AstraZeneca to Delist from Nasdaq, Transition to NYSE
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Jan 20 2026
0mins
Should l Buy AZN?
Source: Benzinga
AstraZeneca's stock fell 5.01% as it crossed below the 20-day SMA amid broader market declines, with the Nasdaq-100 down 1.53% and the S&P 500 down 1.33%.
The company announced its voluntary withdrawal from Nasdaq, with trading for its American Depositary Shares ceasing on January 30, 2026. This strategic shift aims to enhance its global market presence by directly listing on the NYSE starting February 2, 2026, which is expected to provide a unified listing structure for global investors and improve market visibility.
This transition reflects AstraZeneca's strategy to align its trading platforms and enhance its appeal to investors, particularly in the U.S. market, while also indicating a reassessment of its future strategy in light of market dynamics.
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Analyst Views on AZN
Wall Street analysts forecast AZN stock price to rise
14 Analyst Rating
13 Buy
0 Hold
1 Sell
Strong Buy
Current: 194.950
Low
157.61
Averages
213.64
High
252.18
Current: 194.950
Low
157.61
Averages
213.64
High
252.18
About AZN
AstraZeneca PLC is a United Kingdom-based science-led biopharmaceutical company. The Company focuses on the discovery, development, and commercialization of prescription medicines. The Company operates across therapy areas, including Oncology; Cardiovascular, Renal and Metabolism (CVRM); Respiratory and Immunology (R&I); Vaccines and Immune Therapies (V&I), and Rare Disease. In the Oncology area, its key products include Tagrisso, Imfinzi, Calquence, Lynparza, and Enhertu. The key products of CVRM area include Farxiga/Forxiga, Brilinta/Brilique, Crestor, and Lokelma. In the R&I area, the key products are Symbicort, Fasenra, Breztri/Trixeo, and Tezspire. In the V&I Therapies area, the products are Beyfortus and FluMist. The products in the Rare Disease area are Ultomiris, Soliris, Strensiq, and Koselugo. It has about 191 projects in its development pipeline, including 19 new molecular entities (NMEs) in the late-stage pipeline. The Company distributes its products in over 125 countries.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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- Health Campaign Collaboration: Joshua Jackson teams up with AstraZeneca and Gritty, the Philadelphia Flyers mascot, to launch the national 'Get Body Checked Against Cancer' campaign, aimed at encouraging fans to proactively discuss cancer screenings with their doctors, especially as 65% of Americans are behind on recommended screenings.
- Cultural Relevance: Jackson's status as a public figure resonates with a younger generation, emphasizing the importance of timely conversations about cancer risk as they enter a life stage where such discussions become increasingly critical, thereby fostering broader health dialogues.
- Funding Commitment: AstraZeneca has donated $1.1 million to the Hockey Fights Cancer initiative through the V Foundation, demonstrating its strong commitment to advancing cancer screening and research, further solidifying its role as the first-ever official national partner of Hockey Fights Cancer.
- Call to Action: Mohit Manrao, Senior VP of US Oncology at AstraZeneca, stresses that timely action can save lives, urging fans to take charge of their health, particularly as cancer rates rise among those under 50, and encouraging everyone not to wait to get body checked.
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- New Drug Approval: AstraZeneca's Koselugo has been approved in Canada for treating adult patients with symptomatic, inoperable neurofibromatosis type 1, marking a significant expansion in the company's rare disease portfolio.
- Clinical Trial Support: The approval is based on positive results from the KOMET Phase III trial, demonstrating Koselugo's efficacy in alleviating patient symptoms, thereby laying a foundation for AstraZeneca's global marketing efforts.
- International Approval Progress: Koselugo has recently received approvals in multiple countries, including the US, EU, and Japan, indicating increasing recognition in international markets and enhancing AstraZeneca's competitive position.
- Market Reaction: In pre-market trading on the NYSE, AstraZeneca shares fell 2.78% to $188.92, reflecting a cautious market response to the drug's approval, which may impact the company's short-term stock performance.
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- Priority Review Approval: ENHERTU's supplemental Biologics License Application has been accepted for Priority Review in the US, with a regulatory decision expected in Q3 2026, potentially establishing it as a new standard of care and significantly improving patient outcomes.
