Neumora Receives Upgrade from RBC Capital Markets Due to Obesity and Parkinson's Drug Potential
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Dec 01 2025
0mins
Should l Buy NMRA?
Source: SeekingAlpha
RBC Capital Markets Upgrade: RBC Capital Markets has upgraded Neumora Therapeutics (NMRA) to outperform, raising its price target to $7 from $4, citing the company's promising pipeline beyond neurology that is not reflected in its current stock price.
NLRP3 Inhibitor Potential: Analyst Brian Abrahams emphasized the potential of NMRA-215, a preclinical NLRP3 inhibitor targeting obesity and Parkinson's disease, noting its promising preclinical signals and lack of major toxicity concerns.
Competitive Landscape: Other companies, such as Ventyx Biosciences and Nodthera Therapeutics, are also developing NLRP3 inhibitors for similar conditions, indicating a competitive environment in this therapeutic area.
Cautious Outlook on Neuropsychiatric Programs: While optimistic about NMRA-215, Abrahams expressed caution regarding Neumora's later-stage neuropsychiatric programs, suggesting that current valuations do not reflect potential successes in these areas.
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Analyst Views on NMRA
Wall Street analysts forecast NMRA stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for NMRA is 9.33 USD with a low forecast of 3.00 USD and a high forecast of 18.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
8 Analyst Rating
5 Buy
2 Hold
1 Sell
Moderate Buy
Current: 2.020
Low
3.00
Averages
9.33
High
18.00
Current: 2.020
Low
3.00
Averages
9.33
High
18.00
About NMRA
Neumora Therapeutics Inc. is a clinical-stage biopharmaceutical company. The Company's therapeutic pipeline consists of seven clinical and preclinical neuroscience programs that target novel mechanisms of action for a broad range of underserved neuropsychiatric disorders and neurodegenerative diseases. Its advanced product candidate, navacaprant (NMRA-140), is a novel once-daily oral kappa opioid receptor (KOR) antagonist that is being developed for the treatment of depressive disorder (MDD). Navacaprant is being investigated in the KOASTAL pivotal Phase 3 program, evaluating navacaprant monotherapy in patients with moderate to severe MDD. The Company's next advanced product candidate is NMRA-511, which is a highly selective, novel antagonist of the vasopressin 1a receptor (V1aR) being developed for the treatment of agitation associated with dementia due to Alzheimer's disease (AD).
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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- Favorable Safety Profile: NMRA-511 demonstrated good tolerability and safety, with treatment-emergent adverse events (TEAEs) typically mild to moderate, and a low discontinuation rate of only 2.5% due to TEAEs, establishing a solid foundation for future clinical applications.
- Clear Next Steps: Neumora plans to launch a multiple ascending dose extension study at higher doses in 2026, develop an extended-release formulation for once-daily dosing, and initiate a Phase 2/3 dose-ranging study, reflecting strong confidence in NMRA-511's long-term development.
- KOASTAL Study Expansion: Neumora also announced plans to increase enrollment in the KOASTAL studies by targeting an additional 25% beyond the original target of 332 participants, with a joint topline data readout for KOASTAL-2 and KOASTAL-3 expected in Q2 2026, further enhancing its research footprint in the depression space.
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- Favorable Safety Profile: The drug exhibited an unmatched effect size in a pre-specified subgroup of patients with elevated anxiety, while also showing a favorable safety and tolerability profile, laying a solid foundation for further development.
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- Positive Market Reaction: Following the announcement, Neumora's shares rose over 10% in premarket trading, reflecting investor optimism about the drug's prospects, despite closing at $1.66 on Friday, down 7.3% from previous levels.
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- Rising Investor Interest: Despite no new updates, Neumora Therapeutics and BioRestorative Therapies saw increases of 16.02% and 6.90% respectively, indicating broad investor interest and optimism in the biotech sector, which may fuel a wave of investment across the industry.
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