Protara Secures $75 Million Funding to Support TARA-002 and Expand Pipeline Development
Stock Performance: Protara Therapeutics Inc. (TARA) shares fell over 18% to $5.55 in premarket trading following the announcement of a $75 million public offering of 13 million shares at $5.75 each.
Offering Details: The underwriters have a 30-day option to purchase an additional 1.95 million shares, with the offering expected to close around December 8, 2025, subject to customary conditions.
Use of Proceeds: The net proceeds from the offering will support the clinical development of TARA-002, an investigational cell therapy for non-muscle invasive bladder cancer and lymphatic malformations, as well as other clinical initiatives and general corporate purposes.
Current Trials and Designations: TARA-002 is in a Phase 2 trial for pediatric lymphatic malformations and has received Rare Pediatric Disease and Orphan Drug designations, while Protara is also advancing IV Choline Chloride, which has similar designations from the FDA.
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ScinoPharm Secures FDA Approval for Glatiramer Acetate Injection in Multiple Sclerosis
- FDA Approval: ScinoPharm Taiwan (TWSE:1789) received FDA approval for its Glatiramer Acetate Injection for treating adult multiple sclerosis patients, marking the company's first finished drug approval and paving the way for regulatory submissions in Europe and Asia for broader commercialization.
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Protara Doses First Patient in Pivotal THRIVE-3 Trial for IV Choline Chloride
- Trial Initiation: Protara Therapeutics has dosed the first patient in its pivotal THRIVE-3 trial for intravenous Choline Chloride, aiming to become the first FDA-approved treatment for choline deficiency in patients reliant on long-term parenteral support, addressing a significant market gap.
- Patient Enrollment: The study plans to enroll approximately 105 patients to assess the efficacy and safety of low- and high-dose IV Choline Chloride, which is expected to significantly reduce the risks of hepatic injury and neuropsychological impairment faced by nearly 78% of long-term parenteral support patients.
- Regulatory Progress: IV Choline Chloride has received Fast Track and Orphan Drug Designation from the FDA, underscoring its potential in treating this underserved population, with interim analysis results anticipated in the second half of 2026.
- Market Performance: Protara's stock is currently trading at $5.46, reflecting a 6.42% increase from its 52-week low of $2.77, indicating positive market expectations and increased investor confidence in the new therapy.