- Breakthrough Therapy Designation: ENHERTU has received Breakthrough Therapy Designation from the FDA for this indication, indicating its potential to address serious conditions and possibly accelerating its path to market to meet significant unmet medical needs.
- International Collaborative Review: The application is also under review through Project Orbis, which allows for concurrent submission and review of oncology medicines among international partners, further enhancing ENHERTU's competitive position in the global market.
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- Project Background: The application is being reviewed under Project Orbis, aimed at accelerating the approval process for new drugs globally, indicating regulatory agencies' recognition of ENHERTU's significance in the treatment landscape and its potential market impact.
- International Review Progress: Regulatory submissions for ENHERTU are also under review in the EU and Japan based on the DESTINY-Breast05 study results, further enhancing its competitiveness and recognition in the global market.
- Market Performance: Daiichi Sankyo shares are currently trading at 2,849 yen, down 0.63%, reflecting market caution regarding the drug's approval progress and potentially impacting investor confidence in the company's future growth.
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ENHERTU Shows 53% Reduction in Breast Cancer Recurrence Risk in Phase 3 Trial
- Clinical Trial Results: The DESTINY-Breast05 trial demonstrated that ENHERTU reduced the risk of invasive disease recurrence or death by 53% compared to T-DM1, providing new treatment hope for early breast cancer patients.
- Priority Review Approval: The supplemental Biologics License Application for ENHERTU by Daiichi Sankyo and AstraZeneca has been accepted for Priority Review in the U.S., and if approved, it could establish a new standard of care for HER2 positive early breast cancer, significantly enhancing market competitiveness.
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Xencor Lowers Outlook After Royalty Dispute
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- Royalty Revenue Adjustment: Xencor stated that Alexion has informed the company it will no longer owe additional royalties related to Ultomiris net sales in the U.S., although payments for sales outside the U.S. will continue, potentially leading to future revenue uncertainty.
- Cash Flow Forecast Downgrade: The company updated its year-end cash guidance, projecting cash, cash equivalents, and marketable debt securities to reach $380 million to $400 million by year-end, down from the previous estimate of $400 million to $430 million, reflecting a cautious outlook on future operations.
- Shortened Operating Runway: Xencor's revised operating runway forecast has also been shortened, now expected to last until mid-2028, down from prior guidance, indicating increased financial pressure on the company amid the royalty dispute.
See More
Joshua Jackson Partners with AstraZeneca to Promote Cancer Screening
- Health Campaign Collaboration: Joshua Jackson teams up with AstraZeneca and Gritty, the Philadelphia Flyers mascot, to launch the national 'Get Body Checked Against Cancer' campaign, aimed at encouraging fans to proactively discuss cancer screenings with their doctors, especially as 65% of Americans are behind on recommended screenings.
- Cultural Relevance: Jackson's status as a public figure resonates with a younger generation, emphasizing the importance of timely conversations about cancer risk as they enter a life stage where such discussions become increasingly critical, thereby fostering broader health dialogues.
- Funding Commitment: AstraZeneca has donated $1.1 million to the Hockey Fights Cancer initiative through the V Foundation, demonstrating its strong commitment to advancing cancer screening and research, further solidifying its role as the first-ever official national partner of Hockey Fights Cancer.
- Call to Action: Mohit Manrao, Senior VP of US Oncology at AstraZeneca, stresses that timely action can save lives, urging fans to take charge of their health, particularly as cancer rates rise among those under 50, and encouraging everyone not to wait to get body checked.
See More
AstraZeneca's Koselugo Approved in Canada
- New Drug Approval: AstraZeneca's Koselugo has been approved in Canada for treating adult patients with symptomatic, inoperable neurofibromatosis type 1, marking a significant expansion in the company's rare disease portfolio.
- Clinical Trial Support: The approval is based on positive results from the KOMET Phase III trial, demonstrating Koselugo's efficacy in alleviating patient symptoms, thereby laying a foundation for AstraZeneca's global marketing efforts.
- International Approval Progress: Koselugo has recently received approvals in multiple countries, including the US, EU, and Japan, indicating increasing recognition in international markets and enhancing AstraZeneca's competitive position.
