a beginner, long-term investor with $50,000-$100,000 available. While the company has promising developments in its pipeline, the lack of immediate catalysts, weak technical indicators, and declining financial performance suggest that waiting for further clarity on its clinical trials or financial improvement would be prudent.

Technical Analysis

The MACD is slightly positive but contracting, indicating weak momentum. RSI is neutral at 38.515, and the moving averages are bearish (SMA_200 > SMA_20 > SMA_5). The stock is trading below key pivot levels, with support at 1.775 and resistance at 2.023. Overall, the technical indicators suggest a weak trend.

Options Data

Bullish
Open Interest Put-Call Ratio
Bullish
Option Volume Put-Call Ratio

The low put-call ratios indicate a bullish sentiment in the options market, but the low volume and high implied volatility (221.55) suggest speculative trading rather than strong institutional confidence.

Technical Summary

StrongSellSellNeutralBuyStrongBuydotted line Image
Sell
8
Buy
5

Positive Catalysts

  • Analysts from H.C. Wainwright and Noble Capital see long-term potential, with price targets of $10 and $12, respectively.

  • The company's lead drug candidate, onvansertib, is being developed for aggressive cancer types, which could be a significant breakthrough if successful.

  • Revenue increased by 60.93% YoY in Q4 2025.

Neutral/Negative Catalysts

  • Piper Sandler reduced the price target from $10 to $6, citing delays in drug approval timelines.

  • Net income and EPS have declined significantly YoY, indicating financial strain.

  • No recent news or significant insider/hedge fund activity to support a near-term rally.

Financial Performance

In Q4 2025, revenue increased by 60.93% YoY to $243,000, but net income dropped by -38.75% YoY to -$7.22M, and EPS fell by -50.00% YoY to -0.11. Gross margin remained stable at 100%. The company has cash reserves of $58.3M, sufficient to fund operations into Q1 2027.

Growth

Profitability

Efficiency

Analyst Ratings and Price Target Trends

Analysts are mixed but leaning positive. Piper Sandler lowered the price target to $6, citing delays in drug approval. H.C. Wainwright and Noble Capital maintain Buy/Outperform ratings with price targets of $10 and $12, respectively, based on long-term potential. However, the timeline for clinical trial results and drug approval is extended, reducing near-term catalysts.

Wall Street analysts forecast CRDF stock price to rise
6 Analyst Rating
Wall Street analysts forecast CRDF stock price to rise
6 Buy
0 Hold
0 Sell
Strong Buy
Current: 1.730
sliders
Low
10
Averages
13.67
High
19
Current: 1.730
sliders
Low
10
Averages
13.67
High
19
Piper Sandler
Overweight
to
NULL
downgrade
$10 -> $6
AI Analysis
2026-02-25
Reason
Piper Sandler
Price Target
$10 -> $6
AI Analysis
2026-02-25
downgrade
Overweight
to
NULL
Reason
Piper Sandler lowered the firm's price target on Cardiff Oncology to $6 from $10 and keeps an Overweight rating on the shares. The firm notes Cardiff ended 2025 with cash of $58.3M to fund operations into Q1 2027. Piper is pushing out onvansertib approval to 2030, removing value for other cancers and rolling forward its discount period to mid-2027.
H.C. Wainwright
H.C. Wainwright
Buy
maintain
$10
2026-01-28
Reason
H.C. Wainwright
H.C. Wainwright
Price Target
$10
2026-01-28
maintain
Buy
Reason
H.C. Wainwright says the selloff yesterday in shares of Cardiff Oncology brings an attractive entry point. The firm finds updated CRDF-004 trial results "highly encouraging." It expects a more mature clinical dataset from the CRDF-004 study in the first half of 2026. The market "overreaction provides an attractive entry point," says H.C. Wainwright. The analyst keeps a Buy rating on Cardiff Oncology with a $10 price target.
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