AC Immune Amends Agreement with Eli Lilly, Receives CHF 10M Upfront Payment
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Apr 07 2026
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Should l Buy ACIU?
AC Immune (ACIU) announced an agreement with Eli Lilly (LLY) to amend their 2018 license and collaboration agreement to research and develop Tau aggregation inhibitor small molecules for the potential treatment of Alzheimer's disease and other neurodegenerative diseases. The amendment continues the research and collaboration to cover development of new lead Tau Morphomer candidates and potential back-up compounds. Under this amendment, AC Immune will receive a CHF 10M upfront payment and a subsequent milestone payment with Phase 1 dosing, in addition to milestones announced in a prior amendment. AC Immune is eligible for further development, regulatory and commercial milestones of over CHF1.7B, plus tiered percentage royalty payments in the low double digits, as previously disclosed.
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Analyst Views on ACIU
Wall Street analysts forecast ACIU stock price to rise
1 Analyst Rating
1 Buy
0 Hold
0 Sell
Moderate Buy
Current: 2.980
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Current: 2.980
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About ACIU
AC Immune SA is a Switzerland-based clinical-stage biopharmaceutical company. The Company focuses on precision medicine for neurodegenerative diseases. It designs, discovers and develops therapeutic, as well as diagnostic products for prevention, diagnosis and treatment of diseases caused by misfolding proteins. Its SupraAntigen and Morphomer technology platforms to create antibodies, small molecules and vaccines designed to address a broad range of neurodegenerative indications, such as Alzheimer's disease (AD). The Company's pipeline includes nine therapeutic product candidates with five in clinical trials, and three diagnostic candidates. Its lead product candidate is Crenezumab, a humanized and monoclonal anti-Abeta antibody for Alzheimer’s disease. It has collaborations with pharmaceutical companies, including Roche/Genentech, Eli Lilly, Biogen, Janssen Pharmaceuticals, Nestle Institute of Health Sciences, Life Molecular Imaging (formerly Piramal Imaging) and Essex Bio-Technology.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
AC Immune Revises Collaboration Agreement with Eli Lilly
- Collaboration Agreement Revision: AC Immune has amended its collaboration agreement with Eli Lilly, which will pay 10 million Swiss francs ($12.5 million) as an upfront payment, demonstrating confidence in AC Immune's development of treatments for Alzheimer's and other neurodegenerative diseases.
- Significant Potential Revenue: If AC Immune successfully develops a drug and meets clinical, regulatory, and commercial milestones, total payments could exceed 1.7 billion Swiss francs ($2.1 billion), significantly enhancing the company's financial position and market standing.
- Clinical Trial Progress: CEO Andrea Pfeifer indicated that the company expects to initiate Investigational New Drug (IND)-enabling studies imminently, marking a new stage in its development that could accelerate the path to market for new therapies.
- Positive Market Reaction: Following this favorable collaboration news, AC Immune's stock surged nearly 15% on Tuesday, reflecting investor optimism about the company's future prospects and increasing its visibility in the biotech sector.
See More
AC Immune Amends Collaboration Agreement with Eli Lilly
- Agreement Amendment: AC Immune has amended its 2018 collaboration agreement with Eli Lilly, continuing to cover R&D efforts for the new class of neurology therapies, Morphomer Tau, indicating ongoing partnership in neurodegenerative diseases like Alzheimer's.
- Increased Funding: The amendment allows AC Immune to receive an upfront payment of CHF 10 million and a milestone payment upon the start of Phase 1 dosing, providing crucial financial support for its R&D efforts and enhancing its financial stability.
- R&D Timeline: AC Immune plans to initiate investigational new drug (IND)-enabling studies in H1 2026, establishing a timeline that will bolster the company's competitive position in the neurodegenerative disease treatment market.
- Positive Market Reaction: Following the agreement amendment, AC Immune's stock price rose, reflecting investor optimism regarding the company's future R&D potential, which may attract more investor interest in its innovative capabilities within the biotech sector.
See More
AC Immune Amends Tau Collaboration Agreement with Lilly
- Collaboration Agreement Amendment: AC Immune has amended its 2018 collaboration agreement with Eli Lilly to develop Tau aggregation inhibitors for Alzheimer's and other neurodegenerative diseases, reflecting growing excitement for intracellular Tau targeting.
- Financial Support: Under the amended agreement, AC Immune will receive a CHF 10 million upfront payment and subsequent milestone payments upon Phase 1 dosing, along with over CHF 1.7 billion in potential development and commercial milestones, showcasing the company's strong funding capabilities in this area.
- Clinical Research Plans: Investigational New Drug (IND)-enabling studies are expected to commence in H1 2026, marking significant progress in the development of small molecule therapeutics for early intervention and long-term prevention of neurodegenerative diseases.
- Technology Platform Advantage: AC Immune's Morphomer platform has demonstrated robust preclinical data indicating its small molecules can effectively inhibit Tau protein aggregation, further solidifying the company's leadership in precision prevention of neurodegenerative diseases.
