Soligenix Reports Clinical Success of Optimized SGX302 Gel for Psoriasis Treatment
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Dec 17 2025
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Source: PRnewswire
- Trial Expansion: Soligenix has enrolled four additional patients in its Phase 2a trial of SGX302 (synthetic hypericin) for mild-to-moderate psoriasis, utilizing an optimized gel formulation over an 18-week treatment period, with all patients well tolerated and no drug-related adverse events reported.
- Efficacy Assessment: Among the three evaluable patients, the average PASI score improved by over 50%, with one patient achieving an “Almost Clear” disease status, indicating that the new formulation shows comparable or improved efficacy relative to the previous ointment formulation.
- Market Potential: With an estimated 60-125 million psoriasis patients globally and a treatment market valued at approximately $15 billion in 2020, projected to reach $40 billion by 2027, the success of SGX302 could present significant market opportunities for the company.
- Future Directions: Soligenix plans to continue advancing SGX302 for psoriasis while preparing for the confirmatory Phase 3 trial of HyBryte™ in early-stage cutaneous T-cell lymphoma, with topline results expected in the second half of 2026.
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Analyst Views on SNGX
Wall Street analysts forecast SNGX stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for SNGX is 10.00 USD with a low forecast of 10.00 USD and a high forecast of 10.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
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Moderate Buy
Current: 1.370
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Current: 1.370
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About SNGX
Soligenix, Inc. is a late-stage biopharmaceutical company, which is focused on developing and commercializing products to treat rare diseases where there is an unmet medical need. The Company’s segments include Specialized Biotherapeutics, and Public Health Solutions. Its Specialized BioTherapeutics business segment is engaged in developing and focused on the commercialization of HyBryte (a proposed name of SGX301), a novel photodynamic therapy (PDT), utilizing topical synthetic hypericin activated with safe visible light for the treatment of cutaneous T-cell lymphoma (CTCL). Its Public Health Solutions segment includes development programs for RiVax, its ricin toxin vaccine candidate and SGX943, its therapeutic candidate for antibiotic-resistant and emerging infectious diseases and its vaccine programs targeting filoviruses (such as Marburg and Ebola) and CiVax, its vaccine candidate for the prevention of COVID-19 (caused by SARS-CoV-2).
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
Soligenix Publishes Positive Phase 2a Results for SGX945 in Behçet's Disease Treatment
- Clinical Trial Results: Soligenix's SGX945 demonstrated significant improvement in 7 out of 8 patients in a Phase 2a trial for Behçet's Disease, indicating potential enduring effects after 4 weeks of treatment, which could enhance patient quality of life.
- Efficacy Comparison: After 4 weeks, the SGX945 group showed a 40% improvement relative to placebo, comparable to the 37% improvement seen with the approved drug apremilast, suggesting SGX945's competitive edge in the market.
- Patient Feedback: Patients reported reduced duration and number of oral ulcers during treatment, with SGX945 showing no treatment-related adverse events, indicating strong tolerability and potential for broader patient adoption.
- Future Development Plans: Soligenix intends to reformulate SGX945 for home-based treatment via subcutaneous injection, aiming to expand its application in innate immune-related inflammatory conditions, thereby enhancing its market competitiveness.
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Soligenix Expands Psoriasis Trial, Revealing Improved Results with New Gel
Trial Results: Soligenix, Inc. announced extended results from its Phase 2a trial of SGX302 (synthetic hypericin) for mild-to-moderate psoriasis, showing improvements in various clinical measures with a new gel formulation that enhances application ease.
Patient Tolerance: The SGX302 gel therapy was well tolerated by all patients, with no drug-related adverse events reported, and one patient achieved a significant improvement in their psoriasis status.
Comparative Outcomes: The results from the gel formulation were comparable to or improved upon those from the previous ointment formulation, indicating effective treatment potential for psoriasis lesions.
Stock Performance: Following the announcement, Soligenix's stock experienced a decline of 21.05%, trading at $1.21.
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