Opus Genetics Advances BEST1 Clinical Trial as First Participant Shows Positive Safety Results
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Dec 09 2025
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Source: Newsfilter
- Clinical Trial Progress: Opus Genetics' BEST1 clinical trial (BIRD-1) received a positive recommendation from the Independent Data Monitoring Committee, allowing for the continued recruitment of additional participants, indicating the company's potential in treating inherited retinal diseases.
- Safety Assessment: The first participant showed good safety results after one month, supporting the company's ability to proceed with dosing more participants, thereby enhancing confidence in the treatment's efficacy.
- Market Demand: BEST1-associated retinal diseases affect approximately 9,000 patients in the U.S., and Opus Genetics' research aims to address this substantial unmet medical need, potentially offering hope for vision restoration.
- Technological Platform Advantage: The company leverages its proprietary AAV gene therapy platform to deliver a functional BEST1 gene directly to retinal pigment epithelial cells, showcasing its innovative capabilities and competitive edge in the gene therapy market.
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Analyst Views on IRD
Wall Street analysts forecast IRD stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for IRD is 8.00 USD with a low forecast of 6.00 USD and a high forecast of 9.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
9 Analyst Rating
9 Buy
0 Hold
0 Sell
Strong Buy
Current: 2.500
Low
6.00
Averages
8.00
High
9.00
Current: 2.500
Low
6.00
Averages
8.00
High
9.00
About IRD
Opus Genetics, Inc. is a clinical-stage ophthalmic biotechnology company. The Company is engaged in developing gene therapies for the treatment of inherited retinal diseases (IRDs) and other types of therapies for additional ophthalmic disorders. The Company’s pipeline includes adeno-associated virus (AAV)-based investigational gene therapies that address mutations in genes that cause different forms of bestrophinopathy, Leber congenital amaurosis (LCA) and retinitis pigmentosa. Its pipeline also includes OPGx-BEST1 investigational gene therapy, designed to address mutations in the BEST1 gene, which is associated with retinal degeneration. The pipeline also includes Phentolamine Ophthalmic Solution 0.75%, a non-selective alpha-1 and alpha-2 adrenergic antagonist being investigated to reduce pupil size, and APX3330, a novel small-molecule inhibitor of Ref-1 being investigated to slow the progression of non-proliferative diabetic retinopathy.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
Opus Genetics Insider Cam Gallagher Acquires 164,000 Shares of IRD for $323,693
- Insider Purchase: Cam Gallagher of Opus Genetics acquired 164,000 shares of IRD at $1.97 each on Wednesday, totaling an investment of $323,693, reflecting confidence in the company's future prospects.
- Investment Return: Gallagher's investment is currently up approximately 18.1%, based on today's trading high of $2.33, indicating a positive market response and potential growth outlook for IRD.
- Market Performance: Opus Genetics shares rose about 8.7% on Friday, reflecting optimistic sentiment among investors regarding the company's outlook, potentially driven by Gallagher's purchase.
- CEO Acquisition: Additionally, CEO Dwayne L. Hyzak purchased 3,712 shares of MSC Income Fund at $13.43 each for a total of $49,852, demonstrating ongoing confidence in the fund's performance.
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Opus Genetics Grants 50,000 Stock Options to Attract New Employee
- Equity Incentive Plan: Opus Genetics approved an equity award of 50,000 stock options to a new employee under its 2021 Inducement Plan, aimed at attracting top talent and strengthening its team to drive innovation in gene therapy.
- Option Details: The options have an exercise price equal to the fair market value of the company's common stock on the grant date, vesting over four years with 25% vesting after one year and the remaining 75% in quarterly installments, ensuring long-term employee retention aligned with company goals.
- Compliance Assurance: This equity award complies with Nasdaq Listing Rule 5635(c)(4), ensuring that the company adheres to transparent compliance procedures while attracting talent, thereby enhancing investor confidence.
- Company Background: Opus Genetics focuses on developing gene therapies to restore vision for patients with inherited retinal diseases, with a pipeline of seven AAV-based programs, showcasing the company's strong R&D capabilities and market potential in the biopharmaceutical sector.
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