Acumen Pharmaceuticals Enhances Antibody Delivery for Alzheimer's at CTAD 2025
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Dec 02 2025
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Acumen Pharmaceuticals announced new research at the 18th Annual Clinical Trials on Alzheimer's Disease, CTAD, conference, taking place December 1-4, 2025, in San Diego and online. Results from a collaborative study with JCR Pharmaceuticals demonstrated improved delivery of AbetaO-targeting monoclonal antibodies to the central nervous system, including sabirnetug, ACU193, through the blood-brain barrier using the transferrin receptor pathway, which is being developed to potentially increase and broaden brain distribution and maximize the efficacy-to-safety ratio. Building on these results, Acumen and JCR Pharmaceuticals are now developing TfR-targeting antibodies for clinical testing. Additionally, results on clinical trial recruitment from the Phase 2 ALTITUDE-AD clinical trial showed that site databases and physician referrals were the most reliable recruitment methods overall.
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About ACU
Acme United Corporation is a supplier of first aid and medical products and cutting technology to the school, home, office, hardware, sporting goods and industrial markets with operations in the United States, Canada, Europe (located in Germany), and Asia (located in Hong Kong and China). The Company markets and sells under two main product categories: first aid and medical; and cutting and sharpening. The Company’s brands include First Aid Only, First Aid Central, PhysiciansCare, Spill Magic, Westcott, Clauss, DMT, Med-Nap, Safety Made and Elite. The Company sells its products primarily to mass market and e-commerce retailers, industrial distributors, wholesale, contract and retail stationery distributors, office supply superstores, sporting goods stores, and hardware chains. The Company also owns My Medic, which is a supplier of tactical, trauma and emergency response products, primarily in the direct-to-consumer channel.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
Acme United Acquires My Medic for $18.7 Million
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- Market Expansion: My Medic generated approximately $19 million in revenue in 2025, and with its strong direct-to-consumer presence and over 500,000 social media followers, Acme United plans to leverage its marketing and distribution capabilities to expand market share in the U.S. and Canada.
- Operational Integration: CEO Walter C. Johnsen stated that the combined operations will significantly enhance the value and reach of My Medic's products, particularly in the tactical and emergency response sectors, thereby strengthening the company's competitive edge.
- Strategic Investment: This acquisition not only bolsters Acme's position in the safety solutions market but also opens new opportunities for product expansion and innovation, underscoring the company's commitment to the emergency response product sector.
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Shopify Reaches $217 Billion Market Cap, Strong Market Performance
- Market Cap Growth: Shopify's market cap has reached $217 billion, significantly exceeding previous estimates of $150-190 billion, reflecting strong market confidence in its e-commerce platform.
- User Base Expansion: The company has attracted a large number of new users by providing convenient online store solutions, enhancing its market share and competitiveness in the e-commerce sector.
- Diversified Revenue Sources: Shopify not only relies on e-commerce transactions but also enhances overall profitability through diversified revenue streams such as value-added services and payment processing.
- Optimistic Future Outlook: With the continued growth of the e-commerce industry, Shopify is expected to further expand its market share, solidifying its leadership position among global e-commerce platforms.
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