Intellia and Iovance Face Major Challenges as Stocks Plummet
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Dec 29 2025
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Source: NASDAQ.COM
- Intellia's Clinical Setback: Intellia Therapeutics faced a clinical hold on its candidate nex-z due to a participant's death, resulting in a 19% stock decline, highlighting significant risks and uncertainties in the gene editing sector.
- Iovance's Revenue Growth: Despite Iovance Biotherapeutics' Amtagvi generating $176.7 million in revenue in the first nine months of 2025, nearly doubling year-over-year, the stock has plummeted 61% due to production complexities and unclear profitability pathways, reflecting market concerns about its future.
- Market Potential Assessment: Intellia's nex-z targets approximately 50,000 hereditary transthyretin amyloidosis patients, while the wild type could affect 200,000 to 500,000, indicating substantial market potential, yet achieving clinical and regulatory milestones remains uncertain.
- Investment Risk Advisory: Although analysts suggest that Intellia and Iovance stocks are undervalued at current levels, the significant clinical and commercial challenges each faces warrant caution for long-term investors, particularly as Intellia's stock may struggle to achieve a 139% rise in the coming year.
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Analyst Views on IOVA
Wall Street analysts forecast IOVA stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for IOVA is 9.50 USD with a low forecast of 1.50 USD and a high forecast of 17.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
8 Analyst Rating
6 Buy
1 Hold
1 Sell
Moderate Buy
Current: 2.630
Low
1.50
Averages
9.50
High
17.00
Current: 2.630
Low
1.50
Averages
9.50
High
17.00
About IOVA
Iovance Biotherapeutics, Inc. is a commercial biotechnology company. It is focused on developing and delivering novel polyclonal tumor infiltrating lymphocyte (TIL) therapies for patients with cancer. Its product, Amtagvi, is a tumor-derived autologous T cell immunotherapy indicated for the treatment of adult patients with unresectable or metastatic melanoma previously treated with a PD-1 blocking antibody, and if BRAF V600 mutation positive, a BRAF inhibitor with or without a MEK inhibitor. It is marketing Proleukin (aldesleukin), an interleukin-2 (IL-2) product used in the Amtagvi treatment regimen and in other applications. Amtagvi and Proleukin are part of a treatment regimen that includes lymphodepletion. Its development pipeline includes multicenter trials of TIL cell therapies in additional treatment settings and indications for solid tumor cancers. It also develops therapies, such as genetically modified TIL cell therapy and cytokines for use in the TIL cell therapy regimen.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
Iovance Biotherapeutics Stock Sentiment and Revenue Outlook
- Retail Sentiment Remains Bullish: Over the past 24 hours, retail sentiment around Iovance (IOVA) stock on Stocktwits has stayed in the ‘bullish’ territory, with message volume at ‘high’ levels, indicating strong investor confidence in the company's future developments.
- Significant Revenue Growth: For the three months ending September, Iovance reported total product revenue of $68 million, including $58 million from Amtagvi sales in the U.S., highlighting the company's robust performance in the tumor immunotherapy market.
- Optimistic 2025 Revenue Outlook: Iovance expects full-year 2025 revenue to range between $250 million and $300 million, marking the first full calendar year of Amtagvi sales, with analysts forecasting an average revenue of $259.45 million, reflecting market anticipation for its products.
- Stock Price Volatility and Acquisition Rumors: Despite an 8% rise in IOVA shares on Monday, the stock has fallen 54% over the past 12 months, with investors expressing concern over management's potential discussions with Merck, which could impact future acquisition opportunities.
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Iovance Biotherapeutics Grants 97,710 Stock Options to Attract New Employees
- Stock Option Grant: On January 15, 2026, Iovance Biotherapeutics approved the grant of a total of 97,710 stock options to 17 new non-executive employees, aimed at attracting and retaining talent, thereby enhancing the company's competitiveness in the tumor immunotherapy sector.
- Exercise Price Setting: Each stock option has an exercise price of $2.22, which matches the closing price of Iovance's common stock on the grant date, a pricing strategy that helps incentivize employees to grow alongside the company and enhances their sense of belonging.
- Vesting Schedule: The stock options will vest over three years, with one-third vesting on the first anniversary of the employee's start date and the remaining shares vesting in quarterly installments over the next two years, ensuring long-term employee commitment aligns with the company's growth.
- Incentive Plan Background: This grant is made under Iovance's inducement plan established in 2021 and amended multiple times, complying with Nasdaq listing rules, reflecting the company's commitment to talent acquisition and its ongoing strategic development in the biotechnology industry.
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