Wall Street Major Indices Close Mostly Lower Amid Middle East Conflict
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Mar 30 2026
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Source: seekingalpha
- Market Performance: Major Wall Street indices closed mostly lower on Monday, with the tech-heavy Nasdaq Composite down 0.7%, the S&P 500 declining by 0.3%, while the Dow Jones managed a slight gain of 0.1%, reflecting investor caution amid ongoing Middle East conflict during the holiday-shortened trading week.
- Viridian Therapeutics Under Pressure: Viridian Therapeutics (VRDN) faced significant pressure in premarket trading after a 32% drop following the release of topline results from its Phase 3 REVEAL-1 trial, which, despite meeting its primary endpoint, left investors underwhelmed due to a 54% proptosis responder rate compared to 18% for placebo, indicating concerns over overall efficacy.
- Boston Scientific Cautious Trading: Boston Scientific (BSX) traded cautiously in premarket activity after a 9% decline on Monday, even though its CHAMPION-AF study for the Watchman FLX device met primary and secondary endpoints; however, investors noted a slightly higher ischemic stroke rate of 3.2% compared to 2% for blood thinners, raising concerns about the device's safety profile.
- M&T Bank Share Buyback: M&T Bank (MTB) saw its stock rise in premarket trading after announcing a new $5 billion share repurchase program, replacing a previous $4 billion plan approved in January 2025, which underscores the company's commitment to enhancing shareholder value while maintaining discretion over the timing and terms of repurchases.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
