Piper Sandler Upgrades Esperion to Overweight Due to CV Franchise
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Nov 25 2025
0mins
Source: SeekingAlpha
Piper Sandler Coverage Initiation: Piper Sandler has initiated coverage of Esperion Therapeutics (ESPR) with an overweight rating, highlighting the potential for significant sales growth of its cholesterol-lowering drugs, Nexletol and Nexlizet, with a price target of $9, indicating a potential upside of approximately 184%.
Sales Projections and Market Position: The firm anticipates that peak US sales for the drugs could exceed $650 million, supported by exclusivity agreements and a favorable clinical landscape, including expanded labeling for primary and secondary prevention of cardiovascular events.
Cardiologist Survey Insights: A survey of cardiologists indicated that a significant portion believes the expanded label will enhance the role of Nexletol and Nexlizet in treatment options, with 35% expecting a notably greater role in patient care.
Recent Stock Performance: Following the positive coverage and market developments, Esperion shares experienced a ~16% increase in trading on Tuesday.
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Analyst Views on ESPR
Wall Street analysts forecast ESPR stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for ESPR is 7.94 USD with a low forecast of 1.72 USD and a high forecast of 16.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
5 Analyst Rating
4 Buy
0 Hold
1 Sell
Moderate Buy
Current: 3.550
Low
1.72
Averages
7.94
High
16.00
Current: 3.550
Low
1.72
Averages
7.94
High
16.00
About ESPR
Esperion Therapeutics, Inc. is a commercial stage biopharmaceutical company. The Company is focused on developing and commercializing oral, once-daily, non-statin medicines for patients who are at risk for cardiovascular disease (CVD) and are struggling with elevated low-density lipoprotein cholesterol (LDL-C). Its products include NEXLETOL, NEXLIZET, NILEMDO and NUSTENDI. Its NEXLETOL and NEXLIZET (bempedoic acid and ezetimibe) tablets are oral, once-daily, non-statin medicines to lower the risk of myocardial infarction and coronary revascularization in adults with primary hyperlipidemia. Its NEXLETOL is an ATP Citrate Lyase (ACLY), inhibitor that lowers LDL-C and cardiovascular risk by reducing cholesterol biosynthesis and up-regulating the LDL receptors. Its NUSTENDI contains bempedoic acid and ezetimibe and lowers elevated LDL-C through complementary mechanisms of action by inhibiting cholesterol synthesis in the liver and absorption in the intestine.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
Esperion Therapeutics Reports Strong 2025 Preliminary Results with $400 Million Revenue
- Significant Revenue Growth: Esperion's preliminary total revenue for 2025 reached $400 million to $408 million, reflecting a year-over-year increase of 20% to 23%, indicating strong market demand and product acceptance in the cardiovascular treatment sector.
- Strong Product Sales: The company's U.S. net product sales for NEXLETOL and NEXLIZET are projected to be between $156 million and $160 million, representing a 35% to 38% increase compared to 2024, showcasing expanded physician adoption and reimbursement coverage.
- Enhanced Financial Flexibility: As of year-end 2025, Esperion reported approximately $168 million in cash and cash equivalents, providing financial support for ongoing commercial expansion and pipeline development, ensuring sustainable future growth.
- Long-Term Strategic Planning: Esperion introduced its “Vision 2040” strategy aimed at evolving into a multi-product, innovation-driven global pharmaceutical company focused on cardiometabolic disease prevention and expansion into rare hepatic and renal indications, demonstrating the company's ambitious future development plans.
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Esperion Reports $156-$160 Million in 2025 Sales, Unveils Vision 2040 Strategy
- Significant Sales Growth: Esperion anticipates U.S. net product sales for 2025 to be between $156 million and $160 million, reflecting a 35% to 38% increase compared to 2024, indicating strong performance and demand in the cardiovascular sector.
- Optimistic Revenue Outlook: The company expects total revenue to range from $400 million to $408 million in 2025, representing a 20% to 23% increase from 2024, showcasing success in product portfolio expansion and market penetration.
- Vision Strategy Unveiled: Esperion introduced its Vision 2040 strategy, aiming to evolve into a global leader in cardiovascular disease prevention with a diversified product portfolio and a robust pipeline, targeting at least five blockbuster products by 2040.
- Market Expansion Plans: The company plans to enhance its revenue opportunities in the cardiovascular prevention market by investing in sales and marketing, particularly through the introduction of two triple combination products, which are expected to significantly boost competitive positioning.
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