Protara Doses First Patient in Pivotal THRIVE-3 Trial for IV Choline Chloride
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Jan 07 2026
0mins
Source: NASDAQ.COM
- Trial Initiation: Protara Therapeutics has dosed the first patient in its pivotal THRIVE-3 trial for intravenous Choline Chloride, aiming to become the first FDA-approved treatment for choline deficiency in patients reliant on long-term parenteral support, addressing a significant market gap.
- Patient Enrollment: The study plans to enroll approximately 105 patients to assess the efficacy and safety of low- and high-dose IV Choline Chloride, which is expected to significantly reduce the risks of hepatic injury and neuropsychological impairment faced by nearly 78% of long-term parenteral support patients.
- Regulatory Progress: IV Choline Chloride has received Fast Track and Orphan Drug Designation from the FDA, underscoring its potential in treating this underserved population, with interim analysis results anticipated in the second half of 2026.
- Market Performance: Protara's stock is currently trading at $5.46, reflecting a 6.42% increase from its 52-week low of $2.77, indicating positive market expectations and increased investor confidence in the new therapy.
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Analyst Views on TARA
Wall Street analysts forecast TARA stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for TARA is 24.83 USD with a low forecast of 21.00 USD and a high forecast of 30.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
6 Analyst Rating
6 Buy
0 Hold
0 Sell
Strong Buy
Current: 7.170
Low
21.00
Averages
24.83
High
30.00
Current: 7.170
Low
21.00
Averages
24.83
High
30.00
About TARA
Protara Therapeutics, Inc. is a clinical-stage biotechnology company, which is engaged in advancing transformative therapies for people with cancer and rare diseases. The Company’s portfolio includes its lead candidate, TARA-002, an investigational cell-based therapy in development for the treatment of non-muscle invasive bladder cancer (NMIBC) and lymphatic malformations (LMs). The Company is evaluating TARA-002 in an ongoing Phase II trial in NMIBC patients with carcinoma in situ (CIS) who are unresponsive or naive to treatment with Bacillus Calmette-Guerin (BCG), as well as a Phase II trial in pediatric patients with LMs. In addition, the Company is developing IV Choline Chloride, an investigational phospholipid substrate replacement for patients on parenteral nutrition who are otherwise unable to meet their choline needs via oral or enteral routes.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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Protara Doses First Patient in Pivotal THRIVE-3 Trial for IV Choline Chloride
- Trial Initiation: Protara Therapeutics has dosed the first patient in its pivotal THRIVE-3 trial for intravenous Choline Chloride, aiming to become the first FDA-approved treatment for choline deficiency in patients reliant on long-term parenteral support, addressing a significant market gap.
- Patient Enrollment: The study plans to enroll approximately 105 patients to assess the efficacy and safety of low- and high-dose IV Choline Chloride, which is expected to significantly reduce the risks of hepatic injury and neuropsychological impairment faced by nearly 78% of long-term parenteral support patients.
- Regulatory Progress: IV Choline Chloride has received Fast Track and Orphan Drug Designation from the FDA, underscoring its potential in treating this underserved population, with interim analysis results anticipated in the second half of 2026.
- Market Performance: Protara's stock is currently trading at $5.46, reflecting a 6.42% increase from its 52-week low of $2.77, indicating positive market expectations and increased investor confidence in the new therapy.
Continue Reading