Lyra Therapeutics Posts 85% Q2 Loss Drop
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Aug 13 2025
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Source: NASDAQ.COM
Financial Performance: Lyra Therapeutics reported a GAAP EPS loss of $5.51 for Q2 2025, which was less negative than expected, but its revenue of $0.18 million fell short of estimates and decreased significantly from the previous year. The company achieved cost reductions leading to a lower net loss compared to Q2 2024.
Clinical and Regulatory Developments: Positive results from the ENLIGHTEN 2 clinical trial for LYR-210 position the company favorably for future regulatory meetings, although no specific timeline for submission has been provided. The company is preparing for a Type C meeting with the FDA to discuss New Drug Application requirements while continuing to manage costs effectively.
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Analyst Views on LYRA
About LYRA
Lyra Therapeutics, Inc. is a clinical-stage biotechnology company. The Company is focused on the development and commercialization of therapies for the localized treatment of patients with chronic rhinosinusitis (CRS). The Company is developing therapies for CRS, a prevalent inflammatory disease of the paranasal sinuses that leads to debilitating symptoms and significant morbidities. LYR-210, the Company’s lead product, is a bioabsorbable nasal implant designed to be administered in a simple, in-office procedure and is intended to deliver six months of continuous anti-inflammatory drug therapy to the sinonasal passages for the treatment of CRS with a single administration. LYR-210, being evaluated in the ENLIGHTEN Phase III clinical program, is intended for patients with and without nasal polyps. The drug embedded within LYR-210 is mometasone furoate (MF).
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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