Vir Biotechnology Reveals Phase 2 Data at AASLD The Liver Meeting® and in NEJM, Showing High Undetectable HDV RNA Rates and Positive Safety Profile for Tobevibart and Elebsiran Combination
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Nov 09 2025
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Source: Newsfilter
SOLSTICE Trial Results: The SOLSTICE trial showed that 66% of participants with chronic hepatitis delta achieved undetectable HDV RNA after 48 weeks of treatment with the combination of tobevibart and elebsiran, with a favorable safety profile and no severe adverse events reported.
ECLIPSE Program: The ECLIPSE registrational program is underway to further evaluate the combination therapy, with topline data expected in the first quarter of 2027, aiming to address the unmet needs in chronic hepatitis delta treatment.
Significance of Findings: Achieving undetectable HDV RNA is crucial for better outcomes in chronic hepatitis delta patients, and the combination therapy has shown promising results in reducing hepatitis B surface antigen levels and normalizing ALT levels.
Regulatory Recognition: The combination therapy has received Breakthrough Therapy and Fast Track designations from the FDA, as well as Priority Medicines and orphan drug designations from the EMA, highlighting its potential as a significant treatment option.
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Analyst Views on VIR
Wall Street analysts forecast VIR stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for VIR is 17.50 USD with a low forecast of 12.00 USD and a high forecast of 31.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
7 Analyst Rating
7 Buy
0 Hold
0 Sell
Strong Buy
Current: 7.780
Low
12.00
Averages
17.50
High
31.00
Current: 7.780
Low
12.00
Averages
17.50
High
31.00
About VIR
Vir Biotechnology, Inc. is a clinical-stage biopharmaceutical company focused on powering the immune system to transform lives by discovering and developing medicines for serious infectious diseases and cancer. Its clinical-stage portfolio includes infectious disease programs for chronic hepatitis delta and chronic hepatitis B infections and multiple dual-masked T-cell engagers across validated targets in solid tumor indications. It also has a preclinical portfolio of programs across a range of infectious diseases and oncologic malignancies. Tobevibart is an investigational neutralizing monoclonal antibody (mAb) that has been engineered for immune engagement and targets a conserved region on the hepatitis B surface antigen (HBsAg). Elebsiran is an investigational HBV-targeted small interfering RNA (siRNA) that reduces HBsAg. Its pipeline includes VIR-5818, VIR-5500, VIR-5525, and HIV Cure. It also has rights to the PRO-XTEN masking platform for oncology and infectious disease.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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