Pfizer's Braftovi Therapy Improves Colorectal Cancer Patient Survival
Written by Emily J. Thompson, Senior Investment Analyst
Updated: 2 hours ago
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Should l Buy PFE?
Source: seekingalpha
- Clinical Trial Success: Pfizer's Braftovi, in combination with cetuximab and Folfiri, significantly improved progression-free survival in colorectal cancer patients in Cohort 3 of the BREAKWATER trial, achieving a key secondary endpoint that underscores the therapy's clinical significance.
- Survival Rate Improvement: The combination therapy also demonstrated a clinically meaningful benefit in overall survival among newly diagnosed patients with BRAF V600E-mutant metastatic colorectal cancer, reinforcing Braftovi's therapeutic potential in this challenging patient population.
- Safety Profile Consistency: No new safety signals were observed during the trial, and the tolerability of Braftovi combined with cetuximab and Folfiri remained consistent with established safety profiles of the individual treatments, validating the safety of this combination therapy.
- FDA Accelerated Approval: Pfizer plans to submit data from Cohort 3 of the BREAKWATER trial to seek FDA approval for the use of Braftovi in combination with cetuximab and Folfiri, further advancing the therapy's market application and potential impact on patient care.
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Analyst Views on PFE
Wall Street analysts forecast PFE stock price to rise
16 Analyst Rating
5 Buy
11 Hold
0 Sell
Moderate Buy
Current: 27.580
Low
24.00
Averages
28.56
High
35.00
Current: 27.580
Low
24.00
Averages
28.56
High
35.00
About PFE
Pfizer Inc. is a research-based, global biopharmaceutical company. The Company is engaged in the discovery, development, manufacture, marketing, sale and distribution of biopharmaceutical products worldwide. Its Biopharma segment includes the Pfizer U.S. Commercial Division, and the Pfizer International Commercial Division. Its product categories include oncology, primary care and specialty care. Its oncology products include Ibrance, Xtandi, Padcev, Adcetris, Inlyta, Lorbrena, Bosulif, Tukysa, Braftovi, Mektovi, Orgovyx, Elrexfio, Tivdak and Talzenna. Its primary care products include Eliquis, Nurtec ODT/Vydura, Zavzpret, the Prevnar family, Comirnaty, Abrysvo, FSME/IMMUN-TicoVac, Nimenrix, Trumenba, and Paxlovid. Its specialty care products include Xeljanz, Enbrel (outside the United States and Canada), Inflectra, Abrilada, Cibinqo, Litfulo, Eucrisa, Velsipity, the Vyndaqel family, Genotropin, BeneFIX, Xyntha, Somavert, Ngenla, Hympavzi, Sulperazon, Zavicefta, Octagam and others.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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- Efficacy Comparison: The BREAKWATER trial revealed a confirmed objective response rate (ORR) of 60.9% for BRAFTOVI, significantly higher than the 40.0% observed in patients receiving chemotherapy with or without bevacizumab, showcasing its potential in clinical applications.
- Market Performance Analysis: Pfizer's stock is currently priced at $27.75, trading 3.5% below its 20-day simple moving average, indicating short-term weakness, despite a 7.90% increase over the past 12 months.
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- Survival Rate Improvement: The overall survival (OS) also demonstrated clinically meaningful prolongation, further validating the efficacy of BRAFTOVI and potentially offering a new treatment option for previously untreated BRAF V600E-mutant mCRC patients, addressing a significant unmet need.
- Safety Profile: At the time of the PFS analysis, the safety profile of BRAFTOVI was consistent with known components, with no new safety signals identified, suggesting a favorable safety profile that enhances its clinical applicability.
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