Veracyte Enzamet Trial Results Show Genomic Test Guides Treatment

Veracyte announced results from the Enzamet trial presented at the 2026 ASCO Annual Meeting. The analysis demonstrates that the Decipher Prostate test identifies which men with metastatic prostate cancer benefit from adding the chemotherapy docetaxel to standard hormonal therapy, known as triplet therapy, and who can safely avoid it, providing the first Level 1B 1 evidence for a genomic test guiding this decision. Results showed: Patients with higher Decipher scores and high-volume disease who received triplet therapy had clinically meaningful better survival compared to those on standard hormonal therapy alone. Patients with lower Decipher scores showed no benefit from adding chemotherapy, suggesting it may be safely avoided. The treatment-by-biomarker interaction was statistically significant, providing Level 1B evidence for the test's predictive value. Patients with higher Decipher scores who received triplet therapy had more aggressive disease features, yet achieved comparable survival to lower-risk patients on doublet therapy, suggesting chemotherapy offset the poor prognostic effects of aggressive disease biology.