Agios Pharmaceuticals Receives FDA Approval for AQVESME, Shares Surge 18%
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Dec 24 2025
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Source: Fool
- Stock Surge: Agios Pharmaceuticals' shares soared over 18% following FDA approval for AQVESME (mitapivat) to treat anemia, reflecting strong market confidence in the new therapy and its potential to drive future revenue growth.
- Market Potential: During the conference call, management noted an addressable launch population of 4,000 patients with a U.S. price of $425,000 per year, indicating significant commercialization potential in the rare disease sector.
- Sales Expectations: Combined with approvals for other indications, management believes mitapivat could achieve $1 billion in global peak-year sales across PKD and thalassemia, highlighting its broad application prospects in the global market.
- Strategic Expansion: This approval provides Agios with an opportunity to rapidly expand sales, particularly in the U.S. market, where migratory trends may bring more potential patients, further enhancing the company's competitive position.
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Analyst Views on AGIO
Wall Street analysts forecast AGIO stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for AGIO is 36.38 USD with a low forecast of 25.00 USD and a high forecast of 62.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
9 Analyst Rating
6 Buy
3 Hold
0 Sell
Moderate Buy
Current: 28.310
Low
25.00
Averages
36.38
High
62.00
Current: 28.310
Low
25.00
Averages
36.38
High
62.00
About AGIO
Agios Pharmaceuticals, Inc. is a biopharmaceutical company. The Company is focused on developing and delivering transformative therapies for patients living with rare diseases. It markets a first-in-class pyruvate kinase (PK) activator for adults with PK deficiency, the first disease-modifying therapy for debilitating hemolytic anemia. Its lead product candidate in its portfolio, PYRUKYND (mitapivat), is an activator of both wild-type and mutant pyruvate kinase, or PK, enzymes for the potential treatment of hemolytic anemias. It is also developing tebapivat, a novel PK activator, for the potential treatment of lower-risk myelodysplastic syndromes, or LR MDS, and hemolytic anemias; AG-181, its phenylalanine hydroxylase, or PAH, stabilizer for the potential treatment of phenylketonuria, or PKU; and AG-236, an siRNA in-licensed from Alnylam Pharmaceuticals, Inc., targeting the transmembrane serine protease 6, or TMPRSS6 gene for the potential treatment of polycythemia vera, or PV.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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