MediWound Publishes Clinical Data Showing NexoBrid Significantly Reduces Traumatic Tattoos
MediWound announced the peer-reviewed publication of new prospective clinical data showing that NexoBrid substantially reduces embedded particles associated with traumatic tattoos following abrasion and blast injuries. The study is published in the Journal of Burn Care & Research, the official journal of the American Burn Association, under the title "Enzymatic Bromelain-based Debridement with NexoBrid: A New Treatment to Effectively Prevent Traumatic Tattoos After Abrasive Incidents and Explosive Events." The mean pigmented wound area decreased from 37.5% before NexoBrid application to 2.1% afterward, a 92.5% reduction in pigmented wound surface compared with the post-scrubbing baseline, with every patient showing substantial clearance of foreign particles. In abrasive injuries, an average of 96% of visible pigments were removed, while pigment load in explosive injuries was reduced by 84%. Treatment was well tolerated, performed at bedside, and no treatment-related adverse events were reported during the early post-procedure period.
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MediWound Reports NexoBrid Reduces Traumatic Tattoo Risk by 92.5%
- Clinical Data Release: MediWound's new clinical data published in the Journal of Burn Care & Research shows that NexoBrid® effectively prevents traumatic tattoos by significantly reducing embedded particles within 24 hours, achieving over a 90% reduction in pigmented wound area, which opens new possibilities for acute trauma treatment.
- Significant Treatment Effects: In a study involving 15 patients, the application of NexoBrid® reduced the pigmented wound area from 37.5% to 2.1%, with an average of 96% visible pigment removal in friction injuries and 84% in blast injuries, demonstrating its potential in managing complex trauma cases.
- High Safety Profile: The treatment process with NexoBrid® was performed at the bedside, well-tolerated by patients, and no treatment-related adverse events were reported during the early post-procedure period, establishing a solid foundation for its clinical application.
- Future Research Directions: Investigators call for larger controlled studies to confirm the long-term cosmetic effects of NexoBrid® and to explore its combined applications in complex trauma, further advancing the clinical use of this therapy.

MediWound Reports NexoBrid's 92.5% Effectiveness in Preventing Traumatic Tattoos
- Clinical Data Release: MediWound's newly published prospective clinical data demonstrates that NexoBrid effectively prevents traumatic tattoos, with pigmented wound area decreasing from 37.5% to 2.1%, achieving a remarkable 92.5% reduction, significantly enhancing trauma management outcomes.
- Innovative Treatment Method: In a study involving 15 patients, NexoBrid was applied within 24 hours post-injury, successfully removing 96% of visible pigments, indicating its high efficacy in addressing friction and blast injuries, which could potentially transform current trauma care standards.
- Research Context: Conducted at Sheba National Burn Center, this study is the first to evaluate NexoBrid's application in preventing traumatic tattoos, highlighting its selective enzymatic action on damaged skin layers, which holds significant clinical implications.
- Future Research Directions: Despite the small sample size and short follow-up, the investigators call for larger controlled studies to confirm NexoBrid's impact on long-term cosmetic outcomes and to further explore its potential in complex trauma applications.








