Company Raises 2026 Operating Cash Expense Guidance to $165 Million
Written by Emily J. Thompson, Senior Investment Analyst
Updated: May 13 2026
0mins
Based upon the company's current forecast for the overall timing of the ALPHA3 program, it is modestly increasing its guidance for operating cash expense in 2026 from approximately $150M to $165M. GAAP operating expenses are also expected to modestly increase from approximately $210M to $225M, including estimated non-cash stock-based compensation expense of approximately $35M. These estimates exclude any impact from potential business development activities.
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Analyst Views on ALLO
Wall Street analysts forecast ALLO stock price to rise
11 Analyst Rating
10 Buy
0 Hold
1 Sell
Strong Buy
Current: 2.250
Low
5.00
Averages
8.50
High
14.00
Current: 2.250
Low
5.00
Averages
8.50
High
14.00
About ALLO
Allogene Therapeutics, Inc. is a clinical-stage immuno-oncology company. The Company is focused on development of genetically engineered allogeneic T cell product candidates for the treatment of cancer and autoimmune diseases. It is focused on three core programs: Large B-Cell Lymphoma (LBCL), Autoimmune Disease (AID), and Renal Cell Carcinoma (RCC). It is developing a pipeline of multiple allogeneic chimeric antigen receptor (CAR) T cell product candidates utilizing protein engineering, gene editing, gene insertion and advanced proprietary T cell manufacturing technologies. Its product candidate, cemacabtagene ansegedleucel, referred to as cema-cel, is an engineered allogeneic CAR T cell product candidate that targets CD19, a protein expressed on the cell surface of B cells and a validated target for B cell driven hematological malignancies. It is focused on developing cema-cel for LBCL. Its pipeline also includes ALLO-316 and ALLO-329.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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- New CEO Appointment: Zachary Roberts will assume the CEO role on July 1, currently serving as executive vice president of research and development and chief medical officer, which is expected to bring a new strategic direction and management style.
- Financial Outlook Update: Allogene outlines a cash runway extending into Q1 2029 while raising its 2026 operating cash expense guidance to approximately $165 million, reflecting confidence in the company's future financial health.
- Performance Results: Allogene reported a GAAP EPS of -$0.18, beating expectations by $0.01, indicating an improvement in financial performance despite still being in a loss position.
See More
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- Leadership Transition: Dr. David Chang will step down as CEO on June 30, 2026, after eight years of outstanding leadership that established Allogene as a leader in its field, and he will continue to serve on the Board of Directors.
- New CEO Appointment: Dr. Zachary Roberts will take over as CEO effective July 1, 2026, and join the Board; since January 2023, he has reshaped the company's clinical development strategy, driving advances across key projects.
- Clinical Trial Progress: Under Roberts' leadership, Allogene's ALPHA3 trial for first-line large B-cell lymphoma has reported positive interim results, showcasing the company's potential to expand into new disease areas and solidifying its market position.
- Technological Innovation and Market Positioning: During Chang's tenure, the development of the Dagger® technology platform addressed lymphodepletion challenges, enhancing the company's competitiveness in cell therapy, with Chang continuing to provide strategic guidance moving forward.
See More
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- Improved Financial Position: As of March 31, the company had $266.9 million in cash and cash equivalents, and in April, it raised approximately $200.4 million through a public offering, extending its cash runway into Q1 2029, thereby enhancing financial flexibility for R&D.
- Increased Expense Guidance: The forecast for operating cash expenses in 2026 has been raised from approximately $150 million to $165 million, with GAAP operating expenses expected to rise from $210 million to $225 million, reflecting confidence in future R&D investments while potentially impacting short-term financial performance.
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See More
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- Expense Structure: General and administrative expenses totaled $14.1 million in Q1, including $5.6 million in non-cash stock-based compensation, reflecting the company's ongoing investment in talent attraction and retention, which may impact future profitability.
- Cash Position: As of March 31, 2026, the company had $266.9 million in cash, cash equivalents, and investments, ensuring sufficient operational funding for the coming months to support its R&D and market expansion plans.
- Stock Offering Plan: Allogene Therapeutics announced a $175 million stock offering at $2 per share, a move that will provide additional funding to help the company remain competitive in the fast-paced biopharmaceutical market.
See More
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- Analyst Estimate Revisions: In the last three months, Allogene's EPS estimates have seen two upward revisions with no downward adjustments, suggesting increased market confidence in the company's future profitability, which could positively impact its stock price.
- Stock Offering Announcement: Allogene Therapeutics has announced a $175 million stock offering at $2 per share, which not only provides funding to support its R&D efforts but may also affect its shareholder structure and market performance.
See More
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- Technology Expansion: The company plans to extend its Dagger® technology into autoimmune diseases, utilizing a gene-edited dual-targeting CAR T approach aimed at reducing the need for chemotherapy-based lymphodepletion, thereby enhancing treatment durability and safety.
- Future Outlook: Allogene's CAR T therapy aims to enhance accessibility through on-demand availability, safety, and simplicity, potentially transforming the treatment landscape for cancer and autoimmune diseases in the future.
- Industry Leadership: Allogene is positioned as a leader in the evolution of autologous cell therapies, leveraging extensive experience in hematologic and solid tumors to address the growing patient demand and drive advancements in biologic manufacturing scale.
