Nanobiotix Announces Trading Halt on Euronext Paris
Written by Emily J. Thompson, Senior Investment Analyst
Updated: 45 minutes ago
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Source: Newsfilter
- Trading Halt Announcement: Nanobiotix has requested a trading halt for its ordinary shares on Euronext Paris starting May 21, 2026, at 9:00 a.m. CEST, to confirm allocations to investors and announce the pricing of its global offering.
- Global Offering Details: The trading suspension is part of a broader strategy involving a public offering of American Depositary Shares (ADSs) and an international offering of ordinary shares and pre-funded warrants aimed at qualified investors, enhancing the company's market presence in cancer treatment.
- Resumption of Trading: Trading on Euronext Paris is expected to resume on the same day at approximately 3:30 p.m. Paris time / 9:30 a.m. New York time, reflecting the company's commitment to transparency and efficiency in investor relations.
- Company Overview: Founded in 2003 and headquartered in Paris, Nanobiotix focuses on physics-based therapeutic approaches to improve treatment outcomes for cancer patients, holding over 25 patent families across various applications, including oncology.
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About NBTX
Nanobiotix SA is a France-based nanomedicine company. The Company designs and manufactures nanoparticles that safely enhance the efficacy of radiation therapy in the treatment of cancer. It develops new tools for cancer that utilize a physical mode of action at the cellular level of the cancer cell. The Company's NanoXray technology comprises three products. Local treatment (surgery and radiotherapy) provides potential cure and gives the systemic treatment a better chance to life expectancy. NanoXray products are developed for the efficacy of radiotherapy in the tumor cell. Nanobiotix is a spin-off of the State University of New York (SUNY) at Buffalo.
About the author

Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
- Trading Halt Announcement: Nanobiotix has requested a trading halt for its ordinary shares on Euronext Paris starting May 21, 2026, at 9:00 a.m. CEST, to confirm allocations to investors and announce the pricing of its global offering.
- Global Offering Details: The trading suspension is part of a broader strategy involving a public offering of American Depositary Shares (ADSs) and an international offering of ordinary shares and pre-funded warrants aimed at qualified investors, enhancing the company's market presence in cancer treatment.
- Resumption of Trading: Trading on Euronext Paris is expected to resume on the same day at approximately 3:30 p.m. Paris time / 9:30 a.m. New York time, reflecting the company's commitment to transparency and efficiency in investor relations.
- Company Overview: Founded in 2003 and headquartered in Paris, Nanobiotix focuses on physics-based therapeutic approaches to improve treatment outcomes for cancer patients, holding over 25 patent families across various applications, including oncology.
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- Offering Size: Nanobiotix announces a global follow-on offering of approximately €75 million (about $87 million), aiming to raise funds through American Depositary Shares (ADS) and Ordinary Shares to support its cancer treatment development.
- Market Conditions: The offering will be adjusted based on market demand, with underwriters granted a 30-day option to purchase up to 15% additional ADS, demonstrating the company's flexibility in responding to market reactions.
- Use of Proceeds: It is expected that 50-60% of the proceeds will advance the development of Nanoprimer and other platforms, 10% will support JNJ-1900 (NBTXR3), and 30-40% will be allocated for general corporate purposes, reflecting the company's strategic planning for future growth.
- Lock-Up Arrangement: Company executives and supervisory board members will face a 90-day lock-up period post-pricing of the offering to ensure market stability and prevent stock price volatility, indicating the company's commitment to shareholder interests.
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- Clinical Trial Data Released: Nanobiotix presented initial data on JNJ-1900 (NBTXR3) for inoperable stage III non-small cell lung cancer at the 2026 ESTRO Annual Meeting, revealing an overall response rate of 85.7%, indicating the potential efficacy of this treatment.
- Safety Assessment: The study results suggest that intratumoral injection of JNJ-1900 is feasible and safe for patients, with no disease progression observed among participants, highlighting the therapy's potential for long-term durability and effectiveness.
- Comparison to Current Therapies: The complete response rate for JNJ-1900 stands at 57.1%, significantly higher than the less than 5% complete response rate associated with current standard treatments, underscoring JNJ-1900's potential to improve patient outcomes.
- Future Development Directions: Nanobiotix plans to evaluate JNJ-1900 across various solid tumor indications, in combination with immune checkpoint inhibitors, to further advance the clinical development and commercialization of this promising product.
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- FDA Approval: Nanobiotix (NBTX) announced that the FDA has accepted a protocol amendment for the NANORAY-312 study evaluating JNJ-1900 in locally advanced head and neck squamous cell cancers, marking a significant advancement in the company's oncology research.
- Study Design Changes: The new protocol amendment submitted by Johnson & Johnson eliminates the interim analysis and modifies the final analysis to include fewer events, which is expected to expedite the research timeline and potentially shorten the path to market.
- Product Background: JNJ-1900 (NBTXR3) is an investigational oncology product made of functionalized hafnium oxide nanoparticles administered via a one-time intratumoral injection and activated by radiotherapy, demonstrating potential across multiple solid tumor indications.
- Stock Price Fluctuation: Despite NBTX's stock trading between $3.26 and $41.89 over the past year, it closed at $31.16 on Monday, down 11.28%, reflecting market caution regarding the study's progress.
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- Protocol Amendment: Nanobiotix announced the FDA's acceptance of a protocol amendment for its NANORAY-312 study, eliminating the planned interim analysis and modifying the final analysis to include fewer events, which could accelerate the global registration pathway for JNJ-1900 in head and neck cancer, thereby providing earlier revenue generation opportunities for the company.
- Revenue Potential: Under the licensing agreement, Nanobiotix anticipates receiving hundreds of millions in aggregate payments over the next few years, contingent upon achieving remaining development and regulatory milestones related to JNJ-1900 in head and neck and lung cancers, significantly enhancing the company's financial position and market competitiveness.
- Innovative Mechanism: JNJ-1900 (NBTXR3) is a novel oncology product designed to induce significant tumor cell death through a one-time intratumoral injection activated by radiotherapy, potentially scalable across various solid tumors, further advancing the company's R&D strategy.
- Strategic Collaboration: Nanobiotix's licensing agreement with Janssen Pharmaceutica for the global co-development and commercialization of JNJ-1900 underscores the company's robust collaborative network in oncology, aiming to enhance market penetration through various therapeutic combinations.
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- Preclinical Data Release: Nanobiotix presented preclinical data for its Nanoprimer platform at the American Association for Cancer Research annual meeting, showcasing its potential applications in lipid nanoparticle-delivered recombinant DNA, which could open new avenues in cancer treatment.
- Enhanced Bioavailability: Administering LNP-DNA intravenously in mouse models with Nanoprimer significantly reduced hepatic uptake and toxicity while increasing circulating levels of LNP-DNA, thereby improving drug bioavailability and patient treatment outcomes.
- Broad Application Potential: The positive preclinical results indicate that Nanoprimer has extensive applications in LNP-DNA formulations, RNA delivery, gene therapies, and advanced biologics, potentially transforming existing treatment modalities.
- Positive Market Reaction: NBTX shares closed up 4.10% at $33.79 last Friday, reflecting strong market expectations and increased investor confidence in the company's innovative technology.
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