- Market Reaction: In pre-market trading on the NYSE, AstraZeneca shares fell 2.78% to $188.92, reflecting a cautious market response to the drug's approval, which may impact the company's short-term stock performance.
See More
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- Clinical Trial Results: The DESTINY-Breast05 Phase III trial demonstrated that ENHERTU reduces the risk of invasive disease recurrence or death by 53% compared to T-DM1, providing new hope for patients with HER2-positive early breast cancer.
- Priority Review Approval: ENHERTU's supplemental Biologics License Application has been accepted for Priority Review in the US, with a regulatory decision expected in Q3 2026, potentially establishing it as a new standard of care and significantly improving patient outcomes.
- Breakthrough Therapy Designation: ENHERTU has received Breakthrough Therapy Designation from the FDA for this indication, indicating its potential to address serious conditions and possibly accelerating its path to market to meet significant unmet medical needs.
- International Collaborative Review: The application is also under review through Project Orbis, which allows for concurrent submission and review of oncology medicines among international partners, further enhancing ENHERTU's competitive position in the global market.
See More
Daiichi Sankyo and AstraZeneca's ENHERTU Application Receives Priority Review
- Application Approval: Daiichi Sankyo and AstraZeneca's supplemental Biologics License Application for ENHERTU has been accepted for Priority Review in the U.S., targeting adult patients with HER2 positive breast cancer who have residual invasive disease after neoadjuvant HER2 targeted treatment, highlighting the collaboration potential in cancer drug development.
- Project Background: The application is being reviewed under Project Orbis, aimed at accelerating the approval process for new drugs globally, indicating regulatory agencies' recognition of ENHERTU's significance in the treatment landscape and its potential market impact.
- International Review Progress: Regulatory submissions for ENHERTU are also under review in the EU and Japan based on the DESTINY-Breast05 study results, further enhancing its competitiveness and recognition in the global market.
- Market Performance: Daiichi Sankyo shares are currently trading at 2,849 yen, down 0.63%, reflecting market caution regarding the drug's approval progress and potentially impacting investor confidence in the company's future growth.
See More
ENHERTU Shows 53% Reduction in Breast Cancer Recurrence Risk in Phase 3 Trial
- Clinical Trial Results: The DESTINY-Breast05 trial demonstrated that ENHERTU reduced the risk of invasive disease recurrence or death by 53% compared to T-DM1, providing new treatment hope for early breast cancer patients.
- Priority Review Approval: The supplemental Biologics License Application for ENHERTU by Daiichi Sankyo and AstraZeneca has been accepted for Priority Review in the U.S., and if approved, it could establish a new standard of care for HER2 positive early breast cancer, significantly enhancing market competitiveness.
- FDA Target Date: The FDA has set a PDUFA date of July 7, 2026, and if ENHERTU is approved, it will offer patients a more effective treatment option, potentially transforming the landscape of breast cancer treatment.
- Safety Analysis: In the DESTINY-Breast05 trial, the safety profile of ENHERTU was consistent with its known characteristics, with grade 3 or higher adverse event rates comparable to T-DM1, indicating good tolerability.
See More
Xencor Lowers Outlook After Royalty Dispute
- Stock Price Decline: Xencor (XNCR) shares fell approximately 8% on Thursday, primarily due to the company's lowered outlook following a royalty dispute with AstraZeneca's subsidiary Alexion Pharmaceuticals, indicating market concerns about future earnings.
- Royalty Revenue Adjustment: Xencor stated that Alexion has informed the company it will no longer owe additional royalties related to Ultomiris net sales in the U.S., although payments for sales outside the U.S. will continue, potentially leading to future revenue uncertainty.
- Cash Flow Forecast Downgrade: The company updated its year-end cash guidance, projecting cash, cash equivalents, and marketable debt securities to reach $380 million to $400 million by year-end, down from the previous estimate of $400 million to $430 million, reflecting a cautious outlook on future operations.
- Shortened Operating Runway: Xencor's revised operating runway forecast has also been shortened, now expected to last until mid-2028, down from prior guidance, indicating increased financial pressure on the company amid the royalty dispute.
See More