See More
AC IMMUNE SA - QUALIFIES FOR OVER CHF1.7 BILLION IN MILESTONES AND TIERED ROYALTIES
Eligibility for Overchf: The article discusses the eligibility criteria for a program or initiative referred to as "Overchf."
Financial Milestones: It highlights a significant financial milestone of 1.7 billion, indicating a substantial achievement or target within the context of the program.
See More
AC IMMUNE SA TO RECEIVE CHF 10 MILLION UPFRONT PAYMENT AND PHASE 1 MILESTONE PAYMENT UNDER AMENDMENT
Amendment Overview: The article discusses a recent amendment related to a financial agreement or contract.
Payment Details: It highlights a front payment of 10 million and mentions a milestone payment as part of the agreement.
See More
AC IMMUNE SA - REVISED AGREEMENT INCLUDES DEVELOPMENT OF NEW TAU MORPHOMER CANDIDATES
- New Development Agreement: The amended agreement focuses on the development of new TAU MORM PHOMER candidates.
- Candidate Selection: The agreement outlines the criteria and process for selecting candidates for the new development initiative.
See More
AC Immune Revises Collaboration Agreement with Eli Lilly
- Collaboration Agreement Revision: AC Immune has amended its collaboration agreement with Eli Lilly, which will pay 10 million Swiss francs ($12.5 million) as an upfront payment, demonstrating confidence in AC Immune's development of treatments for Alzheimer's and other neurodegenerative diseases.
- Significant Potential Revenue: If AC Immune successfully develops a drug and meets clinical, regulatory, and commercial milestones, total payments could exceed 1.7 billion Swiss francs ($2.1 billion), significantly enhancing the company's financial position and market standing.
- Clinical Trial Progress: CEO Andrea Pfeifer indicated that the company expects to initiate Investigational New Drug (IND)-enabling studies imminently, marking a new stage in its development that could accelerate the path to market for new therapies.
- Positive Market Reaction: Following this favorable collaboration news, AC Immune's stock surged nearly 15% on Tuesday, reflecting investor optimism about the company's future prospects and increasing its visibility in the biotech sector.
See More
AC Immune Amends Collaboration Agreement with Eli Lilly
- Agreement Amendment: AC Immune has amended its 2018 collaboration agreement with Eli Lilly, continuing to cover R&D efforts for the new class of neurology therapies, Morphomer Tau, indicating ongoing partnership in neurodegenerative diseases like Alzheimer's.
- Increased Funding: The amendment allows AC Immune to receive an upfront payment of CHF 10 million and a milestone payment upon the start of Phase 1 dosing, providing crucial financial support for its R&D efforts and enhancing its financial stability.
- R&D Timeline: AC Immune plans to initiate investigational new drug (IND)-enabling studies in H1 2026, establishing a timeline that will bolster the company's competitive position in the neurodegenerative disease treatment market.
- Positive Market Reaction: Following the agreement amendment, AC Immune's stock price rose, reflecting investor optimism regarding the company's future R&D potential, which may attract more investor interest in its innovative capabilities within the biotech sector.
See More
AC Immune Amends Tau Collaboration Agreement with Lilly
- Collaboration Agreement Amendment: AC Immune has amended its 2018 collaboration agreement with Eli Lilly to develop Tau aggregation inhibitors for Alzheimer's and other neurodegenerative diseases, reflecting growing excitement for intracellular Tau targeting.
- Financial Support: Under the amended agreement, AC Immune will receive a CHF 10 million upfront payment and subsequent milestone payments upon Phase 1 dosing, along with over CHF 1.7 billion in potential development and commercial milestones, showcasing the company's strong funding capabilities in this area.
- Clinical Research Plans: Investigational New Drug (IND)-enabling studies are expected to commence in H1 2026, marking significant progress in the development of small molecule therapeutics for early intervention and long-term prevention of neurodegenerative diseases.
- Technology Platform Advantage: AC Immune's Morphomer platform has demonstrated robust preclinical data indicating its small molecules can effectively inhibit Tau protein aggregation, further solidifying the company's leadership in precision prevention of neurodegenerative diseases.
See More
AC IMMUNE SA - QUALIFIES FOR OVER CHF1.7 BILLION IN MILESTONES AND TIERED ROYALTIES
Eligibility for Overchf: The article discusses the eligibility criteria for a program or initiative referred to as "Overchf."
Financial Milestones: It highlights a significant financial milestone of 1.7 billion, indicating a substantial achievement or target within the context of the program.
See More
AC IMMUNE SA TO RECEIVE CHF 10 MILLION UPFRONT PAYMENT AND PHASE 1 MILESTONE PAYMENT UNDER AMENDMENT
Amendment Overview: The article discusses a recent amendment related to a financial agreement or contract.
Payment Details: It highlights a front payment of 10 million and mentions a milestone payment as part of the agreement.
See More
AC IMMUNE SA - REVISED AGREEMENT INCLUDES DEVELOPMENT OF NEW TAU MORPHOMER CANDIDATES
- New Development Agreement: The amended agreement focuses on the development of new TAU MORM PHOMER candidates.
- Candidate Selection: The agreement outlines the criteria and process for selecting candidates for the new development initiative.
See More
