Evaxion Releases New Data Demonstrating Vaccine Development Potential
Evaxion A/S announces new data demonstrating the platform's ability to also potentially develop vaccines for glioblastoma. The data, which will be presented at the AACR Annual Meeting in San Diego, California, on April 22, is "another confirmation of how AI-Immunology can be applied across a range of different cancers as well as other diseases," the company stated. "We are excited by these new findings confirming that AI-Immunology is a unique platform for designing vaccines for many different cancer types, combining neoantigens with other types of antigens. This holds great potential for improving vaccine efficacy, and we are looking forward to discussing the data with both scientific stakeholders and potential business partners at the AACR Annual Meeting," says Birgitte Rono, CSO of Evaxion.
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- Financial Performance: Evaxion Biotech reported a Q1 2026 GAAP EPS of -$0.01, indicating challenges in profitability, particularly with a significant drop in financial income compared to the same period last year.
- Decline in Financial Income: The financial income for Q1 2026 was $0.3 million, a stark decrease from $2.4 million in the prior year, primarily due to the remeasurement of derivative liabilities from the January 2025 public offering, reflecting the impact of market volatility on the company.
- Cash Flow Status: As of March 31, 2026, the company's cash and cash equivalents stood at $18.4 million, down from $23.2 million as of December 31, 2025, confirming the company's liquidity runway until the second half of 2027.
- Equity Changes: Total equity amounted to $13.2 million as of March 31, 2026, a decrease from $17.0 million as of December 31, 2025, indicating the impact of the net results from the first quarter on the company's financial health.

- Clinical Trial Success Rate: Evaxion A/S's personalized cancer vaccine EVX-01 achieved an impressive 86% success rate in triggering tumor-specific immune responses during its Phase 2 trial for advanced melanoma, indicating the therapy's efficacy and potential.
- Durable Immune Responses: The two-year analysis confirmed that EVX-01 generated durable immune responses, including robust de novo T-cell activity, which may enhance tumor-killing potential, thereby providing better treatment options for patients.
- AI Platform Application: Evaxion's proprietary AI-Immunology platform played a crucial role in the precise selection of vaccine targets with unprecedented accuracy, with Chief Scientific Officer Bigitte Rønø emphasizing that these findings validate the platform's powerful potential in developing transformational cancer treatments.
- Technology Scalability: Evaxion reported progress in applying its AI-Immunology platform to glioblastoma, with preclinical findings demonstrating the successful design of personalized vaccines targeting glioblastoma, highlighting the technology's scalability beyond melanoma and its significant clinical implications.
- Record Immune Response Rate: The personalized cancer vaccine EVX-01 demonstrates an impressive 86% success rate in triggering tumor-specific immune responses, significantly surpassing other methods, indicating its potential effectiveness in cancer treatment.
- Durable Immune Response Analysis: New data reveals that the vaccine elicits durable immune responses for up to two years post-administration, with 86% of patients generating novel tumor-specific T cells, potentially enhancing the vaccine's tumor-killing capabilities.
- Validation of AI Predictive Power: The study shows a positive correlation between AI prediction scores for vaccine targets and the magnitude of immune responses, further validating the effectiveness of the AI-Immunology™ platform in target selection, which may drive innovation in future cancer therapies.
- Clinical Trial Progress: The phase 2 trial of EVX-01 in combination with KEYTRUDA® has achieved a 75% objective response rate, with three-year clinical data expected to be presented in the second half of 2026, showcasing the vaccine's promising application in treating advanced melanoma patients.
- Annual Report Approval: Evaxion A/S held its Annual General Meeting on April 16, 2026, where the 2025 Annual Report was approved, indicating the company's ongoing commitment to financial transparency and governance, thereby enhancing investor confidence.
- Board Member Elections: During the meeting, Marianne Søgaard, Lars Holtug, Lars Aage Staal Wegner, and Roberto Prego Pineda were re-elected to the Board, while Jens Bitsch Nørhave was newly elected, ensuring continuity and expertise in corporate governance.
- Technological Platform Advantage: Evaxion leverages its proprietary AI-Immunology™ platform to focus on developing innovative vaccine candidates for cancer and infectious diseases, showcasing its leading position in the biotech field and potentially laying the groundwork for future market expansion.
- Clinical Pipeline Development: The company currently has a pipeline of personalized and off-the-shelf cancer vaccine candidates as well as prophylactic vaccine candidates, aimed at addressing high unmet medical needs, reflecting its strategic goal of improving patient lives through innovative treatment options.
- Strategic Collaboration Progress: Evaxion A/S's licensing agreement with Merck for the EVX-B3 vaccine candidate marks a significant milestone as the first infectious disease vaccine identified through an AI discovery platform, showcasing the technology's market validation and future potential.
- Improved Financial Position: In 2025, Evaxion achieved a cash inflow of $32 million, with a net loss of $7.7 million, reflecting an improvement from the previous year, and ended with a cash position of $23 million, providing a solid foundation for future R&D and market expansion.
- R&D Pipeline Breakthroughs: The company made significant advancements in its R&D pipeline, with strong Phase II clinical data for EVX-01 in melanoma and the development of the new EVX-04 leukemia vaccine candidate, indicating promising market opportunities ahead.
- Future Outlook: Management anticipates submitting a regulatory application for EVX-04 in 2026, along with updates on biomarker and immunogenicity data for EVX-01, demonstrating ongoing investment in key assets and a keen awareness of market demands.








