Nektar Therapeutics Faces Risks as Madrigal Pharmaceuticals Reports $287.3M in Sales
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Jan 05 2026
0mins
Source: Fool
- Clinical Trial Progress: Nektar Therapeutics' rezpegaldesleukin achieved strong phase 2b data for eczema treatment, indicating potential market opportunities despite fierce competition from established drugs.
- Market Risks: Despite positive results, Nektar has no products on the market and continues to incur net losses, facing the risk of stock price plummeting if late-stage studies fail.
- Madrigal's Sales Performance: Madrigal Pharmaceuticals' Rezdiffra received approval in 2024 and generated $287.3 million in net sales in Q3, with expectations to enter blockbuster territory next year, reflecting strong market demand.
- Industry Comparison: Compared to Nektar, Madrigal has stronger market potential in addressing unmet needs, making it a relatively safer investment choice despite still facing risks.
Trade with 70% Backtested Accuracy
Stop guessing "Should I Buy MDGL?" and start using high-conviction signals backed by rigorous historical data.
Sign up today to access powerful investing tools and make smarter, data-driven decisions.
Analyst Views on MDGL
Wall Street analysts forecast MDGL stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for MDGL is 636.22 USD with a low forecast of 527.00 USD and a high forecast of 900.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
12 Analyst Rating
10 Buy
2 Hold
0 Sell
Strong Buy
Current: 494.690
Low
527.00
Averages
636.22
High
900.00
Current: 494.690
Low
527.00
Averages
636.22
High
900.00
About MDGL
Madrigal Pharmaceuticals, Inc. is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a liver disease with high unmet medical need. The Company’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-b agonist designed to target key underlying causes of MASH. Rezdiffra is the medication approved by the United States Food and Drug Administration (FDA) for the treatment of MASH with moderate to advanced fibrosis (consistent with stages F2 to F3). Rezdiffra is a prescribed medicine used along with diet and exercise to treat adults with nonalcoholic steatohepatitis (NASH) with moderate to advanced liver scarring (fibrosis), but not with cirrhosis of the liver. An ongoing Phase III outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (consistent with stage F4c).
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
AIG Stock Drops 10.05% Following Leadership Transition Announcement
- Leadership Transition: American International Group announced CEO Peter Zaffino's planned retirement by mid-2026, resulting in a 10.05% stock drop this week, reflecting market uncertainty regarding future leadership.
- Analyst Rating Adjustment: Barclays analyst Alex Scott maintains an Equal-Weight rating on AIG while lowering the price target from $88 to $81, indicating a cautious outlook on the company's future performance.
- Market Reaction: Following the leadership transition announcement, investor confidence in AIG waned, leading to a decline in its stock price from $75.43, which negatively impacted overall portfolio performance.
- Industry Impact: This stock drop not only affects AIG's market valuation but may also undermine its competitive position in the insurance sector, especially amid increasing leadership uncertainty.
Continue Reading
U.S. Markets Finished Higher on Friday; Sandisk Saw Notable Gains
- U.S. Stock Market Performance: Stock indexes in the U.S. experienced gains on Friday, with the overall market rising by 0.81%.
- Index Increases: The S&P 500 increased by 0.65%, while the Dow Jones Industrial Average saw a gain of 0.48%.
Continue Reading