Amphista Unveils AMX-883, Paving New Treatment Path for Acute Myeloid Leukaemia
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Dec 08 2025
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Source: Globenewswire
- Significant Treatment Potential: AMX-883 demonstrates potent BRD9 degradation as a monotherapy, effectively blocking patient-derived tumor growth and outperforming existing treatments like venetoclax, indicating a new option for acute myeloid leukaemia (AML).
- Combination Therapy Advantage: When used in conjunction with venetoclax, AMX-883 significantly enhances anti-tumor efficacy and effectively blocks tumor growth at therapeutically relevant concentrations, showcasing its synergistic effects in AML treatment.
- Resistance Prevention: AMX-883 effectively prevents the emergence of resistance in venetoclax-resistant cell lines by downregulating key resistance markers, indicating its potential to extend treatment durability.
- Clinical Trial Plans: Based on the new data, Amphista plans to initiate clinical trials for AMX-883 in H2 2026, marking a significant advancement towards clinical development and potentially offering new hope for AML patients.
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Analyst Views on AMPH
Wall Street analysts forecast AMPH stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for AMPH is 30.60 USD with a low forecast of 25.00 USD and a high forecast of 34.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
5 Analyst Rating
2 Buy
3 Hold
0 Sell
Moderate Buy
Current: 26.150
Low
25.00
Averages
30.60
High
34.00
Current: 26.150
Low
25.00
Averages
30.60
High
34.00
About AMPH
Amphastar Pharmaceuticals, Inc. is a biopharmaceutical company that focuses primarily on developing, manufacturing, marketing, and selling generic and proprietary injectable, inhalation, and intranasal products. Additionally, it sells insulin API products. Most of its finished products are used in hospital or urgent care clinical settings and are primarily contracted and distributed through group purchasing organizations and drug wholesalers. The Company manufactures and sells over 25 products, such as BAQSIMI (glucagon) nasal powder 3mg, Primatene MIST, Glucagon for Injection Emergency Kit, Enoxaparin, Naloxone and Other Marketed Products, including Cortrosyn (cosyntropin for injection), Amphadase, Epinephrine injection, Lidocaine jelly, Lidocaine topical solution, Phytonadione injection, and others. The Company manufactures and sells two API products, Recombinant Human Insulin (RHI API) and porcine insulin API, for the injectable insulin market.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
Amphastar's Floyd Petersen Sells 16,679 Shares for $441,836
- Executive Transaction: Floyd Petersen of Amphastar Pharmaceuticals exercised 16,679 stock options and immediately sold all shares for approximately $441,836, indicating a potential lack of confidence in the stock's future performance.
- Ownership Change: Following the sale, Petersen retains 75,531 shares valued at around $2 million, reflecting a 4% reduction in his holdings since May 2024, which may suggest a cautious outlook on market conditions.
- Market Performance: On the transaction date, Amphastar's stock had declined by 42% over the year, contrasting sharply with the S&P 500's 14% total return, highlighting the company's relative underperformance in the market.
- Share Buyback Program: Since 2016, Amphastar has repurchased over 14.1 million shares for approximately $369.1 million, demonstrating a proactive capital management strategy aimed at enhancing shareholder value amidst market challenges.
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