See More
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- Executive Transition: Allogene Therapeutics announced that CEO David Chang will step down on June 30 after eight years, remaining on the board, indicating a significant leadership change within the company.
- New CEO Appointment: Zachary Roberts will assume the CEO role on July 1, currently serving as executive vice president of research and development and chief medical officer, which is expected to bring a new strategic direction and management style.
- Financial Outlook Update: Allogene outlines a cash runway extending into Q1 2029 while raising its 2026 operating cash expense guidance to approximately $165 million, reflecting confidence in the company's future financial health.
- Performance Results: Allogene reported a GAAP EPS of -$0.18, beating expectations by $0.01, indicating an improvement in financial performance despite still being in a loss position.
See More
Leadership Transition at Allogene Therapeutics
- Leadership Transition: Dr. David Chang will step down as CEO on June 30, 2026, after eight years of outstanding leadership that established Allogene as a leader in its field, and he will continue to serve on the Board of Directors.
- New CEO Appointment: Dr. Zachary Roberts will take over as CEO effective July 1, 2026, and join the Board; since January 2023, he has reshaped the company's clinical development strategy, driving advances across key projects.
- Clinical Trial Progress: Under Roberts' leadership, Allogene's ALPHA3 trial for first-line large B-cell lymphoma has reported positive interim results, showcasing the company's potential to expand into new disease areas and solidifying its market position.
- Technological Innovation and Market Positioning: During Chang's tenure, the development of the Dagger® technology platform addressed lymphodepletion challenges, enhancing the company's competitiveness in cell therapy, with Chang continuing to provide strategic guidance moving forward.
See More
Allogene Therapeutics Q1 2026 Earnings Call Insights
- Clinical Trial Progress: In a 24-patient analysis, cema-cel achieved a 58.3% MRD clearance rate compared to 16.7% in the observation arm, representing a significant 41.6% absolute difference, indicating a clear therapeutic advantage that could drive future clinical applications.
- Improved Financial Position: As of March 31, the company had $266.9 million in cash and cash equivalents, and in April, it raised approximately $200.4 million through a public offering, extending its cash runway into Q1 2029, thereby enhancing financial flexibility for R&D.
- Increased Expense Guidance: The forecast for operating cash expenses in 2026 has been raised from approximately $150 million to $165 million, with GAAP operating expenses expected to rise from $210 million to $225 million, reflecting confidence in future R&D investments while potentially impacting short-term financial performance.
- Safety and Tolerability: Management emphasized that no CRS, ICANS, or treatment-related hospitalizations were observed in ALLO-329 treatments, indicating feasibility in outpatient settings, which may attract more patients to participate in clinical trials and enhance market competitiveness.
See More
Allogene Therapeutics Q1 Earnings Beat Expectations
- Earnings Performance: Allogene Therapeutics reported a Q1 2026 GAAP EPS of -$0.18, beating expectations by $0.01, indicating some improvement in financial management despite ongoing losses.
- Expense Structure: General and administrative expenses totaled $14.1 million in Q1, including $5.6 million in non-cash stock-based compensation, reflecting the company's ongoing investment in talent attraction and retention, which may impact future profitability.
- Cash Position: As of March 31, 2026, the company had $266.9 million in cash, cash equivalents, and investments, ensuring sufficient operational funding for the coming months to support its R&D and market expansion plans.
- Stock Offering Plan: Allogene Therapeutics announced a $175 million stock offering at $2 per share, a move that will provide additional funding to help the company remain competitive in the fast-paced biopharmaceutical market.
See More
Allogene Therapeutics Announces $175 Million Stock Offering
- Earnings Announcement: Allogene Therapeutics is set to release its Q1 earnings on May 13th after market close, with consensus EPS estimate at -$0.18 and revenue at $1.82 million, and exceeding these estimates could bolster market confidence.
- Historical Performance: Over the past year, Allogene has beaten EPS and revenue estimates 50% of the time, indicating a certain level of competency in managing market expectations, and the upcoming earnings report will significantly influence investor sentiment regarding future growth.
- Analyst Estimate Revisions: In the last three months, Allogene's EPS estimates have seen two upward revisions with no downward adjustments, suggesting increased market confidence in the company's future profitability, which could positively impact its stock price.
- Stock Offering Announcement: Allogene Therapeutics has announced a $175 million stock offering at $2 per share, which not only provides funding to support its R&D efforts but may also affect its shareholder structure and market performance.
See More
Allogene Showcases CAR T Therapy Potential at AACR Meeting
- Preclinical Evaluation: Allogene presented its preclinical evaluation of BCMA/CD70 dual-targeting CAR T cells for high-risk multiple myeloma at the AACR meeting, indicating potential new treatment options for patients in cancer therapy.
- Technology Expansion: The company plans to extend its Dagger® technology into autoimmune diseases, utilizing a gene-edited dual-targeting CAR T approach aimed at reducing the need for chemotherapy-based lymphodepletion, thereby enhancing treatment durability and safety.
- Future Outlook: Allogene's CAR T therapy aims to enhance accessibility through on-demand availability, safety, and simplicity, potentially transforming the treatment landscape for cancer and autoimmune diseases in the future.
- Industry Leadership: Allogene is positioned as a leader in the evolution of autologous cell therapies, leveraging extensive experience in hematologic and solid tumors to address the growing patient demand and drive advancements in biologic manufacturing scale.
See More
