AngioDynamics Announces Two-Year Results for NanoKnife System
AngioDynamics announced two-year results from the PRESERVE pivotal trial demonstrating durable oncologic control and a sustained safety profile for the NanoKnife System in the focal ablation of intermediate-risk prostate cancer. The data will be discussed by Izak Faiena, M.D., of Columbia University at the 2026 American Urological Association Annual Meeting on Sunday, May 17 in Washington, D.C. The PRESERVE trial is a prospective, single-arm pivotal IDE study evaluating focal irreversible electroporation using the NanoKnife System in 121 patients with Gleason Grade Group 2-3 intermediate-risk prostate cancer, conducted across 17 U.S. clinical centers in collaboration with the Society of Urologic Oncology Clinical Trials Consortium. Primary 12-month results, published in European Urology in July 2025, demonstrated an 80% freedom-from-treatment-failure rate among protocol-biopsied patients. At 24 months, the updated findings confirm durability of outcomes: 94.4% of analysis-eligible patients (68 of 72) completed the 24-month assessment, reflecting strong cohort retention; No new treatment failures were identified among patients with available follow-up at 24 months; One patient (1.5%) underwent a clinically indicated biopsy, which was negative for any cancer; 97% of patients (66 of 68) had a PSA at 24 months below their baseline value; No new device- or procedure-related adverse events were reported between the 12- and 24-month assessments. The 24-month PRESERVE data complement an international long-term evidence base for focal IRE, including median five-year outcomes from a 2023 international multi-institutional cohort demonstrating sustained oncologic control and preservation of functional outcomes.
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- Significant Revenue Growth: AngioDynamics reported an 8.9% increase in total revenue to $78.4 million, with the Med Tech segment achieving $37.3 million in revenue, reflecting a robust 19% growth that underscores the company's strong performance and rising market demand.
- Auryon Platform's Continued Strength: The Auryon platform achieved its 19th consecutive quarter of double-digit year-over-year growth, generating $16.3 million in revenue, indicating its competitive position and technological superiority, which are expected to further drive the company's future growth.
- Optimistic Financial Outlook: The company raised its full-year revenue guidance to $313.5 million to $315.5 million, while also increasing adjusted EBITDA guidance to $10 million to $12 million, reflecting management's confidence in future performance.
- Gross Margin Decline Challenges: Despite revenue growth, gross margin decreased by 110 basis points year-over-year, primarily due to tariffs and inflation, with tariff expenses expected to range between $4 million and $6 million for fiscal year 2026, potentially impacting the company's profitability.
- Significant Revenue Growth: AngioDynamics reported Q3 revenue of $78.4 million, an 8.9% increase year-over-year, surpassing analyst estimates of $76.766 million, which enhances market confidence in the company's performance.
- Strong Med Tech Performance: The Med Tech segment generated $37.3 million in revenue, up 19% and accounting for 48% of total revenue, reflecting a continued shift in business mix that is expected to drive future profitability and market share growth.
- Auryon Momentum: Auryon achieved its 19th consecutive quarter of double-digit year-over-year growth, supported by expansion into the hospital market and CE Mark approval, indicating strengthening competitive positioning in the medical device sector.
- Optimistic Outlook: The company raised its FY2026 net sales guidance to $313.5 million to $315.5 million and adjusted EBITDA guidance to $10 million to $12 million, demonstrating management's confidence in future performance and positive market expectations.
- Loss Report: AngioDynamics reported a GAAP net loss of $8.1 million in Q3, translating to a loss per share of $0.19, which is a significant increase from last year's loss of $4.4 million or $0.11 per share, indicating worsening financial health.
- Adjusted Financials: On a pro forma basis, the net loss was $13.1 million or $0.31 per share, compared to a loss of $9.9 million or $0.24 per share last year, reflecting ongoing operational challenges faced by the company.
- Sales Growth: The company achieved net sales of $78.4 million in Q3, an 8.9% increase year-over-year, with Med Tech sales rising to $37.3 million, a 19.0% increase from $31.3 million last year, demonstrating strong market demand.
- Revised Outlook: For fiscal 2026, the adjusted loss per share is now expected to be in the range of $0.30 to $0.23, revised from a previous guidance of $0.33 to $0.23, while adjusted EBITDA expectations have been raised to $10.0 to $12.0 million, indicating cautious optimism about future performance.
- Performance Highlights: AngioDynamics reported net sales of $78.4 million for Q3 FY 2026, an 8.9% year-over-year increase, with the Med Tech segment achieving $37.3 million in sales, reflecting a robust 19.0% growth that underscores the company's strong position in the medical technology sector.
- Adjusted EBITDA: The company recorded an adjusted EBITDA of $1.8 million in Q3, up 38.5% from $1.3 million in the prior year, indicating ongoing improvements in operational efficiency and cost management, which bolster confidence in future profitability.
- Cash Flow Status: As of February 28, 2026, AngioDynamics maintained a cash balance of $37.8 million and a debt-free status, demonstrating strong financial management and providing ample resources for future investments and expansion.
- Future Outlook: The company raised its guidance for FY 2026, now expecting net sales between $313.5 million and $315.5 million and adjusted EBITDA of $10 million to $12 million, reflecting management's confidence in sustained growth moving forward.
- Earnings Beat: AngioDynamics reported a Q3 non-GAAP EPS of -$0.07, beating expectations by $0.04, indicating improved profitability and boosting market confidence in future performance.
- Revenue Growth: The company achieved revenue of $78.42 million in Q3, an 8.9% year-over-year increase that surpassed market expectations by $1.65 million, demonstrating strong demand for its products, particularly in the Med Tech sector.
- Strong Med Tech Sales: Med Tech net sales reached $37.3 million, a 19% increase from $31.3 million in the prior-year period, showcasing significant growth in market share and competitiveness in this segment.
- Guidance Upgrade for FY 2026: AngioDynamics raised its FY 2026 net sales guidance to $314 million, up from the previous range of $312 million to $314 million, reflecting a positive outlook for future growth.
- Earnings Preview: Major earnings reports expected on Thursday include Acuity (AYI), Lindsay Corporation (LNN), and AngioDynamics (ANGO), all of which hold significant positions in their respective industries, and their results will impact market sentiment.
- Investor Focus: Investors will closely monitor these earnings to assess company performance and future outlook, particularly in the current economic climate where corporate profitability and growth potential are under scrutiny.
- Industry Impact: As a leader in the lighting sector, Acuity's earnings will signal trends in construction and infrastructure investment, while the performance of Lindsay and AngioDynamics may influence investor confidence in the agriculture and medical device sectors.
- Earnings Season: As the earnings season progresses, market expectations and reactions to company performances will directly affect stock market volatility, prompting investors to pay attention to upcoming reports to adjust their investment strategies.









