Tenax Initiates Global LEVEL-2 Study, Enrollment Expected by 2027
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Dec 17 2025
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Source: Newsfilter
- Trial Design Confirmation: Tenax Therapeutics' LEVEL study underwent a Blinded Sample Size Re-estimation, demonstrating over 90% statistical power to detect a 25-meter change in 6-minute walk distance, which bolsters confidence in the company's drug development in heart failure.
- Enrollment Progress: The LEVEL study is expected to complete enrollment in the first half of 2026, indicating smooth clinical trial progress in cardiopulmonary therapies, allowing timely access to critical data to support further development.
- New Study Initiation: The LEVEL-2 study has been initiated, aiming to enroll approximately 540 patients, with completion expected by the end of 2027, which will provide crucial data to support the market potential of TNX-103.
- Long-term Study Plan: Tenax will also conduct a long-term open-label extension study to ensure participants continue receiving TNX-103 after trial completion, enhancing patient reliance on the company's product.
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Analyst Views on TENX
Wall Street analysts forecast TENX stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for TENX is 25.00 USD with a low forecast of 20.00 USD and a high forecast of 30.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
4 Analyst Rating
4 Buy
0 Hold
0 Sell
Strong Buy
Current: 13.370
Low
20.00
Averages
25.00
High
30.00
Current: 13.370
Low
20.00
Averages
25.00
High
30.00
About TENX
Tenax Therapeutics, Inc. is a Phase 3 development-stage pharmaceutical company. The Company is focused on identifying, developing, and commercializing products that address cardiovascular and pulmonary diseases with high unmet medical needs. The Company's products include TNX-201 (oral enteric-coated imatinib) and TNX-103 (oral levosimendan). The Company is developing dosing and a formulation of imatinib mesylate, a kinase inhibitor for the treatment of pulmonary arterial hypertension (PAH). The Company’s other programs include TNX-101 and TNX-102. Levosimendan is a calcium sensitizer/K-ATP activator developed for intravenous use in hospitalized patients with acutely decompensated heart failure. The Company has completed the Phase II trial of levosimendan in patients with PH and heart failure with preserved ejection fraction (HFpEF).
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
Tenax Therapeutics (TENX) Price Target Raised by 12.22% to 25.76
Price Target Update: The average one-year price target for Tenax Therapeutics (NasdaqCM:TENX) has been revised to $25.76 per share, reflecting a 12.22% increase from the previous estimate of $22.95, with a potential range between $20.20 and $31.50 per share.
Fund Sentiment: There are currently 48 funds reporting positions in Tenax Therapeutics, marking a 20% increase in ownership over the last quarter, with total shares owned by institutions rising by 109.94% to 4,753K shares.
Significant Shareholder Activity: Ikarian Capital and Boothbay Fund Management both increased their holdings by 100%, while VR Adviser raised its stake by 77.48%, indicating strong interest from institutional investors.
Fintel Overview: Fintel provides comprehensive investment research tools, including fundamentals, analyst reports, and ownership data, aimed at individual investors and small hedge funds to enhance their trading strategies.
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Tenax Initiates Global LEVEL-2 Study, Enrollment Expected by 2027
- Trial Design Confirmation: Tenax Therapeutics' LEVEL study underwent a Blinded Sample Size Re-estimation, demonstrating over 90% statistical power to detect a 25-meter change in 6-minute walk distance, which bolsters confidence in the company's drug development in heart failure.
- Enrollment Progress: The LEVEL study is expected to complete enrollment in the first half of 2026, indicating smooth clinical trial progress in cardiopulmonary therapies, allowing timely access to critical data to support further development.
- New Study Initiation: The LEVEL-2 study has been initiated, aiming to enroll approximately 540 patients, with completion expected by the end of 2027, which will provide crucial data to support the market potential of TNX-103.
- Long-term Study Plan: Tenax will also conduct a long-term open-label extension study to ensure participants continue receiving TNX-103 after trial completion, enhancing patient reliance on the company's product.
Continue Reading