Immuneering Updates Clinical Data on Atebimetinib
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Jun 01 2026
0mins
Immuneering announced updated clinical data from its ongoing Phase 2a trial evaluating atebimetinib in combination with modified gemcitabine/nab-paclitaxel in first-line metastatic pancreatic ductal adenocarcinoma. The data are being presented in an oral session at the 2026 American Society of Clinical Oncology, or ASCO. The presentation showcases data from an expanded cohort totaling 55 first-line pancreatic cancer patients. This open-label, single-arm Phase 2a trial evaluated atebimetinib at 320 mg once daily in combination with mGnP in participants with first-line metastatic pancreatic cancer, irrespective of mutational status. The company reported the following as of the April 24 data cutoff date. In the expanded 55-patient cohort, median overall survival was 17.3 months, compared to 8.5 months median overall survival in the pivotal Phase 3 MPACT study of standard of care gemcitabine/nab-paclitaxel. The median follow-up was 11.6 months. Median progression-free survival was 8.3 months, disease control rate was 82%, and the confirmed overall response rate was 36%. In the original 34-patient cohort with longer follow-up, median overall survival was also observed to be 17.3 months - supporting the consistency of the survival signal across cohorts with different durations of follow-up. Only two categories of Grade 3 or higher treatment-related adverse events occurred in at least 10% of participants, both related to chemotherapy. No Grade 4 adverse events related to atebimetinib and no Grade 5 treatment-related adverse events were reported. Only one participant discontinued atebimetinib while continuing mGnP. The safety profile observed in the trial compared favorably to historical experiences with intensive chemotherapy treatments and combination regimens under development in pancreatic cancer. Additionally, 84% of participants with available data maintained or gained weight at three months, a potentially important indicator of preserved performance status and tolerability in this patient population where cachexia is common and correlated with poorer outcomes.
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Wall Street analysts forecast IMRX stock price to rise
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Current: 4.530
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Current: 4.530
Low
11.00
Averages
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High
20.00
About IMRX
Immuneering Corporation is a late-stage clinical oncology company, with an initial focus on patients with RAS, RAF and other mitogen-activated protein kinase (MAPK)-driven cancers. The Company's lead product candidate, atebimetinib (IMM-1-104), is an investigational, oral, once-daily Deep Cyclic Inhibitor of MEK. The Company is conducting a global randomized pivotal trial, MAPKeeper 301, evaluating atebimetinib in combination with chemotherapy in first-line pancreatic cancer patients. The Company's development pipeline also includes its additional clinical-stage product candidate envometinib (IMM-6-415) and other pre-clinical research programs, including research focused on validated core cancer-signaling pathways outside of the MAPK pathway. The Company's Deep Cyclic Inhibition (DCI) platform is enabled by two key elements: Bioinformatics and 3D Tumor Modeling. Its Deep Cyclic Inhibitors inhibit clinically-validated core signaling pathways, such as the MAPK pathway.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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- Extensive Industry Background: Gengos has a broad background in public offerings, M&A, and corporate strategy, having held senior leadership positions at Amgen, Cyteir Therapeutics, and Athira Pharma, which will provide strong support for Immuneering's future growth.
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- Strategic Development Opportunity: Gengos's addition not only strengthens the company's financial leadership but may also provide enhanced support for future financing and M&A activities, aiding Immuneering's further development in the biopharmaceutical sector.
See More
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- M&A Background: Gengos previously served as CFO at Terns Pharmaceuticals, which was acquired by Merck for $6.7 billion, demonstrating his capability in high-pressure financial management, which will be crucial for supporting Immuneering's clinical projects.
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- Strategic Development: Gengos's extensive experience in biotechnology, particularly in business development and strategic advisory roles, will provide critical support for Immuneering's long-term growth and value creation, helping the company stand out in a competitive market.
See More
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- Trial Launch: Immuneering Corporation has initiated the global MAPKeeper 301 Phase 3 clinical trial to evaluate the efficacy and safety of atebimetinib combined with modified gemcitabine/nab-paclitaxel (mGnP) in metastatic pancreatic cancer patients, marking a significant advancement in cancer treatment.
- Patient Recruitment Progress: The first patient has been dosed in the trial, with topline data on overall survival expected in mid-2028, a critical timeline for assessing the new therapy's effectiveness and potentially transforming the treatment landscape for pancreatic cancer.
- Market Demand Response: With nearly 68,000 new pancreatic cancer cases projected in the U.S. for 2026, atebimetinib, a novel MEK inhibitor, aims to improve patient survival by durably shrinking tumors and enhancing tolerability, addressing the urgent need for new treatment options in this high-mortality cancer.
- Strategic Implications: This trial not only showcases Immuneering's innovative capabilities in oncology drug development but also has the potential to enhance the company's position in the competitive biopharmaceutical market by improving patient quality of life and survival rates.
See More
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- Efficacy Metrics: The trial also reported a median progression-free survival of 8.3 months, a disease control rate of 82%, and an objective response rate of 36%, suggesting that Atebimetinib may provide more durable anti-tumor activity and delay disease progression for patients.
- Safety Profile: The safety profile was manageable, with only two Grade 3 adverse events reported in about 10% of participants, and 84% of patients either maintained or gained weight during treatment, indicating good tolerability and potential for improved quality of life.
- Future Research Plans: The company is actively recruiting for the global, randomized Phase 3 MAPKeeper 301 trial to assess the Atebimetinib and mGnP combination, with the first patient expected to be dosed in mid-2026 and topline data anticipated in mid-2028, demonstrating ongoing commitment to advancing cancer treatment options.
See More
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